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公开(公告)号:US08343980B2
公开(公告)日:2013-01-01
申请号:US12688163
申请日:2010-01-15
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T. D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61K31/496 , A61K31/4523 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D401/04 , C07D403/04
CPC分类号: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20110021495A1
公开(公告)日:2011-01-27
申请号:US12688163
申请日:2010-01-15
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T.D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter D. J. Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev T.D. Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/397 , C07D403/04 , A61K31/517 , C07D401/14 , C07D413/14 , A61K31/5377 , A61P29/00 , A61P25/00 , A61P19/00 , C12N5/07
CPC分类号: C07D239/94 , C07D239/91 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08153642B2
公开(公告)日:2012-04-10
申请号:US12714871
申请日:2010-03-01
申请人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
发明人: Jesus Gonzalez, III , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Hilgraf
IPC分类号: A61K31/517 , A61P19/02 , A61P25/06 , A61P25/08 , A61P29/02 , A61P35/00 , C07D239/94 , C07D403/12
CPC分类号: C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20060217377A1
公开(公告)日:2006-09-28
申请号:US10935008
申请日:2004-09-02
申请人: Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
发明人: Jesus Gonzalez , Dean Wilson , Andreas Termin , Peter Grootenhuis , Yulian Zhang , Benjamin Petzoldt , Lev Fanning , Timothy Neubert , Roger Tung , Esther Martinborough , Nicole Zimmerman
IPC分类号: A61K31/5377 , A61K31/517 , C07D413/02 , C07D43/02
CPC分类号: C07D239/91 , C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道和钙通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07799822B2
公开(公告)日:2010-09-21
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A01N43/36
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译: 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病(包括例如治疗疼痛)的方法。
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公开(公告)号:US20050187217A1
公开(公告)日:2005-08-25
申请号:US10912912
申请日:2004-08-05
申请人: Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
发明人: Dean Wilson , Andreas Termin , Timothy Neubert , Jian Wang , Yulian Zhang , Jesus Gonzalez , Esther Martinborough , Nicole Zimmerman
IPC分类号: A61K31/517 , A61K31/5377 , A61P25/00 , A61P29/00 , C07D239/70 , C07D239/91 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/12 , C07D413/02 , C07D471/04 , C07D495/04 , C07D43/02
CPC分类号: C07D401/04 , C07D239/70 , C07D239/91 , C07D239/94 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D471/04 , C07D495/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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7.
公开(公告)号:US08236833B2
公开(公告)日:2012-08-07
申请号:US12697671
申请日:2010-02-01
申请人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
发明人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
IPC分类号: A61K31/425
CPC分类号: C07D417/12 , C07D275/03 , C07D277/44
摘要: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号:US20080027067A1
公开(公告)日:2008-01-31
申请号:US11643622
申请日:2006-12-21
申请人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人: Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号: A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号: C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要: The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20050049247A1
公开(公告)日:2005-03-03
申请号:US10884865
申请日:2004-07-02
申请人: Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
发明人: Dean Wilson , Esther Martinborough , Timothy Neubert , Andreas Termin , Jesus Gonzalez , Nicole Zimmerman
IPC分类号: C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04 , A61K31/541 , A61K31/506 , A61K31/5377 , C07D413/14 , C07D417/14 , C07D43/14
CPC分类号: C07D239/42 , C07D239/48 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D413/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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10.
公开(公告)号:US20080113990A1
公开(公告)日:2008-05-15
申请号:US11546669
申请日:2006-10-12
申请人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
发明人: Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
IPC分类号: A61K31/53 , A61K31/501 , A61K31/433 , A61K31/427 , A61K31/4245
CPC分类号: C07D417/12 , C07D275/03 , C07D277/44
摘要: Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译: 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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