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    Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same
    5.
    发明授权
    Corynebacteria strain for enhancement of 5′-guanosine monophosphate productivity and a method of producing 5′-guanosine monophosphate using the same 有权
    用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株和使用其制备5'-鸟苷酸单磷酸的方法

    公开(公告)号：US08530200B2

    公开(公告)日：2013-09-10

    申请号：US13140302

    申请日：2009-12-17

    申请人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh ,  Jang Hee Park

    发明人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh ,  Jang Hee Park

    IPC分类号： C12P19/32 ,  C12P19/30

    CPC分类号： C12P19/32 ,  C12N9/0006 ,  Y02P20/582

    摘要： Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.

    摘要翻译： 公开了一种使用具有比野生型高的苹果酸脱氢酶活性的新型微生物生产5'-鸟苷酸单磷酸酯的方法，从而显示出提高的ATP生产率。 另外，公开了一种新型微生物。 该方法包括：培养在内源性活性中苹果酸脱氢酶活性增强的棒状杆菌菌株，从而以高产率产生ATP; 在文化中生产XMP; 向培养基中加入具有XMP胺化活性的酶或微生物; 并从文化中获得GMP。

    Corynebacteria Strain for Enhancement of 5'-Guanosine Monophosphate Productivity and a Method of Producing 5'-Guanosine Monophosphate Using the Same
    6.
    发明申请
    Corynebacteria Strain for Enhancement of 5'-Guanosine Monophosphate Productivity and a Method of Producing 5'-Guanosine Monophosphate Using the Same 有权
    用于增强5'-鸟苷一磷酸生产力的棒状杆菌菌株及使用其制备5'-鸟苷酸单磷酸酯的方法

    公开(公告)号：US20110250651A1

    公开(公告)日：2011-10-13

    申请号：US13140302

    申请日：2009-12-17

    申请人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh

    发明人： Jinman Cho ,  Hye Won Kim ,  Yoon Seok Oh

    IPC分类号： C12P19/32 ,  C12N1/21

    CPC分类号： C12P19/32 ,  C12N9/0006 ,  Y02P20/582

    摘要： Disclosed is a method of producing 5′-guanosine monophosphate using a novel microorganism which has a malate dehydrogenase activity higher than that of a wild-type, thereby showing improved ATP productivity. Also, a novel microorganism is disclosed. The method comprises: culturing the corynebacteria strain which is enhanced in malate dehydrogenase activity over the endogenous activity, thus producing ATP in high yield; producing XMP in the culture; adding to the culture an enzyme or microorganism having XMP amination activity; and obtaining GMP from the culture.

    摘要翻译： 公开了一种使用具有比野生型高的苹果酸脱氢酶活性的新型微生物生产5'-鸟苷酸单磷酸酯的方法，从而显示出提高的ATP生产率。 另外，公开了一种新型微生物。 该方法包括：培养在内源性活性中苹果酸脱氢酶活性增强的棒状杆菌菌株，从而以高产率产生ATP; 在文化中生产XMP; 向培养基中加入具有XMP胺化活性的酶或微生物; 并从文化中获得GMP。

    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME
    8.
    发明申请
    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME 有权
    生产L-阿魏酸的罗丹明葡萄球菌及其制备方法

    公开(公告)号：US20100041109A1

    公开(公告)日：2010-02-18

    申请号：US12522280

    申请日：2008-01-11

    申请人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    发明人： Hye Won Kim ,  Hyejin Choi ,  Ji-Hye Lee ,  Soo Youn Hwang

    IPC分类号： C12P13/10 ,  C12N1/21

    CPC分类号： C12P13/10

    摘要： The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argD2 gene (Ncgl2355) that is a putative gene of acetylornithine aminotransferase involved in arginine biosynthesis of Corynebacterium glutamicum, a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism to overexpress the argD2 gene, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argD2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.

    摘要翻译： 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含argD2基因（Ncgl2355）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的乙酰鸟氨酸氨基转移酶的推定基因，由该多核苷酸编码的多肽，包含多核苷酸的重组载体，能够转化的转化体 通过将重组载体导入产生L-精氨酸的宿主微生物以过表达argD2基因而制备L-精氨酸，以及通过培养转化体来生产L-精氨酸的方法。 本发明的转化体以高产率过表达argD2基因产生L-精氨酸，从而用于医药和制药工业。

    Method for producing L-arginine using Corynebacterium glutamicum
    9.
    发明授权
    Method for producing L-arginine using Corynebacterium glutamicum 有权
    使用谷氨酸棒杆菌生产L-精氨酸的方法

    公开(公告)号：US08034602B2

    公开(公告)日：2011-10-11

    申请号：US12309048

    申请日：2007-07-12

    申请人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    发明人： Young Hoon Park ,  Hye Won Kim ,  Ji-Hye Lee ,  Soo-Youn Hwang

    IPC分类号： C12N1/20 ,  C12P13/10

    CPC分类号： C12R1/15 ,  C12P13/10

    摘要： Disclosed herein are a microorganism producing L-arginine and a method of producing L-arginine using the same. The microorganism is a mutant strain of the genus Corynebacterium, Corynebacterium glutamicum CJR0500. The method for L-arginine production comprises activating the mutant strain C. glutamicum CJR0500 in a fermentation medium at 30° C. for 16 hours and then culturing the activated mutant strain for 72 hours with shaking.

    摘要翻译： 本文公开了生产L-精氨酸的微生物和使用其的L-精氨酸的生产方法。 微生物是棒状杆菌属（Corynebacterium），谷氨酸棒杆菌（Corynebacterium glutamicum）CJR0500的突变菌株。 L-精氨酸生产方法包括在30℃的发酵培养基中活化突变菌株C.谷氨酸棒杆菌CJR0500 16小时，然后摇动培养活化的突变菌株72小时。