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公开(公告)号:US06727279B2
公开(公告)日:2004-04-27
申请号:US10225823
申请日:2002-08-21
申请人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
发明人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
IPC分类号: A61K3121
CPC分类号: C07D307/80 , C07C309/65 , C07C2602/08
摘要: The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译: 本发明涉及新的芳基磺酰胺和类似物,其制备方法及其用于预防和治疗神经变性疾病,特别是用于治疗脑中风,颅脑创伤,疼痛和痉挛症的用途。
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公开(公告)号:US06469054B1
公开(公告)日:2002-10-22
申请号:US09763215
申请日:2001-02-16
申请人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
发明人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Victor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl , Klaus-Helmut Mohrs , Siegfried Raddatz , Reinhard Jork
IPC分类号: A61K31343
CPC分类号: C07D307/80 , C07C309/65 , C07C2602/08
摘要: The present invention relates to novel arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译: 本发明涉及新的芳基磺酰胺和类似物,其制备方法及其用于预防和治疗神经变性疾病,特别是用于治疗脑中风,颅脑创伤,疼痛和痉挛症的用途。
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公开(公告)号:US06545050B1
公开(公告)日:2003-04-08
申请号:US09763196
申请日:2001-02-16
申请人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Viktor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl
发明人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jörg Keldenich , Frank Mauler , Jean-Marie-Viktor de Vry , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Michael-Harold Rock , Ervin Horvàth , Arno Friedl
IPC分类号: A61K3140
CPC分类号: C07C309/65 , C07C2602/08 , Y02P20/55
摘要: The present invention relates to novel amino acid esters of arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy, craniocerebral trauma, pain and spasticity.
摘要翻译: 本发明涉及芳基磺酰胺和类似物的新型氨基酸酯,其制备方法及其用于预防和治疗神经变性疾病,特别是用于治疗脑中风,颅脑创伤,疼痛和痉挛状态的用途。
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公开(公告)号:US06525087B2
公开(公告)日:2003-02-25
申请号:US09867021
申请日:2001-05-29
申请人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Arno Friedl , Ervin Horvath , Frank Mauler , Jean-Marie-Viktor De Vry , Reinhard Jork
发明人: Joachim Mittendorf , Jürgen Dressel , Michael Matzke , Jürgen Franz , Peter Spreyer , Verena Vöhringer , Joachim Schumacher , Arno Friedl , Ervin Horvath , Frank Mauler , Jean-Marie-Viktor De Vry , Reinhard Jork
IPC分类号: A61K3138
CPC分类号: A61K31/13 , A61K31/00 , A61K31/05 , A61K31/121 , A61K31/131 , A61K31/16 , A61K31/164 , A61K31/232 , A61K31/352 , A61K31/353 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/436 , A61K31/473 , A61K31/5375 , A61K31/5377 , A61K31/5383
摘要: The present invention relates to the use of known agonists of the central cannabinoid receptor CB1 for the prophylaxis and treatment of neurodegenerative disorders, in particular for the treatment of cerebral apoplexy and craniocerebral trauma.
摘要翻译: 本发明涉及中枢大麻素受体CB1的已知激动剂用于预防和治疗神经变性疾病,特别是用于治疗脑中风和颅脑外伤的用途。
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公开(公告)号:US20130261064A1
公开(公告)日:2013-10-03
申请号:US13876777
申请日:2011-09-26
申请人: Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Srelte Ludwig , Sven Golfier , Joachim Schumacher , Joan Mark Gnoth , Ursula Krenz
发明人: Hans-Georg Lerchen , Sherif El Sheikh , Beatrix Srelte Ludwig , Sven Golfier , Joachim Schumacher , Joan Mark Gnoth , Ursula Krenz
CPC分类号: C07K5/1021 , A61K38/00 , A61K38/07 , A61K38/08 , A61K45/06 , C07K1/1077 , C07K5/0205 , C07K7/02
摘要: The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.
摘要翻译: 本申请涉及通过羧基烷基在N末端被取代的单甲基海洛定蛋白F的新衍生物,用于制备这些衍生物的方法,其用于治疗和/或预防疾病以及产生用于治疗和/或预防 疾病,特别是过度增生和/或血管发生疾病,例如癌症。 这种治疗可以作为单一疗法发生,或与其他药物或其他治疗措施组合发生。
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