-
1.发明申请COMPOSITIONS CONTAINING LYSOPHOSPHATIDIC ACIDS WHICH INHIBIT APOPTOSIS AND USES THEREOF 审中-公开含有抑制性卵巢囊虫病的组合物及其用途公开(公告)号：US20080076736A1
公开(公告)日：2008-03-27
申请号：US11834505
申请日：2007-08-06
申请人： John Goddard , Donald Picker , Samuil Umansky , Steven Price , Jac Wijkmans , Edward Boyd , Anthony Baxter
发明人： John Goddard , Donald Picker , Samuil Umansky , Steven Price , Jac Wijkmans , Edward Boyd , Anthony Baxter
CPC分类号： C07F9/091
摘要： The invention provides anti-apoptotic compositions containing lysophosphatidic acids and methods for making and using the compositions. Such compositions may also contain LPA potentiating agents, including proteins, lipid membrane structures and polymers such as polyethylene glycols. The compositions can additionally contain other pharmaceutically effective agents such as drugs, antibiotics, wound healing agents and antioxidants.
摘要翻译： 本发明提供含有溶血磷脂酸的抗凋亡组合物和制备和使用组合物的方法。 此类组合物还可含有LPA增效剂，包括蛋白质，脂质膜结构和聚合物如聚乙二醇。 组合物可另外含有其它药学上有效的试剂，例如药物，抗生素，伤口愈合剂和抗氧化剂。
-
公开(公告)号：US20120233787A1
公开(公告)日：2012-09-20
申请号：US13419421
申请日：2012-03-13
申请人： Wally Couto , John Goddard
发明人： Wally Couto , John Goddard
IPC分类号： A61G3/06
摘要： A vehicle ramp system has multiple configurations. The simplest embodiment provides a ramp which can move between a retracted configuration and an extended “step in” configuration in which an outboard end of the ramp is closer to the ground than in the retracted configuration, so that the outboard end of the ramp functions as a lowered step. A preferred embodiment provides a fully retracted configuration, a partially extended “step in” configuration, a partially extended “curb ramp” configuration in which the outboard end of the ramp can engage a curb or sidewalk, and a fully extended configuration in which the outboard end of the ramp can engage a road surface of the road on which the vehicle carrying the ramp is supported.
摘要翻译： 车辆坡道系统具有多种配置。 最简单的实施例提供了斜坡，其可以在缩回配置和延伸的“阶梯”“配置之间移动，其中斜坡的外侧端比在缩回配置中更靠近地面，使得斜坡的外侧端作为 降低了一步。 优选实施例提供了完全缩回的构造，部分延伸的“台阶”构造，部分延伸的“路缘坡道”构造，其中坡道的外侧端可以接合路缘石或人行道，以及完全延伸的构造，其中外侧 斜坡的端部可以接合支撑有斜坡的车辆的道路的路面。
-
公开(公告)号：US4884736A
公开(公告)日：1989-12-05
申请号：US307055
申请日：1989-02-07
申请人： John Goddard
发明人： John Goddard
CPC分类号： B23K20/1205 , F01D5/3061 , B23K2201/001 , Y10T74/182
摘要： A mechanism suitable for friction welding aerofoil blades to the periphery of a disc. The mechanism comprises a first member (flywheel 12) which has an ecentric crank pin. Two pivotally interconnected links 18 and 20 are connected between the crank pin and a second member 19 which is pivotally mounted. A blade to be friction welded (by rubbing it in an arcuate path on the disc) is mounted at the point of pivotal connection 32 between the second link 20 and the member 19. An actuator lever 24 is pivotally mounted on a pivot 22 which is located in the vicinity of the locus of movement of the pivotal interconnection 30 between the two links 18, 20. The actuator has a third link 28 which is of the same length as the link 20. The third link is connected by a pivot 26 to the lever 24 at a radius equal to the length of the second and third links 20 and 28. Movement of the lever 24 about its pivot 22 when the pivots 30 and 22 coincide, to bring the pivot 26 into line with the pivot 32 freezes the oscillation of the pivot 32 to enable the blade to be welded to the disc at a precise location along the arcuate path.
