专利检索 ap:("Ji-Ye WEI" OR "Richard L. ORNBERG" OR "Gustav GRAFF") AND inv:"Richard L. ORNBERG" 第 1 页

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发明申请
USE OF THY1-FP TRANSGENIC MOUSE FOR THE IDENTIFICATION OF OPHTHALMIC AGENTS 审中-公开
标题翻译：使用THI1-FP转基因小鼠鉴定眼科药物

公开(公告)号：US20080188573A1

公开(公告)日：2008-08-07

申请号：US12025515

申请日：2008-02-04

申请人： Ji-Ye WEI , Richard L. ORNBERG , Gustav GRAFF

发明人： Ji-Ye WEI , Richard L. ORNBERG , Gustav GRAFF

IPC分类号： A61K45/00 , G01N33/00

CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/052 , A01K2227/105 , A01K2267/03

摘要： The present invention relates to the use of thy1-FP (fluorescent protein) non-human transgenic animals such as mice to screen for ophthalmic agents that can be used to treat corneal dry eye syndrome and/or retinal neuropathies associated with glaucoma and/or age-related macular degeneration. Such ophthalmic agents may be selected by assessing their ability to provide protection in ocular tissue.

摘要翻译： 本发明涉及使用thy1-FP（荧光蛋白）非人转基因动物如小鼠来筛选可用于治疗与青光眼和/或年龄相关的角膜干眼综合征和/或视网膜神经病变的眼科剂相关性黄斑变性。可以通过评估它们在眼组织中提供保护的能力来选择这样的眼科剂。