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    Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them
    4.
    发明授权
    Terpenoid spiro ketal compounds with LXR agonists activity, their use and formulations with them 有权
    具有LXR激动剂活性的萜类螺旋酮缩酮化合物，它们的用途和配方

    公开(公告)号：US09453016B2

    公开(公告)日：2016-09-27

    申请号：US13994447

    申请日：2011-12-08

    申请人： Torsten Grothe ,  Marc Stadler ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Philipp Wabnitz ,  Thomas Küper

    发明人： Torsten Grothe ,  Marc Stadler ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Philipp Wabnitz ,  Thomas Küper

    IPC分类号： A61K31/35 ,  C07D493/00 ,  C07D471/10 ,  A61K31/56 ,  A61K31/58 ,  A61K36/07

    CPC分类号： C07D471/10 ,  A61K31/56 ,  A61K31/58 ,  A61K36/07

    摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.

    摘要翻译： 本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。 使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。 治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。 本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。 它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。 它们也可以用于非治疗性的，例如， 化妆品，用途。

    Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them
    6.
    发明申请
    Terpenoid Spiro Ketal Compounds with LXR Agonists Activity, Their Use and Formulations with Them 有权
    萜类螺旋酮化合物与LXR激动剂的活性，它们的用途和配方

    公开(公告)号：US20130338219A1

    公开(公告)日：2013-12-19

    申请号：US13994447

    申请日：2011-12-08

    申请人： Torsten Grothe ,  Marc Stadler ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Philipp Wabnitz ,  Thomas Küper

    发明人： Torsten Grothe ,  Marc Stadler ,  Bärbel Köpcke ,  Ernst Roemer ,  Jens Bitzer ,  Philipp Wabnitz ,  Thomas Küper

    IPC分类号： C07D471/10

    CPC分类号： C07D471/10 ,  A61K31/56 ,  A61K31/58 ,  A61K36/07

    摘要： The invention relates to compositions and methods (with regard to animals and humans) for utilizing an extract and/or one or more natural spiro triterpenoids and derivatives thereof alone or as a supplement. Certain materials utilized are from the blazeispirol family, obtainable from Agaricus species. Treatments include the prophylactic and/or therapeutic treatment of a disease, disorder or condition that responds to the modulation of Liver X receptor, as well as corresponding methods of treatment, the manufacture of a pharmaceutical and nutraceutical formulation for said treatment. The invention also relates to the use of the extract and compound(s) in the treatment or in the preparation of a medicament (e.g. a nutraceutical) for the prophylactic and/or therapeutic treatments, as well as their preparation. It also relates to pharmaceutical or nutraceutical formulations described herein which are useful in prophylactic and therapeutic treatments. They can also be used for non-therapeutic, e.g. cosmetic, purposes.

    摘要翻译： 本发明涉及用于单独使用提取物和/或一种或多种天然螺三萜类化合物及其衍生物或作为补充剂的组合物和方法（关于动物和人）。 使用的某些材料来自于可从姬松茸（Agaricus）物种获得的烟草系列。 治疗包括对对肝X受体的调节作出响应的疾病，病症或病状的预防和/或治疗性治疗，以及相应的治疗方法，制备用于所述治疗的药物和营养制剂。 本发明还涉及提取物和化合物在治疗或制备用于预防和/或治疗性治疗的药物（例如营养药物）以及其制备中的用途。 它还涉及可用于预防和治疗性治疗的本文所述的药物或营养制剂。 它们也可以用于非治疗性的，例如， 化妆品，用途。