公开(公告)号：US20050033417A1

公开(公告)日：2005-02-10

申请号：US10883328

申请日：2004-07-01

申请人： John Borges ,  Maritza Carballo ,  Pallassana Narayanan ,  William Shaw ,  Christopher Widenhouse

发明人： John Borges ,  Maritza Carballo ,  Pallassana Narayanan ,  William Shaw ,  Christopher Widenhouse

IPC分类号： A61B17/04 ,  A61B17/11 ,  A61B17/115 ,  A61F2/84 ,  A61K9/00 ,  A61K31/395 ,  A61K31/436 ,  A61L27/28 ,  A61L27/34 ,  A61L27/54 ,  A61L31/00 ,  A61L31/10 ,  A61L31/16 ,  A61P9/10 ,  A61F2/06

CPC分类号： A61K9/0024 ,  A61K31/395 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08 ,  C08L33/10 ,  C08L27/16

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。 可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。 此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。 医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US20090082855A1

公开(公告)日：2009-03-26

申请号：US12327357

申请日：2008-12-03

申请人： John Borges ,  Maritza Carballo ,  Pallassana V. Narayanan ,  William D. Shaw, JR. ,  Christopher W. Widenhouse

发明人： John Borges ,  Maritza Carballo ,  Pallassana V. Narayanan ,  William D. Shaw, JR. ,  Christopher W. Widenhouse

IPC分类号： A61F2/82

CPC分类号： A61K9/0024 ,  A61K31/395 ,  A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/08 ,  C08L33/10 ,  C08L27/16

摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Also, the devices may be modified to promote endothelialization. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.

摘要翻译： 可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。 医疗装置可以涂覆任何数量的生物相容性材料。 治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。 这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。 此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。 此外，可以修改装置以促进内皮化。 此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

公开(公告)号：US20070213136A1

公开(公告)日：2007-09-13

申请号：US11371791

申请日：2006-03-09

申请人： John Borges ,  Vail Trevisanut ,  David Scarr

发明人： John Borges ,  Vail Trevisanut ,  David Scarr

IPC分类号： F16C3/00

CPC分类号： F16C3/023

摘要： Provided is a torque tube assembly comprising a hollow composite member and an end fitting. The composite member has at least one end portion divided into a forward section and an aft section. The forward section is disposed adjacent a free end of the composite member. Each one of the forward and aft sections has at least one lobe extending radially outwardly along a lobe axis. The lobe axis of the forward section is preferably angularly offset from the lobe axis of the aft section. The end fitting is formed complementary to the composite member and is at least partially enclosed by the forward and aft sections.

摘要翻译： 提供了一种扭矩管组件，其包括中空复合构件和端部配件。 复合构件具有分成前部和后部的至少一个端部。 前部部分邻近复合构件的自由端设置。 前部和后部中的每一个具有至少一个沿着叶轴径向向外延伸的凸角。 前段的叶轴优选地与后段的叶轴成角度偏移。 端部配件与复合构件互补形成，并且至少部分地被前部和后部部分包围。

公开(公告)号：US4898994A

公开(公告)日：1990-02-06

申请号：US257981

申请日：1988-10-14

申请人： Glen L. Livingston ,  John Borges ,  George L. Mina

发明人： Glen L. Livingston ,  John Borges ,  George L. Mina

IPC分类号： C07C37/16 ,  C07C37/18 ,  C07C39/15

CPC分类号： C07C37/16

摘要： 3,5-di-alkyl-4-hydroxybenzyl-substituted aromatics are made in improved yield by co-feeding 2,6-di-alkyl-4-alkoxymethyl phenol and sulfuric acid to a benzene compound, e.g. mesitylene, in an inert solvent at -10.degree. to 50.degree. C.