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公开(公告)号：US20080242667A1
公开(公告)日：2008-10-02
申请号：US12064820
申请日：2006-08-23
IPC分类号： A61K31/5377 , C07D413/02 , A61K31/496 , A61P35/00 , C07D403/02
CPC分类号： C07D403/04
摘要： The present invention provides a compound represented by Formula (I): or a salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein.The present invention also relates to a composition comprising the compound of formula (I) and diluents, carriers, or excipients. Furthermore, the present invention relates to a method of treating a disease of cell proliferation comprising administering to a patient in need thereof a pharmaceutically effective amount of the compound of formula (I) or a salt thereof, or a solvate thereof, or a combination thereof.
摘要翻译： 本发明提供由式（I）表示的化合物或其盐，或其溶剂合物或其组合，其中取代基如本文所定义。 本发明还涉及包含式（I）化合物和稀释剂，载体或赋形剂的组合物。 此外，本发明涉及治疗细胞增殖疾病的方法，包括向有需要的患者施用药学有效量的式（I）化合物或其盐或其溶剂合物或其组合 。
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公开(公告)号：US20100234386A1
公开(公告)日：2010-09-16
申请号：US12599544
申请日：2008-05-08
申请人： Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
发明人： Amita Chaudhari , Dashyant Dhanak , Carla Ann Donatelli , Thomas H. Faitg , Yanhong Feng , Steven David Knight , Cynthia A. Parrish , Jeffrey M. Ralph , Martha A. Sarpong , Domingos J. Silva
IPC分类号： A61K31/498 , C07D401/02 , A61P29/00 , A61P9/00 , A61P25/00 , A61P11/06 , A61P13/12 , A61P35/00 , A61P15/00
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
摘要： Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
摘要翻译： 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法：自身免疫性疾病，炎性疾病，心血管疾病，神经变性疾病，变态反应，哮喘，胰腺炎，多器官功能衰竭，肾脏疾病，血小板聚集，癌症，精子活力，移植排斥反应， 通过施用喹喔啉衍生物的移植排斥和肺部损伤。
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公开(公告)号：US20100016318A1
公开(公告)日：2010-01-21
申请号：US12524009
申请日：2008-01-25
申请人： Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H. Faitg , Timothy Francis Gallagher , Neil W. Johnson , Jiri Kasparec , Jeffrey M. Ralph , Domingos J. Silva
发明人： Jeffrey Michael Axten , Deborah L. Bryan , David Harold Drewry , Thomas H. Faitg , Timothy Francis Gallagher , Neil W. Johnson , Jiri Kasparec , Jeffrey M. Ralph , Domingos J. Silva
IPC分类号： A61K31/5355 , A61K31/541 , A61K31/505 , A61K31/506 , C07D279/12 , C07D403/02 , C07D239/24 , C07D413/02
CPC分类号： C07D403/12 , C07D241/20 , C07D413/12
摘要： The present invention relates to a compound represented by the following formula: or a pharmaceutically acceptable salt thereof; wherein R1, R1′ R2, R3, R4, R5, r and s are as defined herein. Compounds of the present invention are useful in the treatment of diseases associated with Aurora kinase activity such as cancer.
摘要翻译： 本发明涉及由下式表示的化合物或其药学上可接受的盐; 其中R1，R1'R2，R3，R4，R5，r和s如本文所定义。 本发明的化合物可用于治疗与极光激酶活性相关的疾病如癌症。
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公开(公告)号：US08415345B2
公开(公告)日：2013-04-09
申请号：US12991004
申请日：2009-05-04
申请人： George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
发明人： George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
IPC分类号： C07D403/14 , A61K31/505
CPC分类号： C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译： 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。
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公开(公告)号：US20090298815A1
公开(公告)日：2009-12-03
申请号：US12434963
申请日：2009-05-04
申请人： Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
发明人： Jerry Leroy Adams , Scott Howard Dickerson , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David Edward Uehling , Alex Gregory Waterson , Brian Wilson
IPC分类号： A61K31/506 , C07D417/04 , C07D417/14 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译： 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。
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公开(公告)号：US20130144055A1
公开(公告)日：2013-06-06
申请号：US13755466
申请日：2013-01-31
申请人： George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
发明人： George Adjabeng , Jerry Leroy Adams , Scott Howard Dickerson , Keith Hornberger , Neil W. Johnson , Kevin Kuntz , Kimberly Petrov , Jeffrey M. Ralph , Tara Renae Rheault , Gregory Schaaf , John Stellwagen , Xinrong Tian , David E. Uehling , Alex G. Waterson , Brian Wilson
IPC分类号： C07D417/14 , C07D417/04 , C07D413/04 , C07D413/14 , C07D403/14
CPC分类号： C07D417/14 , A61K31/427 , C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.
摘要翻译： 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。
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公开(公告)号：US08895543B2
公开(公告)日：2014-11-25
申请号：US11697415
申请日：2007-04-06
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： A61K31/33 , A61K31/395 , C07D519/04
CPC分类号： C07D519/04
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
摘要翻译： 本发明涉及长春花生物碱的衍生物。 还公开了含有这些化合物的药物组合物以及各种条件的制备和处理方法。
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公开(公告)号：US20090088568A1
公开(公告)日：2009-04-02
申请号：US12331691
申请日：2008-12-10
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： C07D491/14
CPC分类号： C07D519/00 , C07D519/04
摘要： The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
摘要翻译： 本发明涉及新的长春瑞滨衍生物。 还公开了含有这些化合物的药物组合物以及制备方法和用于治疗各种病症的用途。
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公开(公告)号：US07745619B2
公开(公告)日：2010-06-29
申请号：US11933259
申请日：2007-10-31
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： C07D245/00
CPC分类号： C07D519/04
摘要： The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.
摘要翻译： 本发明涉及长春花生物碱的衍生物。 还公开了含有这些化合物的药物组合物以及各种条件的制备和处理方法。
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公开(公告)号：US07235564B2
公开(公告)日：2007-06-26
申请号：US11003583
申请日：2004-12-03
申请人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
发明人： Ian L. Scott , Jeffrey M. Ralph , Matthew E. Voss
IPC分类号： A61P35/00 , A61K31/4745 , C07D487/22
CPC分类号： C07D519/00 , C07D519/04
摘要： The present invention relates to novel vinorelbine derivatives. Pharmaceutical compositions containing these compounds as well as processes of preparation and processes of use for treatment of various conditions are also disclosed.
摘要翻译： 本发明涉及新的长春瑞滨衍生物。 还公开了含有这些化合物的药物组合物以及制备方法和用于治疗各种病症的用途。
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