-
公开(公告)号：US08800087B2
公开(公告)日：2014-08-12
申请号：US14025785
申请日：2013-09-12
申请人： Wally Couto , John Goddard
发明人： Wally Couto , John Goddard
摘要： A vehicle ramp system has multiple configurations. The simplest embodiment provides a ramp which can move between a retracted configuration and an extended “step in” configuration in which an outboard end of the ramp is closer to the ground than in the retracted configuration, so that the outboard end of the ramp functions as a lowered step. A preferred embodiment provides a fully retracted configuration, a partially extended “step in” configuration, a partially extended “curb ramp” configuration in which the outboard end of the ramp can engage a curb or sidewalk, and a fully extended configuration in which the outboard end of the ramp can engage a road surface of the road on which the vehicle carrying the ramp is supported.
摘要翻译： 车辆坡道系统具有多种配置。 最简单的实施例提供了斜坡，其可以在缩回配置和延伸的“阶梯”“配置之间移动，其中斜坡的外侧端比在缩回配置中更靠近地面，使得斜坡的外侧端作为 降低了一步。 优选实施例提供了完全缩回的构造，部分延伸的“台阶”构造，部分延伸的“路缘坡道”构造，其中坡道的外侧端可以接合路缘石或人行道，以及完全延伸的构造，其中外侧 斜坡的端部可以接合支撑有斜坡的车辆的道路的路面。
-
公开(公告)号：US20140044512A1
公开(公告)日：2014-02-13
申请号：US14025785
申请日：2013-09-12
申请人： Wally Couto , John Goddard
发明人： Wally Couto , John Goddard
IPC分类号： B60P1/43
摘要： A vehicle ramp system has multiple configurations. The simplest embodiment provides a ramp which can move between a retracted configuration and an extended “step in” configuration in which an outboard end of the ramp is closer to the ground than in the retracted configuration, so that the outboard end of the ramp functions as a lowered step. A preferred embodiment provides a fully retracted configuration, a partially extended “step in” configuration, a partially extended “curb ramp” configuration in which the outboard end of the ramp can engage a curb or sidewalk, and a fully extended configuration in which the outboard end of the ramp can engage a road surface of the road on which the vehicle carrying the ramp is supported.
摘要翻译： 车辆坡道系统具有多种配置。 最简单的实施例提供了斜坡，其可以在缩回配置和延伸的“阶梯”“配置之间移动，其中斜坡的外侧端比在缩回配置中更靠近地面，使得斜坡的外侧端作为 降低了一步。 优选实施例提供了完全缩回的构造，部分延伸的“台阶”构造，部分延伸的“路缘坡道”构造，其中坡道的外侧端可以接合路缘石或人行道，以及完全延伸的构造，其中外侧 斜坡的端部可以接合支撑有斜坡的车辆的道路的路面。
-
公开(公告)号：US08555443B2
公开(公告)日：2013-10-15
申请号：US13419421
申请日：2012-03-13
申请人： Wally Couto , John Goddard
发明人： Wally Couto , John Goddard
IPC分类号： E01D15/127
摘要： A vehicle ramp system has multiple configurations. The simplest embodiment provides a ramp which can move between a retracted configuration and an extended “step in” configuration in which an outboard end of the ramp is closer to the ground than in the retracted configuration, so that the outboard end of the ramp functions as a lowered step. A preferred embodiment provides a fully retracted configuration, a partially extended “step in” configuration, a partially extended “curb ramp” configuration in which the outboard end of the ramp can engage a curb or sidewalk, and a fully extended configuration in which the outboard end of the ramp can engage a road surface of the road on which the vehicle carrying the ramp is supported.
