公开(公告)号：US06702834B1

公开(公告)日：2004-03-09

申请号：US09727102

申请日：2000-11-28

申请人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

发明人： John F. Boylan ,  William J. Boyle ,  Andy E. Denison ,  Debashis Dutta ,  Benjamin C. Huter ,  Scott J. Huter ,  Paul F. Muller ,  Samir Patel ,  Christopher J. Tarapata ,  Chicheng Wang ,  Francisco Sanchez ,  Kent C. B. Stalker

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guide wire and is deployed within the patient's vasculature as the guide wire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guide wire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导丝被操纵进入治疗区域时，其被布置在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US06695813B1

公开(公告)日：2004-02-24

申请号：US09476159

申请日：1999-12-30

申请人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

发明人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

IPC分类号： A61M2900

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device includes a filtering assembly having a self-expanding strut assembly and a filter element. The filtering assembly can be attached to a guidewire and deployed within the patient's vasculature into an area of treatment. A restraining sheath maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Interventional devices can be delivered over the guidewire and any embolic debris created and released into the blood stream will enter the filtering assembly. The filtering assembly can be rotatably mounted on the guide wire and may include a dampening element which helps to prevent some shock force that may be transmitted along the guide to the deployed filtering assembly.

摘要翻译： 栓塞保护装置包括具有自扩张支柱组件和过滤元件的过滤组件。 过滤组件可以附接到导丝并且部署在患者的脉管系统内进入治疗区域。 限制护套将过滤组件保持在其折叠位置，直到其准备好被医生部署为止。 介入装置可以通过导线传送，并且产生并释放到血流中的任何栓塞碎片将进入过滤组件。 过滤组件可以可旋转地安装在导丝上，并且可以包括阻尼元件，该阻尼元件有助于防止可能沿着引导件传递到部署的过滤组件的一些冲击力。

公开(公告)号：US08845583B2

公开(公告)日：2014-09-30

申请号：US11651667

申请日：2007-01-10

申请人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

发明人： William J. Boyle ,  David H. Burkett ,  Andy E. Denison ,  Benjamin C. Huter ,  Scott J. Huter ,  Arkady Kokish ,  Kent C. B. Stalker ,  Chicheng Wang ,  John D. Whitfield

IPC分类号： A61M29/00 ,  A61F2/01

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US06506202B1

公开(公告)日：2003-01-14

申请号：US09612855

申请日：2000-07-10

申请人： Debashis Dutta ,  Chicheng Wang

发明人： Debashis Dutta ,  Chicheng Wang

IPC分类号： A61M2900

CPC分类号： A61F2/958 ,  A61F2002/9583 ,  A61M25/10 ,  A61M2025/1075

摘要： A system used in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region, which is capable of treating an entire affected area in a blood vessel while preventing adverse effects for healthy tissue. The system includes a catheter which is positionable in a blood vessel at the interventional procedure site. The system further includes an expandable interventional instrument such as an expandable stent which is expandable and which may be deployed in the blood vessel at the interventional procedure site, which includes an unexpanded axial dimension. The system also includes an expandable member such as an expandable balloon, for expanding the expandable stent. The expandable balloon is capable of expanding so as to expand and deploy the expandable stent, and to substantially retain the unexpanded axial dimension of the expandable stent. The expansion of the expandable balloon prevents lengthening or shortening of the expandable stent, so as to enable the entire affected lesion area to be covered precisely without affecting the surrounding healthy tissue upon deployment of the expandable stent.

摘要翻译： 当在狭窄或闭塞的区域进行介入手术时在血管中使用的系统，其能够治疗血管中的整个受影响区域，同时防止对健康组织的不利影响。 该系统包括可在介入手术部位的血管中定位的导管。 该系统还包括可扩张的介入器械，例如可扩张的支架，其是可扩张的并且可以在包括未膨胀的轴向尺寸的介入手术部位的血管中展开。 该系统还包括可膨胀构件，例如可膨胀气囊，用于扩张可扩张支架。 可膨胀气囊能够膨胀以扩张和展开可扩张支架，并且基本上保持可扩张支架的未膨胀的轴向尺寸。 可膨胀气囊的膨胀防止了可扩张支架的延长或缩短，从而使整个受影响的损伤区域能够精确地覆盖，而不会在展开支架时展开周围的健康组织。

公开(公告)号：US06702849B1

公开(公告)日：2004-03-09

申请号：US09460271

申请日：1999-12-13

申请人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

发明人： Debashis Dutta ,  Chicheng Wang ,  Kondapavulur T. V. Rao

IPC分类号： A61F206

CPC分类号： A61L31/16 ,  A61F2002/072 ,  A61L27/40 ,  A61L27/54 ,  A61L27/56 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/602 ,  A61L2300/606 ,  C08L67/04

摘要： Porous vascular grafts and stent covers are formed of open-celled microcellular polymeric foams having a porosity that can be modified to be adapted for carrying and delivering different types of therapeutic drugs. A stent cover is formed of a tubular member including at least one layer of a porous, microcellular foam formed from a polymeric material capable of absorbing and releasing therapeutic drugs at predictable rates for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. A composite metal and polymer vascular graft is formed of an interior structural stent member, and an outer layer or coating of the porous, microcellular foam. The method of making the composite metal and polymer vascular graft involves providing an interior structural stent member with an outer layer or coating of the porous, microcellular foam, and can further comprise the step of loading a therapeutic drug into the outer layer of the porous, microcellular foam for delivery of the therapeutic drugs in localized drug therapy in a blood vessel.

