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1.发明授权1,2,4-Oxadiazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权1,2,4-恶二唑衍生物作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病公开(公告)号：US07687492B2
公开(公告)日：2010-03-30
申请号：US11587605
申请日：2005-04-29
申请人： Jinyou Xu , Lan Wei , Anthony Mastracchio , Scott D. Edmondson
发明人： Jinyou Xu , Lan Wei , Anthony Mastracchio , Scott D. Edmondson
IPC分类号： A61K31/4245 , A61K31/397 , A61K31/4525 , A61K31/454 , A61P3/10 , C07D271/07 , C07D413/08
CPC分类号： C07D271/06 , C07D413/06 , C07D417/06
摘要： The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新的1,2,4-恶二唑衍生物，其可用于治疗或预防其中二肽基肽酶 - 涉及IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US07157490B2
公开(公告)日：2007-01-02
申请号：US10481352
申请日：2003-11-03
申请人： Vincent J. Colandrea , Scott D. Edmondson , Robert J. Mathvink , Anthony Mastracchio , Ann E. Weber , Jinyou Xu
发明人： Vincent J. Colandrea , Scott D. Edmondson , Robert J. Mathvink , Anthony Mastracchio , Ann E. Weber , Jinyou Xu
IPC分类号： C07D277/04 , C07D207/04 , A61K31/40 , A61K31/426
CPC分类号： C07D205/04 , C07D207/10 , C07D211/38 , C07D213/64 , C07D295/185 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D403/12 , C07D413/10 , C07D413/12 , C07D417/10 , C07D471/04 , C07D487/04
摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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3.发明授权Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of type 2 diabetes 有权β-氨基杂环二肽基肽酶抑制剂用于治疗2型糖尿病公开(公告)号：US08440668B2
公开(公告)日：2013-05-14
申请号：US13086563
申请日：2011-04-14
申请人： Scott D. Edmondson , Michael Fisher , Dooseop Kim , Malcolm MacCoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael Fisher , Dooseop Kim , Malcolm MacCoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/495 , A61K31/40
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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4.发明授权Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment of diabetes 有权β-氨基杂环二肽基肽酶抑制剂治疗糖尿病公开(公告)号：US08168637B2
公开(公告)日：2012-05-01
申请号：US12694758
申请日：2010-01-27
申请人： Scott D. Edmondson , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/50 , A61K31/35 , A61K31/215
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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5.发明申请NOVEL CYCLIC AZABENZIMIDAZOLE DERIVATIVES USEFUL AS ANTI-DIABETIC AGENTS 有权用作抗糖尿病药物的新型CYABAZABENZIMIDAZOLE衍生物公开(公告)号：US20110190308A1
公开(公告)日：2011-08-04
申请号：US13086563
申请日：2011-04-14
申请人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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6.发明申请BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 有权用于治疗或预防糖尿病的β-氨基间苯二酚胰蛋白酶抑制剂公开(公告)号：US20100130504A1
公开(公告)日：2010-05-27
申请号：US12694758
申请日：2010-01-27
申请人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/4985 , A61P3/10
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US07098239B2
公开(公告)日：2006-08-29
申请号：US10481319
申请日：2002-06-19
申请人： Scott D. Edmondson , Emma Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Emma Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： A61K31/40 , C07D207/00
CPC分类号： C07D207/16 , C07D207/26 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/06 , C07D401/12 , C07D403/12 , C07D409/06 , C07D413/12 , C07D417/12
摘要： Compounds having Formula I, including pharmaceutically acceptable salts and prodrugs thereof: (Formula I) are inhibitors of the dipep tidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such as non-insulin dependent diabetes mellitus.
摘要翻译： 具有式I的化合物，包括其药学上可接受的盐和前药：（式I）是二肽基肽酶-IV酶（DP-IV）的抑制剂，可用于治疗DP-IV介导的疾病和病症，例如 非胰岛素依赖性糖尿病。
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8.发明授权Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权β-氨基杂环二肽基肽酶抑制剂，用于治疗或预防糖尿病公开(公告)号：US06699871B2
公开(公告)日：2004-03-02
申请号：US10189603
申请日：2002-07-05
申请人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
发明人： Scott D. Edmondson , Michael H. Fisher , Dooseop Kim , Malcolm Maccoss , Emma R. Parmee , Ann E. Weber , Jinyou Xu
IPC分类号： C07D48704
CPC分类号： A61K31/4985 , A61K31/498 , A61K38/28 , A61K45/06 , C07D487/04 , Y10S514/866 , A61K2300/00
摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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9.发明授权Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病公开(公告)号：US07332520B2
公开(公告)日：2008-02-19
申请号：US10558931
申请日：2004-06-02
IPC分类号： A61K31/403 , C07D209/82 , C07D403/02
CPC分类号： C07D209/88 , C07D209/86 , C07D403/06 , C07D417/06
摘要： The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的稠合吲哚衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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10.发明申请Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes 有权融合氨基哌啶作为二肽基肽酶-4抑制剂治疗或预防糖尿病公开(公告)号：US20090233936A1
公开(公告)日：2009-09-17
申请号：US12085797
申请日：2006-12-08
IPC分类号： A61K31/4985 , C07D471/12 , A61K31/4375 , C07D487/12 , A61K31/519 , A61K31/5025 , A61P3/10
CPC分类号： C07D471/14
摘要： The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.
摘要翻译： 本发明涉及结构式（I）的新型取代的稠合氨基哌啶，其是二肽基肽酶-4酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-4酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-4酶的疾病中的用途。
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