-
公开(公告)号:US08343980B2
公开(公告)日:2013-01-01
申请号:US12688163
申请日:2010-01-15
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61K31/496 , A61K31/4523 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D401/04 , C07D403/04
CPC分类号: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US20110021495A1
公开(公告)日:2011-01-27
申请号:US12688163
申请日:2010-01-15
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T.D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T.D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/397 , C07D403/04 , A61K31/517 , C07D401/14 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P19/00 , C12N5/07
CPC分类号: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08153642B2
公开(公告)日:2012-04-10
申请号:US12714871
申请日:2010-03-01
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D239/94 , C07D403/12
CPC分类号: C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
4.
公开(公告)号:US08163720B2
公开(公告)日:2012-04-24
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A01N51/00 , A61N31/655
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
-
5.
公开(公告)号:US08236833B2
公开(公告)日:2012-08-07
申请号:US12697671
申请日:2010-02-01
申请人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
发明人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
IPC分类号: A61K31/425
CPC分类号: C07D417/12 , C07D275/03 , C07D277/44
摘要: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
-
公开(公告)号:US20120178713A1
公开(公告)日:2012-07-12
申请号:US13419936
申请日:2012-03-14
申请人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/496 , C07D403/12 , A61K31/506 , C07D417/14 , A61K31/501 , A61K31/454 , C07D471/04 , A61K31/437 , A61K31/427 , C07F7/02 , A61K31/695 , C07D413/14 , A61K31/5377 , A61P35/00 , A61P19/02 , A61P25/06 , A61P25/08 , A61P25/28 , A61P25/22 , A61P25/24 , A61P1/00 , A61P13/02 , C07D417/12
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
-
公开(公告)号:US20110082117A1
公开(公告)日:2011-04-07
申请号:US12844047
申请日:2010-07-27
申请人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
发明人: Esther Martinborough , Lev T.D. Fanning , Urvi Sheth , Dean Wilson , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Tara Leanne Hampton , Tara Whitney , Aarti Sameer Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Anderson
IPC分类号: A61K31/635 , A61K31/454 , A61K31/4178 , A61P29/00 , A61P25/00 , A61P13/00 , A61P17/00
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08362032B2
公开(公告)日:2013-01-29
申请号:US12830743
申请日:2010-07-06
申请人: Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
发明人: Aarti Sameer Kawatkar , Tara Whitney , Timothy D. Neubert , Nicole Hilgraf , Andreas P. Termin , Esther Martinborough
IPC分类号: C07D417/12 , A61K31/47
CPC分类号: C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要: Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
-
公开(公告)号:US08314125B2
公开(公告)日:2012-11-20
申请号:US12761502
申请日:2010-04-16
申请人: Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
发明人: Andreas P. Termin , Nicole Hilgraf , Tara Leanne Hampton , Gabriel Martinez-Botella , Esther Martinborough
IPC分类号: A61K31/04
CPC分类号: C07D417/12 , C07D401/12
摘要: The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
-
公开(公告)号:US08129546B2
公开(公告)日:2012-03-06
申请号:US12879237
申请日:2010-09-10
申请人: Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
发明人: Esther Martinborough , Andreas P. Termin , Timothy D. Neubert , Nicole Hilgraf , Corey Anderson
IPC分类号: C07D209/04 , A61K31/405
CPC分类号: C07D401/08 , C07D207/10 , C07D207/12 , C07D211/54 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/08
摘要: Sulfonamide derivatives act as ion channel antagonists. The compositions are useful for treating or relieving pain-related conditions.
摘要翻译: 磺酰胺衍生物作为离子通道拮抗剂。 该组合物可用于治疗或缓解疼痛相关病症。
-
-
-
-
-
-
-
-
-