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公开(公告)号:US20080096856A1
公开(公告)日:2008-04-24
申请号:US11661466
申请日:2005-09-16
申请人: John Barrett , Kithsiri Herath , Hiranthi Jayasuriya , Prakash Masurekar , John Ondeyka , Sheo Singh , Chaowei Zhang
发明人: John Barrett , Kithsiri Herath , Hiranthi Jayasuriya , Prakash Masurekar , John Ondeyka , Sheo Singh , Chaowei Zhang
IPC分类号: A61K31/33 , A61P43/00 , C07D513/22 , C12P17/18
摘要: Fermentation of a nutrient medium with a Nocardia spp. yields a novel broad spectrum antibiotic compound of structural formula (I) or a pharmaceutically acceptable salt, ester, enantiomer, diasteriomer or mixture.
摘要翻译: 用诺卡氏菌发酵营养培养基 产生结构式(I)的新型广谱抗生素化合物或其药学上可接受的盐,酯,对映异构体,非对映异构体或混合物。
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公开(公告)号:US5091389A
公开(公告)日:1992-02-25
申请号:US690407
申请日:1991-04-23
申请人: John Ondeyka , Otto Hensens , Jerrold Liesch
发明人: John Ondeyka , Otto Hensens , Jerrold Liesch
IPC分类号: A61K31/435 , A61P31/04 , A61P37/06 , C07D498/18 , C12P17/18 , C12R1/55
CPC分类号: C07D498/18
摘要: Disclosed is a novel lipophilic macrolide of assigned Formula I: ##STR1## The compound of assigned Formula I is an analog of rapamycin which has activity as an antifungal agent and as an immunosuppressant.
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