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公开(公告)号:US08722692B2
公开(公告)日:2014-05-13
申请号:US13386645
申请日:2010-07-30
申请人: Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
发明人: Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
IPC分类号: A01N43/90 , A61K31/519 , C07D471/00 , C07D487/00
CPC分类号: C07D471/04
摘要: Provided herein are a novel class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
摘要翻译: 本文提供了一类新的式(I)化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。
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公开(公告)号:US20120184526A1
公开(公告)日:2012-07-19
申请号:US13386645
申请日:2010-07-30
申请人: Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
发明人: Jianwei Che , Qiang Ding , Xiaohui He , Hong Liu , Yahua Liu , Pierre-Yves Michellys , Barun Okram , Xu Wu , Kunyong Yang , Xuefeng Zhu
IPC分类号: A61K31/5377 , A61K31/519 , A61P35/00 , A61P37/08 , A61P29/00 , A61P19/02 , C07D471/04 , A61K31/496
CPC分类号: C07D471/04
摘要: Provided herein are a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
摘要翻译: 本文提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。
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公开(公告)号:US20110053897A1
公开(公告)日:2011-03-03
申请号:US12843771
申请日:2010-07-26
申请人: Jianwei CHE , Bei Chen , Qiang Ding , Xueshi Hao , Xiaohui He , Songchun Jiang , Qihui Jin , Yunho Jin , Hong Liu , Yahua Liu , Barun Okram , Tetsuo Uno , Xu Wu , Kunyong Yang , Xuefeng Zhu
发明人: Jianwei CHE , Bei Chen , Qiang Ding , Xueshi Hao , Xiaohui He , Songchun Jiang , Qihui Jin , Yunho Jin , Hong Liu , Yahua Liu , Barun Okram , Tetsuo Uno , Xu Wu , Kunyong Yang , Xuefeng Zhu
IPC分类号: A61K31/635 , C07D471/04 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/444 , A61P11/06 , A61P19/02 , A61P35/00 , A61P7/06 , A61P25/00
CPC分类号: C07D471/04 , A61K31/4375
摘要: Provided herein area novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated Syk kinase activity.
摘要翻译: 本文提供了区域新颖的化合物类,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的Syk激酶活性相关的疾病或病症的方法。
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公开(公告)号:US08546370B2
公开(公告)日:2013-10-01
申请号:US12865339
申请日:2009-01-27
申请人: Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
发明人: Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
IPC分类号: A61K31/33
CPC分类号: C07D471/04
摘要: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS, or combinations thereof.
摘要翻译: 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调激酶活性相关的疾病或病症的方法,特别是Syk,ZAP70,KDR,FMS,FLT3,c-Kit,RET,TrkA,TrkB,TrkC-GR -1R,Alk,c-FMS或其组合。
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公开(公告)号:US20110003798A1
公开(公告)日:2011-01-06
申请号:US12865339
申请日:2009-01-27
申请人: Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
发明人: Barun Okram , Tetsuo Uno , Qiang Ding , Yahua Liu , Yunho Jin , Qihui Jin , Xu Wu , Jianwei Che , S. Frank Yan , Xueshi Hao
IPC分类号: A61K31/5415 , C07D471/04 , C07D498/04 , A61K31/4375 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/541 , A61K31/497 , A61K31/538 , A61K31/5383 , A61K31/501 , A61P11/06 , A61P11/08 , A61P11/00 , A61P17/00 , A61P17/06 , A61P11/02 , A61P29/00 , A61P25/00 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号: C07D471/04
摘要: The invention provides a novel class of 2,7-naphthyridin derivatives; pharmaceutical compositions comprising such compounds and methods of using such compounds to treat o prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT*, c-Kit, RET, TrkA, TrkB, TrkC-GR-1R, Alk, c-FMS or combinations thereof.
摘要翻译: 本发明提供了一类新的2,7-萘啶衍生物; 包含这些化合物的药物组合物和使用这些化合物治疗的方法o预防与异常或失调的激酶活性相关的疾病或病症,特别是Syk,ZAP70,KDR,FMS,FLT *,c-Kit,RET,TrkA,TrkB,TrkC- GR-1R,Alk,c-FMS或其组合。
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公开(公告)号:US20080287432A1
公开(公告)日:2008-11-20
申请号:US12063550
申请日:2006-08-15
申请人: Barun Okram , Pingda Ren , Nathanael S. Gray
发明人: Barun Okram , Pingda Ren , Nathanael S. Gray
IPC分类号: A61K31/5377 , C07D495/14 , A61K31/4365 , A61K31/496 , C07D413/12
CPC分类号: C07D471/14 , C07D495/14
摘要: The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-AbI, Aurora-A, SGK, Tie-2, Trk-B, FGFR3, c-kit, b-RAF, c-RAF, DYRK2, Fms, Fyn and PDGFRalpha and PDGFR&bgr; kinases.
