Process for preparing cycloheptene
    2.
    发明授权
    Process for preparing cycloheptene 有权
    环庚烯的制备方法

    公开(公告)号:US08993819B2

    公开(公告)日:2015-03-31

    申请号:US13545446

    申请日:2012-07-10

    IPC分类号: C07C6/04 C07C13/24

    摘要: The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closing metathesis of unsymmetric 1,8-dienes whose C—C double bond at the 8 position is nonterminal. Cycloheptene and the cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride conversion products thereof, and the derivatives thereof, are important synthesis units for active ingredient compounds. The ring-closing metathesis is preferably performed as a reactive distillation. The unsymmetric 1,8-dienes for the ring-closing metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation from the corresponding unsaturated carboxylic acids or carboxylic acid derivatives.

    摘要翻译: 本发明提供了一种通过非对称1,8-二烯的闭环复分解来制备环庚烯及其衍生物的方法,其中8位的C-C双键是非末端的。 环庚烯和环庚酮,环庚胺,环庚烷甲醛,环庚烷羧酸和环庚烷碳酰氯的转化产物及其衍生物是活性成分化合物的重要合成单元。 闭环复分解优选作为反应蒸馏进行。 用于闭环复分解的不对称1,8-二烯可以通过相应的不饱和羧酸或羧酸衍生物的催化脱羰或氧化脱羧获得。

    PROCESS FOR PREPARING CYCLOHEPTENE
    3.
    发明申请
    PROCESS FOR PREPARING CYCLOHEPTENE 有权
    制备环孢菌素的方法

    公开(公告)号:US20130018205A1

    公开(公告)日:2013-01-17

    申请号:US13545446

    申请日:2012-07-10

    摘要: The present invention provides a process for preparing cycloheptene and derivatives thereof by ring-closing metathesis of unsymmetric 1,8-dienes whose C—C double bond at the 8 position is nonterminal. Cycloheptene and the cycloheptanone, cycloheptylamine, cycloheptanecarbaldehyde, cycloheptanecarboxylic acid and cycloheptanecarbonyl chloride conversion products thereof, and the derivatives thereof, are important synthesis units for active ingredient compounds. The ring-closing metathesis is preferably performed as a reactive distillation. The unsymmetric 1,8-dienes for the ring-closing metathesis can be obtained by catalytic decarbonylation or oxidative decarboxylation from the corresponding unsaturated carboxylic acids or carboxylic acid derivatives.

    摘要翻译: 本发明提供了一种通过非对称1,8-二烯的闭环复分解来制备环庚烯及其衍生物的方法,其中8位的C-C双键是非末端的。 环庚烯和环庚酮,环庚胺,环庚烷甲醛,环庚烷羧酸和环庚烷碳酰氯的转化产物及其衍生物是活性成分化合物的重要合成单元。 闭环复分解优选作为反应蒸馏进行。 用于闭环复分解的不对称1,8-二烯可以通过相应的不饱和羧酸或羧酸衍生物的催化脱羰或氧化脱羧获得。