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1.Substituted thieno[2,3-B]furan-2-sulfonamides as antiglaucoma agents 失效
标题翻译: 取代的噻吩并[2,3-B]呋喃-2-磺酰胺作为抗青光眼剂公开(公告)号:US4798831A
公开(公告)日:1989-01-17
申请号:US190183
申请日:1988-05-04
IPC分类号: C07D495/04 , A61K31/38 , C07D403/00 , C07D421/00 , C07D495/02
CPC分类号: C07D495/04
摘要: Thieno[2,3-b]furan-2-sulfonamides are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure and glaucoma.
摘要翻译: 噻吩并[2,3-b]呋喃-2-磺酰胺是可用于治疗眼内压升高和青光眼的碳酸酐酶抑制剂。
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公开(公告)号:US5397791A
公开(公告)日:1995-03-14
申请号:US103846
申请日:1993-08-09
IPC分类号: A61K31/38 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , A61K45/06 , A61P7/02 , C07D487/04 , C07D491/04 , C07D491/048 , C07D493/04 , C07D495/04 , C07D497/04 , C07D498/04 , C07D513/04 , C07D401/10 , C07D409/06 , C07D411/06
CPC分类号: C07D487/04 , A61K45/06 , C07D491/04 , C07D493/04 , C07D495/04 , C07D497/04 , C07D513/04
摘要: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
摘要翻译: 具有式
I的纤维蛋白原受体拮抗剂例如 -
公开(公告)号:US5334596A
公开(公告)日:1994-08-02
申请号:US62510
申请日:1993-05-11
IPC分类号: C07D487/02 , A61K31/40 , A61K31/41 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/53 , A61P7/02 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号: C07D495/04
摘要: Fibrinogen receptor antagonists having the formula ##STR1## for example ##STR2##
摘要翻译: 具有式
的纤维蛋白原受体拮抗剂例如 -
公开(公告)号:USRE36520E
公开(公告)日:2000-01-18
申请号:US188155
申请日:1998-11-04
申请人: Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker , Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta Jyh Lee
发明人: Robert L. Smith , Wasyl Halczenko , George D. Hartman , Gerald E. Stokker , Edward S. Inamine , Otto D. Hensens , David R. Houck , Ta Jyh Lee
IPC分类号: C07C69/732 , C07D309/30 , C12P7/62 , C12P17/06 , A61K31/225 , C07C69/74
CPC分类号: C07C69/732 , C07D309/30 , C12P17/06 , C12P7/62 , C12R1/365
摘要: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##
摘要翻译: 新型3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂可用作抗高胆固醇血症药,并由以下通式(II)表示:
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公开(公告)号:US5880136A
公开(公告)日:1999-03-09
申请号:US130334
申请日:1998-08-06
申请人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
发明人: Mark E. Duggan , Melissa S. Egbertson , Wasyl Halczenko , George D. Hartman , William L. Laswell
IPC分类号: C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40
CPC分类号: C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要: A series of non-peptide derivatives that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
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公开(公告)号:US5227490A
公开(公告)日:1993-07-13
申请号:US838950
申请日:1992-02-21
申请人: George D. Hartman , Wasyl Halczenko
发明人: George D. Hartman , Wasyl Halczenko
IPC分类号: C07D211/22
CPC分类号: C07D211/22
摘要: Novel fibrinogen receptor antagonists of the formula ##STR1## are provided in which the claimed compounds exhibit fibrinogen receptor antagonist activity, inhibit platelet aggregation and are therefore useful in modulating thrombus formation.
