Coating for controlled release of a therapeutic agent
    1.
    发明申请
    Coating for controlled release of a therapeutic agent 审中-公开
    用于治疗剂的控制释放的涂层

    公开(公告)号:US20050033417A1

    公开(公告)日:2005-02-10

    申请号:US10883328

    申请日:2004-07-01

    摘要: Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

    摘要翻译: 可以涂覆医疗装置,特别是可植入医疗装置,以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物,药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物,药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外,这些治疗药物,药剂和/或化合物可用于促进愈合,包括血块的形成。 此外,可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物,试剂或化合物维持在医疗装置上,直到输送和定位。 此外,可以修改用于递送可植入医疗装置的装置,以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架,移植物,吻合装置,血管周围包裹物,缝线和钉。 此外,可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物,药剂和/或化合物的洗脱速率。

    Method of implating a medical device using a suture tab extender
    2.
    发明申请
    Method of implating a medical device using a suture tab extender 有权
    使用缝合线扩张器来植入医疗装置的方法

    公开(公告)号:US20070173685A1

    公开(公告)日:2007-07-26

    申请号:US11489752

    申请日:2006-07-20

    IPC分类号: A61F2/00

    摘要: A method of implanting a surgically implantable band, the method comprising the steps of providing a band with an elongated body member having a first end with a first latching member positioned thereon, and a second end with a second latching member positioned thereon. The first latching member has a suture tab extender extending therefrom. The suture tab extender has a suture attached thereto. The second end has a gripping section positioned thereon shaped and dimensioned to facilitate gripping as the gastric band extender is passed through the second latching member. The method further includes the step of positioning the band around an anatomical structure and latching the band around the structure by placing the suture tab extender through the second latching member and thereafter coupling the first and second latching members. The method further involves the step of removing the suture tab extender from the band.

    摘要翻译: 一种植入手术可植入带的方法,所述方法包括以下步骤:提供具有细长主体构件的带,所述细长主体构件具有第一端部,其具有定位在其上的第一闩锁构件,以及具有定位在其上的第二闩锁构件的第二端。 第一闭锁构件具有从其延伸的缝合线片延伸器。 缝合线扩张器具有附接到其上的缝合线。 第二端具有定位在其上的抓握部分,其形状和尺寸被设计成当胃带延伸器穿过第二闩锁部件时便于抓握。 该方法还包括将带定位在解剖结构周围并通过将缝合线片延伸器放置穿过第二闩锁构件并且此后联接第一和第二闩锁构件而将带锁定在结构周围的步骤。 该方法进一步包括从带中去除缝合线片延伸器的步骤。

    Distal protection filter with improved wall apposition
    3.
    发明申请
    Distal protection filter with improved wall apposition 审中-公开
    远端保护过滤器,具有改进的墙壁配合

    公开(公告)号:US20070225748A1

    公开(公告)日:2007-09-27

    申请号:US11026309

    申请日:2004-12-30

    IPC分类号: A61F2/01

    摘要: In accordance with the present invention, a distal protection and embolic material retrieval device with improved apposition to both large and small vessel walls of varying geometries for enhancing the filtering of embolic material during intravascular procedures while allowing for the passage of blood is provided. The device includes a filter basket designed to maximize apposition of the filtering portion to that of the vessel wall and may include struts which provide circumferential support to the filtering membrane and thereby minimizing or eliminating in-folding of the filter basket. Thin film materials may also be utilized for the filtering membrane of the filter basket. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.

    摘要翻译: 根据本发明,提供一种远程保护和栓塞材料回收装置,其具有改进的与不同几何形状的大血管壁和小血管壁的相适应,用于在血管内手术期间增强血栓过程中的过滤,同时允许血液通过。 该装置包括过滤篮,该过滤篮设计成使过滤部分最大程度地与容器壁的配合最大化,并且可以包括为过滤膜提供圆周支撑并由此最小化或消除过滤篮的折叠的支柱。 薄膜材料也可用于过滤篮的过滤膜。 此外,可以结合本发明并入生物和/或药剂。

    Method for the surface modification of silicone surfaces
    4.
    发明申请
    Method for the surface modification of silicone surfaces 审中-公开
    硅树脂表面改性方法

    公开(公告)号:US20050079365A1

    公开(公告)日:2005-04-14

    申请号:US10820139

    申请日:2004-04-08

    摘要: Disclosed is a method for modifying the surface properties of a silicone or siloxane-based polymer or copolymer substrate comprising, (1) exposing the surface to a basic aqueous resolution comprising a substance capable of graft-polymerization with the silicone or siloxane-based polymer or copolymer substrate, the aqueous solution having a pH above about 8.0, the exposure to the basic aqueous solution being for a time sufficient to enhance the graft-polymerization and (2) subjecting the surface and basic solution to conditions whereby the polymerizable substance is polymerized to form a graft-polymerized coating on the surface. Also disclosed are compositions of matter prepared by the above-described process as well as articles manufactured therefrom.

