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19 条记录 (耗时 0.018 秒)

    Method of purifying ferment-produced riboflavin
    1.
    发明授权
    Method of purifying ferment-produced riboflavin 失效
    净化发酵的RIBOFLAVIN的方法

    公开(公告)号：US5210023A

    公开(公告)日：1993-05-11

    申请号：US724056

    申请日：1991-07-01

    申请人： Johannes Grimmer ,  Hans Kiefer ,  Christoph Martin

    发明人： Johannes Grimmer ,  Hans Kiefer ,  Christoph Martin

    IPC分类号： C07D475/14 ,  C12P17/18

    CPC分类号： C07D475/14

    摘要： A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75.degree. to 130.degree. C. for from 0.3 to 3 hours with stirring, during which time crystal transformation takes place, after which the mixture is cooled and the purified product is isolated in known manner.

    摘要翻译： 一种纯化发酵生产的核黄素的方法，其中不纯的核黄素悬浮在水中或稀释酸水溶液，悬浮液在75-130℃的温度下搅拌加热0.3-3小时，在此期间 发生时间晶体转变，然后将混合物冷却，以已知方式分离纯化产物。

    Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt in a lactone
    5.
    发明授权
    Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt in a lactone 失效
    五磷酸五磷酸（FMN）及其盐中的盐酸盐的制备

    公开(公告)号：US5095115A

    公开(公告)日：1992-03-10

    申请号：US571230

    申请日：1990-08-23

    申请人： Johannes Grimmer ,  Hans Kiefer

    发明人： Johannes Grimmer ,  Hans Kiefer

    IPC分类号： A61K31/675 ,  A61P3/02 ,  C07F9/6524 ,  C07F9/6561 ,  C07F9/6574

    CPC分类号： C07F9/65618 ,  C07F9/65742

    摘要： An improved process for preparing riboflavin 5'-phosphate (FMN) or its monosodium salt by reacting riboflavin with excess phosphorus oxychloride in a solvent, hydrolyzing of the resulting reaction mixture and, if desired, partially neutralizing with aqueous sodium hydroxide solution, comprises reacting the riboflavin with from 1.2 to 3 moles of phosphorus oxychloride per mole of riboflavin in a suitable lactone, especially .gamma.-butyrolactone, as solvent. The process is particularly advantageous when the reaction mixture is hydrolyzed at from 80.degree. to 90.degree. C. continuously or batchwise.

    摘要翻译： 通过使核黄素与过量的三氯氧化磷在溶剂中反应制备核黄素5'-磷酸（FMN）或其单钠盐的改进方法，水解所得反应混合物，如果需要，用氢氧化钠水溶液部分中和， 在适当的内酯，特别是γ-丁内酯中，每摩尔核黄素使用1.2至3摩尔磷酰氯的核黄素作为溶剂。 当反应混合物连续或间歇地在80℃至90℃下水解时，该方法特别有利。

    Stereoselective preparation of (-) 3a,6,6,9a-tetramethyl-perhydronaphtho[2,1-b]furan
    6.
    发明授权
    Stereoselective preparation of (-) 3a,6,6,9a-tetramethyl-perhydronaphtho[2,1-b]furan 失效
    （ - ）3a，6,6,9a-四甲基 - 过氢萘并[2,1-b]呋喃的立体选择性制备

    公开(公告)号：US5616737A

    公开(公告)日：1997-04-01

    申请号：US674914

    申请日：1996-07-03

    申请人： Johannes Grimmer ,  Christoph Martin

    发明人： Johannes Grimmer ,  Christoph Martin

    IPC分类号： B01J21/04 ,  C07B53/00 ,  C07B61/00 ,  C07D307/92 ,  C11B9/00

    CPC分类号： C07D307/92

    摘要： A process for the stereoselective preparation of (-)3a,6,6,9a-tetramethylperhydronaphtho[2,1-b]furan of the formula Ia ##STR1## by dehydration and cyclization of decahydro-2-hydroxy- 2,5,5,8-tetramethyl-1-naphthaleneethanol using solid acidic catalysts, wherein the decahydro-2-hydroxy- 2,5,5,8-tetramethyl-1-naphthaleneethanol is heated in the molten state at from 80.degree. to 200.degree. C. in the presence of from 10 to 100% by weight, based on the diol, of an active acidic aluminum oxide commercially supplied for (preparative) column chromatography.

    摘要翻译： 通过脱水和环化十氢-2-羟基-2的立体选择性制备式（Ia）的（ - ）3a，6,6,9a-四氢呋喃并[2,1-b]呋喃的方法， 5,5,8-四甲基-1-萘乙醇使用固体酸性催化剂，其中十氢-2-羟基-2,5,5,8-四甲基-1-萘乙醇在80〜200℃的熔融状态下加热 在10至100重量％的存在下，基于二醇，市售的（制备型）柱色谱法的活性酸性氧化铝。

    Removal of riboflavin from fermentation suspensions
    7.
    发明授权
    Removal of riboflavin from fermentation suspensions 失效
    从发酵悬浮液中除去RIBOFLAVIN

    公开(公告)号：US5169759A

    公开(公告)日：1992-12-08

    申请号：US644609

    申请日：1991-01-23

    申请人： Tillmann Faust ,  Joachim Meyer ,  Georg Wellinghoff ,  Walter Gosele ,  Christoph Martin ,  Johannes Grimmer

    发明人： Tillmann Faust ,  Joachim Meyer ,  Georg Wellinghoff ,  Walter Gosele ,  Christoph Martin ,  Johannes Grimmer

    IPC分类号： C07D475/14 ,  C12P17/18 ,  C12P25/00

    CPC分类号： C12P25/00

    摘要： Riboflavin is removed from fermentation suspensions by them being heated at from 50.degree. to 90.degree. C. for from 1 to 3 hours, than cooled to from 0.degree. to 30.degree. C. over a period of from 1 to 5 hours, and subsequently being centrifuged to give a sediment fraction and liquid fraction in such a way that the sediment fraction contains predominantly riboflavin crystals as solid, and the liquid fraction contains virtually no crystalline riboflavin, and, where appropriate, resuspending the sediment fraction in from 0.5 to 2 parts by volume of water per part by volume of sediment fraction and repeating procedure c.

