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44 条记录 (耗时 0.059 秒)

    Furanopyrimidines
    1.
    发明申请
    Furanopyrimidines 有权
    呋喃并嘧啶

    公开(公告)号：US20060040961A1

    公开(公告)日：2006-02-23

    申请号：US11169312

    申请日：2005-06-29

    申请人： John Buchanan ,  William Buckner ,  Simon Burkitt ,  Erin DiMauro ,  Christopher Farthing ,  Alexander Frenkel ,  Martin Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah Lively ,  Teresa Marshall ,  David McGowan ,  Rajiv Sharma ,  Stephen Shuttleworth ,  Xiaotian Zhu

    发明人： John Buchanan ,  William Buckner ,  Simon Burkitt ,  Erin DiMauro ,  Christopher Farthing ,  Alexander Frenkel ,  Martin Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah Lively ,  Teresa Marshall ,  David McGowan ,  Rajiv Sharma ,  Stephen Shuttleworth ,  Xiaotian Zhu

    IPC分类号： A61K31/519 ,  C07D491/02

    CPC分类号： C07D491/04 ,  C07D495/04

    摘要： The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

    摘要翻译： 本发明涉及具有通式I的呋喃并嘧啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，治疗哺乳动物各种疾病和病症的方法，包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风， 多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹， 结肠癌和胸腺瘤，包括向哺乳动物施用治疗有效量的式I化合物。本发明还涉及制备药物的方法，其包含一种或多种式I化合物。

    Substituted heterocyclic compounds and methods of use
    5.
    发明申请
    Substituted heterocyclic compounds and methods of use 失效
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050026914A1

    公开(公告)日：2005-02-03

    申请号：US10891636

    申请日：2004-07-13

    申请人： John Buchanan ,  Daniel Elbaum ,  Matthew Martin ,  David McGowan ,  Perry Novak ,  Joseph Nunes

    发明人： John Buchanan ,  Daniel Elbaum ,  Matthew Martin ,  David McGowan ,  Perry Novak ,  Joseph Nunes

    IPC分类号： A61P37/00 ,  C07D213/75 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/541 ,  A61K31/506 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02 ,  C07

    CPC分类号： C04B35/632 ,  C07D213/75 ,  C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04

    摘要： The present invention relates to pyrimidine or pyridine carbamate compounds having the general Formula I: and pharmaceutically acceptable salts or derivatives thereof. Also included are methods of treatment of various diseases and conditions, including inflammation, inhibition of T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma, thymoma, just to name a few, in a mammal, the methods comprising administering a therapeutically-effective amount a compound of Formula I, or a salt or derivative form thereof, as described above.

    摘要翻译： 本发明涉及具有通式I的嘧啶或吡啶氨基甲酸酯化合物及其药学上可接受的盐或衍生物。 还包括治疗各种疾病和病症的方法，包括炎症，T细胞活化和增殖的抑制，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风，多发性硬化，炎性肠病，克罗恩病，狼疮， 超敏反应，1型糖尿病，牛皮癣，皮炎，桥本甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹，癌症，结肠癌，胸腺瘤，仅举几例 哺乳动物，所述方法包括给予治疗有效量的如上所述的式I化合物或其盐或衍生物形式。

    High-pressure tubing
    6.
    发明授权
    High-pressure tubing 有权
    高压管

    公开(公告)号：US08696903B2

    公开(公告)日：2014-04-15

    申请号：US12067216

    申请日：2006-09-14

    申请人： John Buchanan ,  Dennis DellaRovere

    发明人： John Buchanan ,  Dennis DellaRovere

    IPC分类号： B01D15/08

    CPC分类号： G01N30/88 ,  B01L3/502753 ,  B01L3/565 ,  B01L2400/0415 ,  B01L2400/0487 ,  B29C63/18 ,  B29C63/34 ,  B29L2023/00 ,  G01N30/32 ,  G01N30/6052 ,  G01N30/7233 ,  G01N2030/324

    摘要： A method for making conduits includes inserting an inner tube into an outer tube and melting a portion of the inner tube to form a bond with the outer tube. The inner tube includes a polymeric material and the outer tube includes a material having a greater yield strength than the polymeric material. A conduit includes one or more inner tubes at least one of which is melt-bonded to one or more outer tubes. An analytical instrument includes a separation column, a solvent reservoir and pump, a sample injector, a detector to observe an eluent of the separation column, and tubing to transport fluid between components of the instrument.

    摘要翻译： 制造管道的方法包括将内管插入外管并熔化内管的一部分以与外管形成结合。 内管包括聚合物材料，外管包括具有比聚合材料更高的屈服强度的材料。 导管包括一个或多个内管，其中至少一个内管与一个或多个外管熔融粘合。 分析仪器包括分离柱，溶剂储存器和泵，样品注射器，用于观察分离柱的洗脱液的检测器和用于在仪器的组件之间输送流体的管道。

    In-line process for generating comonomer
    8.
    发明申请
    In-line process for generating comonomer 失效
    产生共聚单体的在线方法

    公开(公告)号：US20070185364A1

    公开(公告)日：2007-08-09

    申请号：US11346651

    申请日：2006-02-03

    申请人： John Buchanan ,  Timothy Shaffer

    发明人： John Buchanan ,  Timothy Shaffer

    IPC分类号： C07C2/02

    CPC分类号： C07C2/26 ,  C08F10/02 ,  C08F210/16 ,  Y02P20/52 ,  C08F2/00

    摘要： The present invention relates to an in-line method for generating comonomer, such as 1-hexene or 1-octene, from monomer, such as ethylene. The comonomer generated is directly transported, without isolation or storage, to a polyethylene polymerization reactor. The in-line method for generating comonomer includes the steps of providing an in-line comonomer synthesis reactor and a downstream gas/liquid phase separator prior to a polyethylene polymerization reactor; feeding ethylene monomer and a catalyst in a solvent to the comonomer synthesis reactor; reacting the ethylene monomer and the catalyst in solvent under reaction conditions to produce an effluent stream including ethylene monomer and comonomer; passing the effluent stream from the comonomer synthesis reactor to the downstream gas/liquid phase separator to separate a gas stream from a bottom stream, wherein the gas stream is a mixture of ethylene monomer, and comonomer; and passing the gas stream to the polyethylene polymerization reactor to provide the necessary comonomer input. The in-line method is useful in the production of LLDPE, and other branched polyethylene based polymers. Some benefits include process simplification and reduced capital and operating costs.

    摘要翻译： 本发明涉及从单体如乙烯生成共聚单体如1-己烯或1-辛烯的直列方法。 生成的共聚单体直接输送到聚乙烯聚合反应器中，无需隔离或储存。 用于生成共聚单体的在线方法包括在聚乙烯聚合反应器之前提供在线共聚单体合成反应器和下游气/液相分离器的步骤; 将乙烯单体和催化剂在溶剂中加入到共聚单体合成反应器中; 在反应条件下使乙烯单体和催化剂在溶剂中反应，以产生包括乙烯单体和共聚单体的流出物流; 将来自共聚单体合成反应器的流出物流输送到下游气/液相分离器以从底部流分离气流，其中气流是乙烯单体和共聚单体的混合物; 并将气流送入聚乙烯聚合反应器以提供所需的共聚单体输入。 在线方法可用于生产LLDPE和其他支化聚乙烯基聚合物。 一些好处包括流程简化，降低资本和运营成本。