摘要翻译： 车辆坡道系统具有多种配置。 最简单的实施例提供了斜坡，其可以在缩回配置和延伸的“阶梯”“配置之间移动，其中斜坡的外侧端比在缩回配置中更靠近地面，使得斜坡的外侧端作为 降低了一步。 优选实施例提供了完全缩回的构造，部分延伸的“台阶”构造，部分延伸的“路缘坡道”构造，其中坡道的外侧端可以接合路缘石或人行道，以及完全延伸的构造，其中外侧 斜坡的端部可以接合支撑有斜坡的车辆的道路的路面。
-
公开(公告)号：US4678113A
公开(公告)日：1987-07-07
申请号：US827397
申请日：1986-02-10
申请人： Stuart A. Bridges , John Goddard
发明人： Stuart A. Bridges , John Goddard
CPC分类号： A46D3/05 , A46D1/08 , F16J15/3288
摘要： A method of manufacturing a brush seal is disclosed which comprises producing a plurality of tufts of brush material and securing the tufts between two side plates to form a seal. Each tuft is produced by forming a tape which comprises one or more layers of parallel contiguous lengths of filaments adhesively bonded together to form a self supporting body. The tape is cut into discrete portions and these constitute tufts of bonded filaments. A plurality of tufts are assembled closely adjacent to each other in a support member with a part of each tuft projecting from the support member, and the tufts are subsequently secured in the support member. Finally the adhesive is removed from at least that part of each tuft which projects from the support member.
摘要翻译： 公开了一种制造刷式密封件的方法，其包括产生多个刷毛簇并将簇固定在两个侧板之间以形成密封。 通过形成一个带，其包括一层或多层平行连续长度的细丝粘结在一起以形成自支撑体，从而产生每个簇。 将带切割成离散的部分，并且这些构成簇结合的长丝。 多个刷毛簇在支撑构件中彼此紧密相邻地组装，每个簇的一部分从支撑构件突出，并且簇随后被固定在支撑构件中。 最后，粘合剂从至少从支撑构件突出的每个刷毛簇的那部分移除。
-
公开(公告)号：US20100026019A1
公开(公告)日：2010-02-04
申请号：US12576882
申请日：2009-10-09
申请人： Wally Couto , John Goddard
发明人： Wally Couto , John Goddard
CPC分类号： B62D43/10 , B60R19/38 , B60R19/48 , E05B51/02 , E05C3/30 , E05F1/1091 , E05F5/00 , E05Y2201/21 , E05Y2201/264 , E05Y2900/506 , Y10T292/1001
摘要： A bumper mounting assembly comprises a support member mountable to a vehicle front and a bumper-carrying member hingedly mounted to the support member to be movable between an upright position and a lowered position. A primary actuator is secured to the support member and the bumper-carrying member and can apply braking force against movement of the bumper-carrying member from the upright position to the lowered position and can preferably move the bumper-carrying member from the lowered position to the upright position. One of the bumper-carrying member and the support member carries a detent and the other carries a movable latch and a latch actuator for moving the latch between an engagement position and a disengagement position, with the latch biased into the engagement position so that the latch can selectively retain the bumper-carrying member in the upright position. A system to maintain pressure in a spare tire is also described.