摘要翻译: 本发明提供了一类新颖的式I化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及AbI异常活化的疾病或病症, Bcr-AbI,Aurora-A,SGK,Tie-2,Trk-B,FGFR3,c-kit,b-RAF,c-RAF,DYRK2,Fms,Fyn和PDGFRα和PDGFRβ激酶。
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公开(公告)号:US20190084990A1
公开(公告)日:2019-03-21
申请号:US16170921
申请日:2018-10-25
申请人: Nathanael S. Gray , Jianming Zhang , Barun Okram , Xianming Deng , Jae Won Chang , Amy Wojciechowski
发明人: Nathanael S. Gray , Jianming Zhang , Barun Okram , Xianming Deng , Jae Won Chang , Amy Wojciechowski
IPC分类号: C07D487/04 , A61K31/519 , C07D495/04 , C07D473/34 , C07D417/04 , C07D403/12 , C07D403/06 , C07D403/04 , C07D239/94 , C07D239/42 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07D471/04 , A61K31/517 , C07H19/16
摘要: The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号:US09670214B2
公开(公告)日:2017-06-06
申请号:US14540919
申请日:2014-11-13
申请人: Nathanael S. Gray , Jianming Zhang , Barun Okram , Xianming Deng
发明人: Nathanael S. Gray , Jianming Zhang , Barun Okram , Xianming Deng
IPC分类号: C07D487/04 , A61K31/519 , C07D471/04 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D495/04 , C07D417/04 , C07D473/34 , A61K31/517 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07H19/16
CPC分类号: C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要: The present invention provides novel heteroaryl compounds of formula (I) having a pyrimidine-containing core that is linked to a 4-trifluoromethoxyphenyl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号:US20100048552A1
公开(公告)日:2010-02-25
申请号:US12299687
申请日:2007-05-11
申请人: Pingda Ren , Baogen Wu , Guobao Zhang , Yongping Xie , Barun Okram , Victor Nikulin , Xia Wang , Ha-Soon Choi
发明人: Pingda Ren , Baogen Wu , Guobao Zhang , Yongping Xie , Barun Okram , Victor Nikulin , Xia Wang , Ha-Soon Choi
IPC分类号: A61K31/4375 , C07D471/14 , A61K31/5377 , A61P43/00
CPC分类号: C07D471/14
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, Bcr-Abl(T315I), ALK, BLK, BMX, BRK, C-kit, c-RAF, CSK, c-SRC, EGFR, Fes, FGFR3, Flt3, Fms, Fyn, IGF-1R, IR, JAK(2), JAK(3), KDR, Lck, NLK, p70S6K, PDGFRα, Ros, SAPK2α, SGK, SIK, Syk, Tie2 and TrkB kinases.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及Abl,Bcr-Abl异常活化的疾病或病症 ,Bcr-Abl(T315I),ALK,BLK,BMX,BRK,C-kit,c-RAF,CSK,c-SRC,EGFR,Fes,FGFR3,Flt3,Fms,Fyn,IGF-1R,IR,JAK( 2),JAK(3),KDR,Lck,NLK,p70S6K,PDGFRα,Ros,SAPK2α,SGK,SIK,Syk,Tie2和TrkB激酶。
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公开(公告)号:US07589101B2
公开(公告)日:2009-09-15
申请号:US12063550
申请日:2006-08-15
申请人: Barun Okram , Pingda Ren , Nathanael S. Gray
发明人: Barun Okram , Pingda Ren , Nathanael S. Gray
IPC分类号: A61K31/407 , A61K31/4162 , A61K31/437 , C07D471/14
CPC分类号: C07D471/14 , C07D495/14
摘要: The invention provides a novel class of compounds of formula I, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the AbI, Bcr-AbI, Aurora-A, SGK, Tie-2, Trk-B, FGFR3, c-kit, b-RAF, c-RAF, DYRK2, Fms, Fyn and PDGFRalpha and PDGFR&bgr; kinases.
摘要翻译: 本发明提供了一类新颖的式I化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及AbI异常活化的疾病或病症, Bcr-AbI,Aurora-A,SGK,Tie-2,Trk-B,FGFR3,c-kit,b-RAF,c-RAF,DYRK2,Fms,Fyn和PDGFRα和PDGFRβ激酶。
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