    摘要翻译： 将核黄素从发酵悬浮液中除去，在50〜90℃下加热1〜3小时，冷却至0〜30℃，时间为1〜5小时，随后为 离心分离以得到沉淀物部分和液体部分，使得沉淀物部分主要含有核黄素晶体作为固体，并且液体部分几乎不含结晶核黄素，并且在适当情况下将沉降物组分重悬于0.5至2份中 每部分体积的沉淀物含量的水量和重复程序c。

    Preparation of anthranilic acid amides
    8.
    发明授权
    Preparation of anthranilic acid amides 失效
    邻氨基苯甲酰胺的制备

    公开(公告)号：US4421931A

    公开(公告)日：1983-12-20

    申请号：US338243

    申请日：1982-01-11

    申请人： Peter Tonne ,  Winfried Ludwig ,  Gerhard Kilpper ,  Johannes Grimmer

    发明人： Peter Tonne ,  Winfried Ludwig ,  Gerhard Kilpper ,  Johannes Grimmer

    IPC分类号： C07C231/00 ,  C07C233/00 ,  C07C102/04 ,  C07C103/28 ,  C07C103/76

    CPC分类号： C07C231/00 ,  C07C233/00

    摘要： Anthranilic acid amides are prepared by mixing phthalamic acid with a caustic alkali solution, a catalyst and a hypohalite, allowing the mixture to stand for from 1 to 1,000 seconds, then introducing the amine and thereafter addig acid until the pH of the mixture is from 6 to 8.The anthranilic acid amides obtainable by the process of the invention are valuable starting materials for the preparation of dyes, scents and pesticides.

    摘要翻译： 邻氨基苯甲酸酰胺通过将邻苯二甲酰氨基磺酸与苛性碱溶液，催化剂和次卤酸盐混合，使混合物静置1至1,000秒，然后引入胺然后加入酸直至混合物的pH为6 通过本发明的方法获得的邻氨基苯甲酰胺是用于制备染料，香料和农药的有价值的原料。

    Method for Reducing Alkyne Compuonds
    9.
    发明申请
    Method for Reducing Alkyne Compuonds 审中-公开
    减少炔烃的方法

    公开(公告)号：US20070219383A1

    公开(公告)日：2007-09-20

    申请号：US11662440

    申请日：2005-09-08

    申请人： Johannes Grimmer ,  Thomas Muller

    发明人： Johannes Grimmer ,  Thomas Muller

    IPC分类号： C07D317/64 ,  C01C1/00 ,  C07C403/08 ,  C07C45/00

    CPC分类号： C07C403/24 ,  C07C403/08 ,  C07C2601/16

    摘要： The present invention relates to a method for preparing cyclohexene derivatives of the general formulae I or II by reducing alkyne compounds of the general formulae III or IV with a mixture of zinc and at least one ammonium salt of the formula V as reducing agent, in which the substituents R1 to R8 have independently of one another the meaning specified in the description, wherein the reducing agent comprises from 0.3 to 0.49 mol of at least one ammonium salt of the formula V per mol of zinc.

    摘要翻译： 本发明涉及通过用通式Ⅴ的锌和至少一种铵盐作为还原剂的混合物还原通式III或Ⅳ的炔化合物来制备通式I或II的环己烯衍生物的方法，其中 取代基R 1至R 8彼此独立地具有说明书中指定的含义，其中还原剂包含0.3至0.49mol的至少一种铵盐 式V每摩尔锌。

    Preparation of riboflavin
    10.
    发明授权
    Preparation of riboflavin 失效
    核黄素的制备

    公开(公告)号：US4806643A

    公开(公告)日：1989-02-21

    申请号：US932312

    申请日：1986-11-19

    申请人： Johannes Grimmer

    发明人： Johannes Grimmer

    IPC分类号： C07D475/14

    CPC分类号： C07D475/14

    摘要： Riboflavin of the formula I ##STR1## is prepared by an improved process by condensing a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II ##STR2## where R is H, --CL, --NO.sub.2, --CH.sub.3 or --OCH.sub.3 in the o- or p-position, with barbituric acid of the formula III ##STR3## in the presence of an acid as a condensing agent, by a process in which the acidic condensing agent used is an aliphatic secondary carboxylic acid of the general formula IV ##STR4## where R.sup.1 is methyl or ethyl and R.sup.2 is alkyl of 3 or 4 carbon atoms.

    摘要翻译： 式I（I）的核黄素通过将下式（II）的4,5-二甲基-N-（D） - 二基-2-苯基偶氮苯胺缩合得到改进的方法来制备，其中R是 H，-CL，-NO 2，-CH 3或-OCH 3与通式III的巴比妥酸（III）在作为缩合剂的酸存在下，通过在 其中使用的酸性缩合剂是通式IV（IV）的脂族二羧酸，其中R 1是甲基或乙基，R 2是3或4个碳原子的烷基。