摘要翻译： 保险杠安装组件包括可安装到车辆前部的支撑构件和铰接地安装到支撑构件的保险杠承载构件，以在直立位置和下降位置之间移动。 主促动器被固定到支撑构件和保险杠承载构件上，并且可以施加制动力以抵抗保险杠承载构件从直立位置到降低位置的移动，并且可以优选地将保险杠承载构件从降低位置移动到 直立的位置。 保险杠承载构件和支撑构件中的一个承载棘爪，另一个承载有可动闩锁和闩锁致动器，用于在接合位置和脱离位置之间移动闩锁，其中闩锁偏置到接合位置，使得闩锁 可以将保险杠承载构件选择性地保持在直立位置。 还描述了保持备用轮胎中的压力的系统。
-
公开(公告)号：US4541475A
公开(公告)日：1985-09-17
申请号：US451197
申请日：1982-12-20
申请人： John Goddard , David Mills , Alan J. Moulden
发明人： John Goddard , David Mills , Alan J. Moulden
摘要： Apparatus for casting in a vacuum has a single evacuable furnace chamber 10 in which the charge melting and mould heating takes place. The charge is melted in a crucible 24 by an induction coil 20, while the mould is heated by resistance heaters 18 which are made from a FECRALLOY (Registered Trade Mark) material and can be operated in air or vacuum. In operation an empty mould 16 and a charged crucible 24 are positioned in the furnace 14 and the furnace chamber is sealed. The heaters 20 and 18 are operated while the furnace is pumped down. A control device 40 ensures that the charge is not melted until the appropriate vacuum level has been reached. After pouring the filled mould is withdrawn into a withdrawal zone 25 and as soon as the casting has solidified to the extent that air can be admitted to the chamber without detriment, the vacuum is released and the mould and charge replaced. The furnace described is relatively inexpensive, having no water cooled valves between chambers, and the process is relatively quick and inexpensive due to the heating of the mould during evacuation of the chamber.
摘要翻译： 用于在真空中铸造的装置具有单个可抽出的炉室10，其中发生电荷熔融和模具加热。 通过感应线圈20将电荷熔化在坩埚24中，同时通过由FECRALLOY（注册商标）材料制成的电阻加热器18加热模具并且可以在空气或真空中操作。 在操作中，将空模16和带电的坩埚24定位在炉14中，并且将炉室密封。 加热器20和18在炉子被抽出的同时操作。 控制装置40确保在达到适当的真空度之前电荷不被熔化。 在将填充的模具倒出之后，将其注入到退避区域25中，一旦铸件凝固到空气可以进入腔室而没有损害的程度，则释放真空并且更换模具和电荷。 所描述的炉子相对便宜，在室之间没有水冷阀，并且由于在抽空室内的模具的加热，该方法相对快速和便宜。
-
10.发明授权Method of manufacture of articles with internal passages therein and articles made by the method 失效具有内部通道的制品的制造方法和通过该方法制造的制品
公开(公告)号：US4416321A
公开(公告)日：1983-11-22
申请号：US280213
申请日：1981-07-06
申请人： John Goddard , David Mills
发明人： John Goddard , David Mills
CPC分类号： B22C9/04 , B22D27/045
摘要： In casting of hollow turbine blades problems arise with breakage or distortion of long thin cores for small diameter cooling passages, and also in maintaining cores accurately positioned for casting thin walled blades. The present invention provides a method of manufacture in which a pre-form of the blade, or other hollow article, is made in two parts and is accurately machined to define the required passage shapes or wall thicknesses in at least one of the parts, appropriate cores are made and the pre-form parts are assembled in a casting mould with the cores in position and heated to melt the preforms. Thus the cores are supported by solid material during the melting process. The melting can take place progressively in a uni-directional manner along the article so that only a narrow area of the article becomes melted at any time and the cores are supported in the melt from both ends. Thus columnar grained or single crystal articles can be made by this method. The method can also be used to produce blind-ended holes in a cast article.
摘要翻译： 在中空涡轮机叶片的铸造中，由于用于小直径冷却通道的长的细芯的断裂或变形以及用于铸造薄壁叶片的精确定位的芯子，存在问题。 本发明提供了一种制造方法，其中叶片或其它中空制品的预成型件制成两部分并且被精确加工以在至少一个部件中限定所需的通道形状或壁厚，适当的 制造芯部，并且将预成型部件组装在铸造模具中，使芯部在适当位置并被加热以熔化预制件。 因此，芯在熔化过程中由固体材料支撑。 熔化可以沿着制品以单向方式逐渐进行，使得只有制品的狭窄区域随时熔化并且芯部从两端支撑在熔体中。 因此，可以通过该方法制造柱状晶粒或单晶制品。 该方法也可用于在铸造制品中产生盲孔。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.03 秒)