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公开(公告)号：US07393661B2
公开(公告)日：2008-07-01
申请号：US11132814
申请日：2005-05-19
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. This application pertains to nucleic acids encoding a compound, globular OBG3 polypeptide fragments, vectors and transformed host cells containing these nucleic acids and methods of making the globular OBG3 polypeptide fragments.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 本申请涉及编码化合物，球状OBG3多肽片段，载体和含有这些核酸的转化宿主细胞的核酸和制备球状OBG3多肽片段的方法。
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公开(公告)号：US06989367B2
公开(公告)日：2006-01-24
申请号：US10285833
申请日：2002-11-01
IPC分类号： A61K38/17 , A61K38/18 , C07K14/47 , C07K14/475
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026 , Y10S514/909
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。
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公开(公告)号：US06579852B2
公开(公告)日：2003-06-17
申请号：US09909547
申请日：2001-07-19
IPC分类号： A61K3818
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
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公开(公告)号：US07671024B2
公开(公告)日：2010-03-02
申请号：US12126004
申请日：2008-05-23
IPC分类号： A61K38/18 , A61K38/00 , C07K14/435 , C07K14/575
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. The application is related to OBG3 polypepide fragments and compositions comprising these fragments. It also discloses methods of reducing free fatty acid levels with the polypeptide fragments of the invention.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 该应用涉及包含这些片段的OBG3多肽片段和组合物。 它还公开了用本发明的多肽片段降低游离脂肪酸水平的方法。
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公开(公告)号：US20090099076A1
公开(公告)日：2009-04-16
申请号：US12126004
申请日：2008-05-23
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidermias, atherosclerosis, diabetes, and hypertension.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些与肥胖有关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。
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公开(公告)号：US07338787B2
公开(公告)日：2008-03-04
申请号：US10970648
申请日：2004-10-20
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。
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公开(公告)号：US20070275891A1
公开(公告)日：2007-11-29
申请号：US11132814
申请日：2005-05-19
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。
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公开(公告)号：US20050059631A1
公开(公告)日：2005-03-17
申请号：US10970648
申请日：2004-10-20
IPC分类号： A61K38/00 , C07K14/575 , A61K48/00 , C07H21/04
CPC分类号： C07K14/5759 , A61K38/00 , C12N2799/026
摘要： The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.
摘要翻译： 本发明涉及肥胖研究领域。 肥胖是一个严重而广泛的公共卫生问题。 已经鉴定出化合物球状的OBG3，其减少动物的体重增加。 该化合物对于减少体重和治疗与肥胖有关的疾病和病症应该是有效的。 这些肥胖相关的疾病和病症包括高脂血症，动脉粥样硬化，糖尿病和高血压。
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公开(公告)号：US07122644B2
公开(公告)日：2006-10-17
申请号：US10121034
申请日：2002-04-10
申请人： Frances Yen-Potin , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
发明人： Frances Yen-Potin , Blake Denison , Aymeric Duclert , Lydie Bougueleret , Catherine Clusel , Jean-Baptiste Dumas Milne Edwards , Bernard Bihain , Barbara Bour , Dana Ebbets-Reed , Luisa Salter-Cid
IPC分类号： C07H21/04
CPC分类号： C07K16/30 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K14/47 , C07K14/4747 , C07K2319/02 , C07K2319/21 , C07K2319/32 , C12N15/625
摘要： The invention provides the genomic sequence of GSSP-2, GSSP-2 cDNAs and GSSP-2 polypeptides. Further the invention provides polynucleotides including biallelic markers derived from the GSSP-2 gene and from genomic regions flanking the gene. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid molecule containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. The invention also concerns methods and compositions for killing neoplastic cells or inhibiting neoplastic cell growth. In particular, the present invention concerns cell proliferation arresting/inhibiting and apoptosis/necrosis inducing compositions and methods for the treatment of tumors. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides.
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公开(公告)号：US20050075285A1
公开(公告)日：2005-04-07
申请号：US10467554
申请日：2002-02-07
申请人： Barbara Bour , John Chicca , Blake Denison , Frances Yen-Potin , Bernard Bihain , Stephane Bejanin , Hiroaki Tanaka , Severin Jobert , Jean-Yves Giordano , Jean-Baptiste Dumas Milne Edwards
发明人： Barbara Bour , John Chicca , Blake Denison , Frances Yen-Potin , Bernard Bihain , Stephane Bejanin , Hiroaki Tanaka , Severin Jobert , Jean-Yves Giordano , Jean-Baptiste Dumas Milne Edwards
CPC分类号： C07K14/5759 , A61K38/00 , C07K14/775 , Y10S514/909
摘要： The present invention relates to the field of metabolic research. Metabolic disorders, such as obesity, are a public health problem that is serious and widespread. GSSP4 polypeptides have been identified that are believed to be beneficial in the treatment of metabolic disorders. These compounds should be effective for reducing cholesterol levels, body mass, body fat, and for treating metabolic-related diseases and disorders. The metabolic-related diseases or disorders envisioned to be treated by the methods of the invention include, but are not limited to: obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, diabetes, glucose intolerance, insulin resistance and hypertension.
摘要翻译： 本发明涉及代谢研究领域。 代谢紊乱，如肥胖，是一个严重而广泛的公共卫生问题。 已经鉴定出GSSP4多肽被认为在治疗代谢紊乱中是有益的。 这些化合物应有效降低胆固醇水平，体重，体脂肪，以及治疗与代谢有关的疾病和病症。 预期通过本发明的方法治疗的代谢相关疾病或病症包括但不限于：肥胖症，高脂血症，高胆固醇血症，动脉粥样硬化，糖尿病，葡萄糖不耐受，胰岛素抵抗和高血压。
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