摘要翻译: 提供式(I)的新型纤维蛋白原受体拮抗剂,其中所要求保护的化合物显示纤维蛋白原受体拮抗剂活性,抑制血小板聚集,因此可用于调节血栓形成。
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公开(公告)号:US06784190B2
公开(公告)日:2004-08-31
申请号:US09916977
申请日:2001-07-27
申请人: Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
发明人: Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
IPC分类号: A61K3147
CPC分类号: C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04
摘要: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3, &agr;v&bgr;5, and/or &agr;v&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译: 本发明涉及其化合物及其衍生物,其合成及其作为整联蛋白受体拮抗剂的用途。 更具体地说,本发明的化合物是整联蛋白受体alphavbeta3,alphavbeta5和/或alphavbeta6的拮抗剂,可用于抑制骨吸收,治疗和预防骨质疏松,抑制血管再狭窄,糖尿病性视网膜病变,黄斑变性,血管生成,动脉粥样硬化 ,炎症,伤口愈合,病毒性疾病,肿瘤生长和转移。
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公开(公告)号:US6048861A
公开(公告)日:2000-04-11
申请号:US212082
申请日:1998-12-15
申请人: Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
发明人: Ben C. Askew , Paul J. Coleman , Mark E. Duggan , Wasyl Halczenko , George D. Hartman , Cecilia A. Hunt , John H. Hutchinson , Robert S. Meissner , Michael A. Patane , Garry R. Smith , Jiabing Wang
IPC分类号: C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04 , C07D519/00 , A61K31/435 , A61K31/44
CPC分类号: C07D401/06 , C07D401/12 , C07D471/04 , C07D495/04
摘要: The present invention relates to compounds and derivatives thereof, their synthesis, and their use as integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors .alpha.v.beta.3, .alpha.v.beta.5, and/or .alpha.v.beta.6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
摘要翻译: 本发明涉及其化合物及其衍生物,其合成及其作为整联蛋白受体拮抗剂的用途。 更具体地说,本发明的化合物是整联蛋白受体αvβ3,αvβ5和/或αvβ6的拮抗剂,可用于抑制骨吸收,治疗和预防骨质疏松症,并抑制血管再狭窄, 糖尿病性视网膜病变,黄斑变性,血管生成,动脉粥样硬化,炎症,伤口愈合,病毒性疾病,肿瘤生长和转移。
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公开(公告)号:US5292756A
公开(公告)日:1994-03-08
申请号:US860747
申请日:1992-03-25
IPC分类号: C07D211/30 , A61K31/185 , A61K31/195 , A61K31/215 , A61K31/255 , A61K31/265 , A61K31/40 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/435 , A61K31/44 , A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4465 , A61K31/451 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/55 , A61K31/66 , A61P7/02 , A61P43/00 , C07C311/02 , C07C311/06 , C07C311/13 , C07C311/19 , C07C313/06 , C07C313/20 , C07C323/59 , C07C327/12 , C07D207/08 , C07D207/09 , C07D207/10 , C07D207/12 , C07D207/26 , C07D207/273 , C07D209/12 , C07D209/30 , C07D211/18 , C07D211/22 , C07D211/32 , C07D211/46 , C07D213/75 , C07D223/08 , C07D233/02 , C07D233/64 , C07D237/08 , C07D239/04 , C07D239/26 , C07D241/04 , C07D241/12 , C07D249/04 , C07D249/08 , C07D263/46 , C07D267/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D413/14 , C07D453/02 , C07D453/06 , C07D471/08 , C07D487/08 , C07F9/38 , C07F9/40 , C07D267/22
CPC分类号: C07C311/06 , C07C311/13 , C07D211/22 , C07D409/12
摘要: A series of non-peptide derivatives of the formula ##STR1## that are antagonists of the fibrinogen IIb/IIIa receptor and thus are platelet anti-aggregation compounds useful in the prevention and treatment of diseases caused by thrombus formation.
摘要翻译: 一系列式(IMAGE)的非肽衍生物
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公开(公告)号:US4847289A
公开(公告)日:1989-07-11
申请号:US59084
申请日:1987-06-08
申请人: John J. Baldwin , Charles M. Habecker , Samuel L. Graham , Wasyl Halczenko , George D. Hartman , Harvey Schwam , Gerald S. Ponticello , Kenneth L. Shepard
发明人: John J. Baldwin , Charles M. Habecker , Samuel L. Graham , Wasyl Halczenko , George D. Hartman , Harvey Schwam , Gerald S. Ponticello , Kenneth L. Shepard
IPC分类号: A61K31/38 , A61K31/381 , A61P9/12 , A61P27/02 , A61P27/06 , C07D333/34 , C07D409/12
CPC分类号: C07D409/12 , C07D333/34
摘要: Aryl (or aralkyl)-sulfonylthiophene-2-sulfonamides containing a basic functional group as a substituent are efficacious in the treatment of elevated intraocular pressure and glaucoma following topical ocular administration.
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