    摘要翻译: 公开了一种用于改性硅氧烷或硅氧烷基聚合物或共聚物基材的表面性质的方法,其包括:(1)将表面暴露于含有能够与硅氧烷或硅氧烷基聚合物接枝聚合的物质的碱性含水分辨率,或 共聚物底物,pH高于约8.0的水溶液,暴露于碱性水溶液的时间足以增加接枝聚合的时间,和(2)使表面和碱性溶液经受聚合物质聚合的条件 在表面上形成接枝聚合的涂层。 还公开了通过上述方法制备的物质的组合物以及由其制造的制品。

    Gastric band suture tab extender
    5.
    发明申请
    Gastric band suture tab extender 有权
    胃带缝线扩张器

    公开(公告)号:US20070016229A1

    公开(公告)日:2007-01-18

    申请号:US11364361

    申请日:2006-03-01

    IPC分类号: A61B17/08

    摘要: A removable suture tab extender for a gastric band is shaped and dimensioned for selective attachment to a first end of the gastric band, the gastric band including a latching mechanism composed of a first latching member positioned at the first end of the gastric band and a second latching member positioned at a second end of the gastric band. The gastric band extender includes an elongated body member having a first end and a second end. The first end of the elongated body member is shaped and dimensioned for coupling with the first latching member. The second end of the elongated body member includes a gripping section shaped and dimensioned to facilitate gripping thereof as the gastric band extender is passed through the second latching member.

    摘要翻译: 用于胃带的可移除缝合线扩张器的形状和尺寸用于选择性地附接到胃带的第一端,胃带包括由位于胃束带的第一端的第一锁定构件构成的闩锁机构, 锁定构件位于胃束带的第二端。 胃带延长器包括具有第一端和第二端的细长主体构件。 细长主体构件的第一端的形状和尺寸用于与第一闭锁构件联接。 细长主体构件的第二端包括形状和尺寸的抓握部分,以便在胃带延伸器穿过第二闩锁构件时便于抓握。

    Distal protection apparatus with improved wall apposition
    6.
    发明申请
    Distal protection apparatus with improved wall apposition 审中-公开
    远距保护装置,具有改善的墙壁配合

    公开(公告)号:US20060149313A1

    公开(公告)日:2006-07-06

    申请号:US11026377

    申请日:2004-12-30

    IPC分类号: A61M29/00

    摘要: In accordance with the present invention, a distal protection and embolic material retrieval device with improved apposition to both large and small vessel walls of varying geometries for enhancing the filtering of embolic material during intravascular procedures while allowing for the passage of blood is provided. The device includes a filter basket designed to maximize apposition of the filtering portion to that of the vessel wall and may include struts which provide circumferential support to the filtering membrane and thereby minimizing or eliminating in-folding of the filter basket. Thin film materials may also be utilized for the filtering membrane of the filter basket. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.

    摘要翻译: 根据本发明,提供一种远程保护和栓塞材料回收装置,其具有改进的与不同几何形状的大血管壁和小血管壁的相适应,用于在血管内手术期间增强血栓过程中的过滤,同时允许血液通过。 该装置包括过滤篮,该过滤篮设计成使过滤部分最大程度地与容器壁的配合最大化,并且可以包括为过滤膜提供圆周支撑并由此最小化或消除过滤篮的折叠的支柱。 薄膜材料也可用于过滤篮的过滤膜。 此外,可以结合本发明并入生物和/或药剂。

    CONTROLLING PRESSURE IN ADJUSTABLE RESTRICTION DEVICES
    7.
    发明申请
    CONTROLLING PRESSURE IN ADJUSTABLE RESTRICTION DEVICES 有权
    在可调节的限制装置中控制压力

    公开(公告)号:US20090171375A1

    公开(公告)日:2009-07-02

    申请号:US11965331

    申请日:2007-12-27

    IPC分类号: A61B17/12

    CPC分类号: A61F5/0059

    摘要: Methods and devices are provided for regulating a hydraulic restriction system including a restriction device. In general, the methods and devices can allow for non-invasive, transient pressure control. The methods and devices can also, in some embodiments, mechanically regulate pressure of the restriction device without using any electrical components that may need to be powered to operate over extended periods of time.

    摘要翻译: 提供了用于调节包括​​限制装置的液压限制系统的方法和装置。 通常,这些方法和装置可以允许非侵入式瞬时压力控制。 在一些实施例中,方法和装置也可以机械地调节限制装置的压力,而不使用可能需要被供电以在延长的时间段内操作的任何电气部件。

    Distal protection device with improved wall apposition
    8.
    发明申请
    Distal protection device with improved wall apposition 审中-公开
    远端保护装置,具有改进的墙壁配合

    公开(公告)号:US20060149312A1

    公开(公告)日:2006-07-06

    申请号:US11026308

    申请日:2004-12-30

    IPC分类号: A61M29/00

    摘要: In accordance with the present invention, a distal protection and embolic material retrieval device with improved apposition to both large and small vessel walls of varying geometries for enhancing the filtering of embolic material during intravascular procedures while allowing for the passage of blood is provided. The device includes a filter basket designed to maximize apposition of the filtering portion to that of the vessel wall and may include struts which provide circumferential support to the filtering membrane and thereby minimizing or eliminating in-folding of the filter basket. Thin film materials may also be utilized for the filtering membrane of the filter basket. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.

