公开(公告)号：US07547523B2

公开(公告)日：2009-06-16

申请号：US11620337

申请日：2007-01-05

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick James Monsma, Jr. ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： G01N33/567 ,  C07K14/705

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

公开(公告)号：US06613533B2

公开(公告)日：2003-09-02

申请号：US09812216

申请日：2001-03-19

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： G01N33566

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

公开(公告)号：US06204017B1

公开(公告)日：2001-03-20

申请号：US09414010

申请日：1999-10-07

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： C12N1512

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

公开(公告)号：US07166705B2

公开(公告)日：2007-01-23

申请号：US10616088

申请日：2003-07-08

申请人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

发明人： Jiang X. Behan ,  Joseph A. Hedrick ,  Thomas M. Laz ,  Frederick J. Monsma ,  Kelley L. Morse ,  Shelby P. Umland ,  Suke Wang

IPC分类号： C07K16/28

CPC分类号： G01N33/566 ,  C07K14/723 ,  G01N2333/4719

摘要： The present invention provides an isolated mammalian histamine receptor, isolated or recombinant nucleic acids and recombinant vectors encoding the same, host cells comprising the nucleic acids and vectors, and methods of making the receptor using the host cells. This invention further provides antibodies and antigen binding fragments thereof which specifically bind to the receptor and are useful for treating medical conditions caused or mediated by histamine. Also provided are screening methods for identifying specific agonists and antagonists of the mammalian histamine receptor.

摘要翻译： 本发明提供分离的哺乳动物组胺受体，分离或重组的核酸和编码其的重组载体，包含核酸和载体的宿主细胞，以及使用宿主细胞制备受体的方法。 本发明进一步提供了与受体特异性结合并可用于治疗由组胺引起或介导的医学病症的抗体及其抗原结合片段。 还提供了用于鉴定哺乳动物组胺受体的特异性激动剂和拮抗剂的筛选方法。

公开(公告)号：US07067273B2

公开(公告)日：2006-06-27

申请号：US10741205

申请日：2003-12-19

申请人： Rumin Zhang ,  Jun Zou ,  Feng X. Zhu ,  James P. Durkin ,  William T. Windsor ,  Shelby P. Umland

发明人： Rumin Zhang ,  Jun Zou ,  Feng X. Zhu ,  James P. Durkin ,  William T. Windsor ,  Shelby P. Umland

IPC分类号： C07K7/06 ,  C07K7/08 ,  C12Q1/37

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C12N9/6489 ,  C12Q1/37 ,  G01N2500/00

摘要： The present invention discloses peptide substrates of a proteolytic ADAM33 polypeptide. The present invention also discloses methods of identifying additional substrates of a proteolytic ADAM33 polypeptide. Furthermore, the present invention discloses methods of identifying compounds that inhibit the proteolytic activity of a proteolytic ADAM33 polypeptide.