摘要翻译： 多孔血管移植物和支架覆盖物由具有孔隙率的开孔微孔聚合物泡沫形成，孔隙度可以被修饰以适于携带和递送不同类型的治疗药物。 支架盖由管状构件形成，该管状构件包括由能够以可预测的速率吸收和释放治疗药物的聚合材料形成的多孔微孔泡沫层，用于在血管中的局部药物治疗中递送治疗药物。 复合金属和聚合物血管移植物由内部结构支架构件和多孔微孔泡沫的外层或涂层形成。 制备复合金属和聚合物血管移植物的方法包括提供具有多孔，微孔泡沫体的外层或涂层的内部结构支架构件，并且还可以包括将治疗药物装载到多孔， 用于在血管中局部药物治疗中递送治疗药物的微孔泡沫。

公开(公告)号：US06290722B1

公开(公告)日：2001-09-18

申请号：US09523635

申请日：2000-03-13

申请人： Chicheng Wang

发明人： Chicheng Wang

IPC分类号： A61F204

CPC分类号： A61F2/92 ,  A61F2210/0076 ,  A61F2250/0067

摘要： The present invention includes a stent. The stent comprises a structural support and a polymeric film or sheet or tube that overlays the structural support. The stent also includes a tacky portion that adheres the polymeric film or sheet or tube to the structural support. The tacky portion comprises sugar or starch or polyvinylalcohol or degradation products of these materials.

摘要翻译： 本发明包括支架。 支架包括结构支撑件和覆盖结构支撑件的聚合物膜或片或管。 支架还包括将聚合物膜或片或管粘合到结构支撑件上的粘性部分。 粘性部分包括糖或淀粉或聚乙烯醇或这些材料的降解产物。

公开(公告)号：US06800089B1

公开(公告)日：2004-10-05

申请号：US09583263

申请日：2000-05-31

申请人： Chicheng Wang

发明人： Chicheng Wang

IPC分类号： A61F206

CPC分类号： A61F2/07 ,  A61F2/915 ,  A61F2002/075

摘要： The present invention relates to a stent comprising a structural support and a polymeric film or sheet or tube. The structural support comprises an outer surface that is roughened patterned. The polymeric film or sheet or tube is retained to the structural support by the roughened or patterned outer surface of the structural support.

摘要翻译： 本发明涉及包括结构支架和聚合物膜或片或管的支架。 结构支撑件包括粗糙化或图案化的外表面。 聚合物膜或片或管通过结构支撑体的粗糙化或图案化外表面保持在结构支撑体上。

公开(公告)号：US06761732B2

公开(公告)日：2004-07-13

申请号：US10259920

申请日：2002-09-27

申请人： David H. Burkett ,  Arkady Kokish ,  Chicheng Wang

发明人： David H. Burkett ,  Arkady Kokish ,  Chicheng Wang

IPC分类号： A61F206

CPC分类号： A61F2/958 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/008

摘要： A catheter apparatus includes a lesion dilating member disposable at a lesion position in a vessel (e.g. a patient's artery) which is dilatable to open the vessel at the lesion position. An emboli-capturing assembly having a perfusion member and filter is displaced downstream from the lesion dilating member to capture embolic debris released in the fluid flow. The perfusion member may illustratively have peaks and channels formed between adjacent peaks which cooperate with the filter to create trapping pockets that capture embolic debris. The filter may be made from any flexible and porous material with dimensions to pass the fluid and block the emboli. The perfusion member is thereafter deflated to provide for emboli retention in the perfusion member.

摘要翻译： 导管装置包括在容器（例如患者的动脉）中的损伤位置处一次性的病变扩张构件，其可扩张以在病变位置打开血管。 具有灌注构件和过滤器的栓塞捕获组件从病变扩张构件的下游位移，以捕获在流体流中释放的栓塞碎片。 灌注构件可以示例性地具有在相邻峰之间形成的峰和通道，其与过滤器配合以产生捕获栓塞碎片的捕集袋。 过滤器可以由具有尺寸的任何柔性和多孔材料制成以通过流体并阻塞栓塞。 然后灌注构件放气以提供灌注构件中的栓塞保留。

公开(公告)号：US20070167975A1

公开(公告)日：2007-07-19

申请号：US11651667

申请日：2007-01-10

申请人： William Boyle ,  David Burkett ,  Andy Denison ,  Benjamin Huter ,  Scott Huter ,  Arkady Kokish ,  Kent Stalker ,  Chicheng Wang ,  John Whitfield

发明人： William Boyle ,  David Burkett ,  Andy Denison ,  Benjamin Huter ,  Scott Huter ,  Arkady Kokish ,  Kent Stalker ,  Chicheng Wang ,  John Whitfield

IPC分类号： A61M29/00

CPC分类号： A61F2/013 ,  A61F2002/011 ,  A61F2002/015 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/005 ,  A61F2230/0067 ,  A61F2230/008

摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.

摘要翻译： 一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。 该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。 在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。 以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。 此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。 介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。 其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

公开(公告)号：US06719774B1

公开(公告)日：2004-04-13

申请号：US09471199

申请日：1999-12-23

申请人： Chicheng Wang

发明人： Chicheng Wang

IPC分类号： A61M2900

CPC分类号： A61M25/1029 ,  A61M25/10

摘要： Methods for forming low profile balloons for use with a catheter by providing a polymeric tube, removing material from the outer surface of the polymeric tube around at least one of its end portions, and inflating a region of the polymeric tube between the two end portions to form the balloon. Low profile balloons having end portions with an outer diameter below 30 mils are also disclosed.

摘要翻译： 用于通过提供聚合物管形成用于导管的低轮廓气囊的方法，从聚合物管的外表面围绕其至少一个端部移除材料，以及将聚合物管的两个端部之间的区域充气至 形成气球 还公开了具有外径低于30密耳的端部的低轮廓气囊。