公开(公告)号：US06828649B2

公开(公告)日：2004-12-07

申请号：US10140616

申请日：2002-05-07

申请人： John C. Desko ,  Thomas J. Krutsick ,  Chung-Ming Hsieh ,  Brian E. Thompson ,  Bailey Jones ,  Steve Wallace

发明人： John C. Desko ,  Thomas J. Krutsick ,  Chung-Ming Hsieh ,  Brian E. Thompson ,  Bailey Jones ,  Steve Wallace

IPC分类号： H01L2900

CPC分类号： H01L21/763 ,  H01L21/743 ,  H01L23/522 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present invention provides a semiconductor device, a method of manufacture therefor, and an integrated circuit including the same. In one advantageous embodiment, the semiconductor device includes a doped layer located over a semiconductor substrate, and an isolation trench located in the doped layer and having a dielectric layer located on a sidewall thereof. The semiconductor device may further include a conductive material located within the isolation trench and an interconnect that electrically connects the conductive material and the doped layer.

摘要翻译： 本发明提供一种半导体器件及其制造方法以及包括该半导体器件的集成电路。 在一个有利的实施例中，半导体器件包括位于半导体衬底上的掺杂层和位于掺杂层中并且位于其侧壁上的介电层的隔离沟槽。 半导体器件还可以包括位于隔离沟槽内的导电材料和电连接导电材料和掺杂层的互连。

公开(公告)号：US06737311B2

公开(公告)日：2004-05-18

申请号：US09964041

申请日：2001-09-26

申请人： John Desko ,  Chung-Ming Hsieh ,  Bailey Jones ,  Thomas J. Krutsick ,  Brian Thompson ,  Steve Wallace

发明人： John Desko ,  Chung-Ming Hsieh ,  Bailey Jones ,  Thomas J. Krutsick ,  Brian Thompson ,  Steve Wallace

IPC分类号： H01L2972

CPC分类号： H01L27/0921 ,  H01L21/823878 ,  H01L21/823892

摘要： The present invention provides a semiconductor device, a method of manufacture therefor, and an integrated circuit including the semiconductor device. The semiconductor device may include a well doped with a P-type dopant located over a semiconductor substrate. The semiconductor device may further include a buried layer including the P-type dopant located between the well and the semiconductor substrate, and a gate located over the well.

摘要翻译： 本发明提供一种半导体器件及其制造方法以及包括半导体器件的集成电路。 半导体器件可以包括掺杂有位于半导体衬底上的P型掺杂剂的阱。 半导体器件还可以包括掩埋层，其包括位于阱和半导体衬底之间的P型掺杂剂，以及位于阱上方的栅极。

公开(公告)号：US06690037B1

公开(公告)日：2004-02-10

申请号：US09653616

申请日：2000-08-31

申请人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

发明人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

IPC分类号： H01L2974

CPC分类号： H01L29/402 ,  H01L29/872

摘要： A Schottky diode is fabricated by a sequence of fabrication by a sequence of fabrication steps. An active region of a semiconductor substrate is defined in which a Schottky diode is fabricated. At least first and second layers of insulating material are applied over the active area. A first layer of insulating material, having a first etching rate, is applied over the active area. A second layer of insulating material having a second, greater, etch rate is applied over the first layer of insulating material to a thickness that is about twice the thickness of the first layer of insulating material. The insulating material is patterned and a window is etched through the layers of insulating material to the semiconductor substrate. Metal is applied and unwanted metal is etched away leaving metal in the window forming a Schottky contact therein. One or more barrier layers may be employed.

摘要翻译： 通过一系列制造步骤制造肖特基二极管。 定义半导体衬底的有源区，其中制造肖特基二极管。 至少第一和第二层绝缘材料施加在有效区域上。 在有源区域上施加具有第一蚀刻速率的第一绝缘材料层。 具有第二，更大蚀刻速率的第二层绝缘材料施加在绝缘材料的第一层上，其厚度约为第一绝缘材料层厚度的两倍。 对绝缘材料进行图案化，并且通过绝缘材料层蚀刻窗口到半导体衬底。 金属被施加并且不需要的金属被蚀刻掉，留下窗口中的金属在其中形成肖特基接触。 可以采用一个或多个阻挡层。

公开(公告)号：US06790753B2

公开(公告)日：2004-09-14

申请号：US10696136

申请日：2003-10-29

申请人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

发明人： John Charles Desko ,  Michael J Evans ,  Chung-Ming Hsieh ,  Tzu-Yen Hsieh ,  Bailey R Jones ,  Thomas J. Krutsick ,  John Michael Siket, Jr. ,  Brian Eric Thompson ,  Steven W. Wallace

IPC分类号： H01L2128

CPC分类号： H01L29/402 ,  H01L29/872

摘要： A Schottky diode is fabricated by a sequence of fabrication by a sequence of fabrication steps. An active region of a semiconductor substrate is defined in which a Schottky diode is fabricated. At least first and second layers of insulating material are applied over the active area. A first layer of insulating material, having a first etching rate, is applied over the active area. A second layer of insulating material having a second, greater, etch rate is applied over the first layer of insulating material to a thickness that is about twice the thickness of the first layer of insulating material. The insulating material is patterned and a window is etched through the layers of insulating material to the semiconductor substrate. Metal is applied and unwanted metal is etched away leaving metal in the window forming a Schottky contact therein. One or more barrier layers may be employed.