    摘要翻译: 根据本发明,提供一种远程保护和栓塞材料回收装置,其具有改进的与不同几何形状的大血管壁和小血管壁的相适应,用于在血管内手术期间增强血栓过程中的过滤,同时允许血液通过。 该装置包括过滤篮,该过滤篮设计成使过滤部分最大程度地与容器壁的配合最大化,并且可以包括为过滤膜提供圆周支撑并由此最小化或消除过滤篮的折叠的支柱。 薄膜材料也可用于过滤篮的过滤膜。 此外,可以结合本发明并入生物和/或药剂。

    Articulating surgical instrument
    9.
    发明申请
    Articulating surgical instrument 审中-公开
    铰接手术器械

    公开(公告)号:US20070185519A1

    公开(公告)日:2007-08-09

    申请号:US11352471

    申请日:2006-02-07

    IPC分类号: A61B17/00

    摘要: A method for aiding a surgical procedure, the method uses the steps of providing a surgical instrument with an elongated shaft having a distal end, a proximal end and a longitudinal axis therebetween, the distal end having an end effector attached thereto, the shaft having a first strip running along the longitudinal axis and attached to the end effector, and a second strip, parallel to the first strip, running along the longitudinal axis from the distal end of the shaft to the distal end of the end effector where it is attached thereto, the end effector comprising a plurality of spaced apart links disposed along the longitudinal axis between the distal end of the end effector the distal end of the shaft such that the strips run through the links, and each link is attached to at least one strip. The method also includes the steps of inserting the instrument to a desired location in a body and curving the instrument by moving the first strip proximally. The method also includes the steps of preventing the first strip from moving proximally beyond a predetermined amount and thereby causing the end effector to bend only up to a predetermined angle, and preventing the links from making contact with one another.

    摘要翻译: 一种用于辅助外科手术的方法,所述方法使用以下步骤:为外科器械提供细长轴,所述细长轴具有远端,近端和其间的纵向轴线,所述远端具有连接到其上的末端执行器,所述轴具有 第一条带沿着纵向轴线延伸并且附接到末端执行器,以及平行于第一条带的第二条带,沿着纵向轴线从轴的远端延伸到末端执行器的远端,在其附接到其上 末端执行器包括沿着纵向轴线设置的多个间隔开的连接件,该端部位于端部执行器的远端之间的轴的远端,使得条带穿过链节,并且每个连接件附接到至少一个条带。 该方法还包括以下步骤:将仪器插入身体中的期望位置并通过向近侧移动第一条来弯曲仪器。 该方法还包括以下步骤:防止第一条带向近侧移动超过预定量,从而使端部执行器仅弯曲至预定角度,并且防止连杆彼此接触。

    Deployment system for an intraluminal medical device
    10.
    发明申请
    Deployment system for an intraluminal medical device 审中-公开
    管腔内医疗器械的部署系统

    公开(公告)号:US20070106364A1

    公开(公告)日:2007-05-10

    申请号:US11270292

    申请日:2005-11-09

    IPC分类号: A61F2/06

    CPC分类号: A61F2/95 A61F2250/0018

    摘要: An intraluminal medical device delivery system that distributes forces more uniformly across an intraluminal medical device during loading and delivery of the device to an intended treatment site. A support member provided on an inner member of a catheter delivery system helps to more uniformly distribute forces across the device by crimping the device over the support member so as to place the support member in a mechanically compressed state during delivery of the device to the intended treatment site. The support member is preferably comprised of a material having a modulus of elasticity that increases when the material is compressed. The mechanical nature of the support member provides increased stability to the device during loading and delivery thereof without providing heat or other preformed or additional mechanical members to the support member. Repositioning of the device is available due to the stability of the device when mounted on the support member. The intraluminal medical device can be a stent, a stent graft, segments thereof, or a series of such stents, stent grafts, or segments thereof.

    摘要翻译: 一种管腔内医疗装置输送系统,其在将装置装载和输送到预期治疗部位期间更均匀地分布在管腔内医疗装置上。 设置在导管输送系统的内部构件上的支撑构件有助于通过将装置压靠在支撑构件上而使装置更加均匀地分布在装置上,以便在将装置输送到期望的位置时将支撑构件置于机械压缩状态 治疗部位。 支撑构件优选地包括当材料被压缩时增加的弹性模量的材料。 支撑构件的机械性质在装载和输送装置期间提供了对装置的增加的稳定性,而不向支撑构件提供热或其它预成型或附加的机械构件。 由于设备安装在支撑构件上时的稳定性,可以重新定位设备。 管腔内医疗装置可以是支架,支架移植物,其片段或一系列这种支架,支架移植物或其片段。