公开(公告)号：US08916504B2

公开(公告)日：2014-12-23

申请号：US12570931

申请日：2009-09-30

申请人： Chung-Ming Hsieh ,  Yuliya A. Kutskova ,  John E. Memmott

发明人： Chung-Ming Hsieh ,  Yuliya A. Kutskova ,  John E. Memmott

IPC分类号： C40B30/04 ,  C07K17/00

CPC分类号： G01N33/54326 ,  C12N15/1041

摘要： The present invention features improved methods of in vitro RNA display to allow reliable expression and selection of scFv antibody molecules from expression libraries. The improved methods, in part, involve the use of mildly reducing conditions, which favor of scFv intra-chain disulphide bond and thus correct folding of the scFv antibody molecules. Although particularly suited to expression and selection of scFv antibody molecules, the methods of the invention are also expedient for in vitro RNA display of all classes of protein.

摘要翻译： 本发明的特征在于体外RNA显示的改进方法，以允许来自表达文库的scFv抗体分子的可靠表达和选择。 改进的方法部分地涉及使用轻度还原条件，其有利于scFv链内二硫键，从而正确折叠scFv抗体分子。 尽管特别适合于scFv抗体分子的表达和选择，本发明的方法也适用于所有类别的蛋白质的体外RNA显示。

公开(公告)号：US20140348856A1

公开(公告)日：2014-11-27

申请号：US14262653

申请日：2014-04-25

申请人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

发明人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Anwar Murtaza ,  Bradford L. McRae ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers ,  Craig Wallace ,  Shaughn H. Bryant ,  Mary R. Leddy

IPC分类号： C07K16/24

CPC分类号： C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

摘要翻译： 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：US08835610B2

公开(公告)日：2014-09-16

申请号：US12718841

申请日：2010-03-05

申请人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers

发明人： Chung-Ming Hsieh ,  Margaret Hugunin ,  Yuliya Kutskova ,  John E. Memmott ,  Jennifer M. Perez ,  Suju Zhong ,  Edit Tarcsa ,  Anca Clabbers

IPC分类号： A61K39/395 ,  C07K16/24

CPC分类号： C07K16/468 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/507 ,  A61K2300/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/565 ,  C07K2317/64 ,  C07K2317/76 ,  C07K2317/92 ,  Y02A50/386 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/466

摘要： Proteins that bind IL-17 and/or IL-17F are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

摘要翻译： 描述了结合IL-17和/或IL-17F的蛋白质及其在用于治疗，预防和诊断IL-17相关疾病和用于检测细胞，组织，样品和组合物中的IL-17的组合物和方法中的用途。

公开(公告)号：US20110217237A1

公开(公告)日：2011-09-08

申请号：US13037932

申请日：2011-03-01

申请人： Ming-Jiu Chen ,  Chung-Ming Hsieh ,  Jijie Gu ,  Susan E. Morgan-Lappe ,  Yingchun Li

发明人： Ming-Jiu Chen ,  Chung-Ming Hsieh ,  Jijie Gu ,  Susan E. Morgan-Lappe ,  Yingchun Li

IPC分类号： A61K49/00 ,  C07K16/00 ,  C07K17/00 ,  C07H21/00 ,  A61K39/395 ,  A61P35/00 ,  A61P43/00 ,  A61P9/00 ,  A61P25/28 ,  A61P17/06 ,  C12N9/96 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10 ,  C12N1/15 ,  C12N1/19 ,  C12N1/00 ,  C12P21/00

CPC分类号： C07K16/28 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.

摘要翻译： 本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体及其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。

公开(公告)号：US20110117079A1

公开(公告)日：2011-05-19

申请号：US12870276

申请日：2010-08-27

申请人： Lorenzo Benatuil ,  Erwin R. Boghaert ,  Jijie Gu ,  Maria Harris ,  Jonathan A. Hickson ,  Chung-Ming Hsieh ,  Yuliya Kutskova ,  Yingchun Li ,  Zhihong Liu ,  Susan Morgan-Lappe

发明人： Lorenzo Benatuil ,  Erwin R. Boghaert ,  Jijie Gu ,  Maria Harris ,  Jonathan A. Hickson ,  Chung-Ming Hsieh ,  Yuliya Kutskova ,  Yingchun Li ,  Zhihong Liu ,  Susan Morgan-Lappe

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N9/96 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10 ,  C12N1/19 ,  C12P21/00 ,  A61P35/00 ,  A61P13/08 ,  A61P9/10 ,  A61P17/02 ,  A61P35/04

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.

摘要翻译： 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管发生依赖性疾病，例如眼新生血管形成或以异常DLL4表达或活性为特征的血管发生非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。

公开(公告)号：US20100099103A1

公开(公告)日：2010-04-22

申请号：US12570897

申请日：2009-09-30

申请人： Chung-Ming Hsieh ,  Yuliya A. Kutskova ,  John E. Memmott

发明人： Chung-Ming Hsieh ,  Yuliya A. Kutskova ,  John E. Memmott

IPC分类号： C12Q1/68 ,  C07H21/00 ,  C40B40/08 ,  C40B50/06

CPC分类号： C40B50/06 ,  C07K16/00 ,  C07K16/1018 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/21 ,  C07K2317/622 ,  C12Q2563/185 ,  C40B40/08

摘要： The present invention features improved in vitro RNA display libraries to allow reliable expression and selection of scFv antibody molecules from expression libraries. The scFv antibody libraries of the invention contain an optimized, shortened inter-domain linker that improves expression scFv antibody expression. The scFv antibody libraries also include short nucleic acid barcodes that allow for identification of individual library clones, libraries or subsets thereof. Primers for generating, amplifying and spectratyping the scFv antibody libraries of the invention are also provided.

摘要翻译： 本发明的特征在于改进的体外RNA显示文库以允许来自表达文库的scFv抗体分子的可靠表达和选择。 本发明的scFv抗体文库含有改善表达scFv抗体表达的优化的缩短的域间连接体。 scFv抗体文库还包括允许识别单个文库克隆，文库或其子集的短核酸条形码。 还提供了用于产生，扩增和分光本发明的scFv抗体文库的引物。