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1.6-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS 有权
标题翻译: 6-取代的2,3,4,5-四氢-1H-苯并[D]亚胺酯作为5-HT 2C受体激动剂公开(公告)号:US20090099155A1
公开(公告)日:2009-04-16
申请号:US10598302
申请日:2005-09-09
申请人: John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip Mazanetz
发明人: John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip Mazanetz
IPC分类号: A61K31/55 , C07D223/16 , C07D417/12 , C07D401/12 , A61P3/04 , A61P25/22 , C07D409/12 , C07D403/12 , C07D405/12
CPC分类号: C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzoazepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is -C≡C-R10, -O-R12, -S-R14, or -NR24R25; and other substituents are as defined in the specification.
摘要翻译: 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并吖庚因作为选择性5-HT 2C受体激动剂用于治疗5-HT2C相关疾病,包括肥胖,强迫症/强迫症,抑郁症和 焦虑:其中:R6为-C≡C-R10,-O-R12,-S-R14或-NR24R25; 和其它取代基如说明书中所定义。
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2.6 Substituted 2, 3,4,5 Tetrahydro-1H-Benzo[d]Azepines as 5-HT2c Receptor Agonist 失效
标题翻译: 6-取代2,3,4,5四氢-1H-苯并[d]氮杂环庚烷为5-HT2c受体激动剂公开(公告)号:US20120028961A1
公开(公告)日:2012-02-02
申请号:US13192707
申请日:2011-07-28
申请人: JOHN GORDON ALLEN , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip MAZANETZ
发明人: JOHN GORDON ALLEN , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Steven Armen Boyd , Richard Gerard Conway , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh , Michael Philip MAZANETZ
CPC分类号: C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —S—R14; and other substituents are as defined in the specification.
摘要翻译: 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂,用于治疗5-HT 2C相关病症,包括肥胖,强迫症/强迫症 ,抑郁症和焦虑症:其中:R6为-S-R14; 和其它取代基如说明书中所定义。
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3.6 substituted 2, 3,4,5 tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonist 失效
标题翻译: 6-取代的2,3,4,5四氢-1H-苯并[d]吖庚因,为5-HT 2C受体激动剂公开(公告)号:US08580780B2
公开(公告)日:2013-11-12
申请号:US13192707
申请日:2011-07-28
申请人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Deyi Zhang , Steven Armen Boyd , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh
发明人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Deyi Zhang , Steven Armen Boyd , Arundhati S. Deo , Wai-Man Lee , Christopher Stephen Siedem , Ajay Singh
IPC分类号: A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/55 , C07D223/16 , C07D401/12 , C07D417/12 , C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/14 , C07D417/06 , C07D403/06
CPC分类号: C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —S—R14; and other substituents are as defined in the specification.
摘要翻译: 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂,用于治疗5-HT 2C相关病症,包括肥胖,强迫症/强迫症 ,抑郁症和焦虑症:其中:R6为-S-R14; 和其它取代基如说明书中所定义。
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4.6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists 有权
标题翻译: 6-取代的2,3,4,5-四氢-1H-苯并[d]吖庚因,为5-HT 2C受体激动剂公开(公告)号:US08022062B2
公开(公告)日:2011-09-20
申请号:US10598302
申请日:2005-02-18
申请人: John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
发明人: John Gordon Allen , Karin Briner , Michael Philip Cohen , Christopher Stanley Galka , Sarah Lynne Hellman , Maria Angeles Martinez-Grau , Matthew Robert Reinhard , Michael John Rodriguez , Roger Ryan Rothhaar , Michael Wade Tidwell , Frantz Victor , Andrew Caerwyn Williams , Deyi Zhang , Michael Philip Mazanetz
IPC分类号: A61P3/04 , A61P25/22 , A61P25/24 , A61P25/30 , A61K31/55 , C07D223/16 , C07D401/12 , C07D417/12 , C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12 , C07D413/14 , C07D417/06 , C07D403/06
CPC分类号: C07D223/16 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula I as selective 5-HT2C receptor agonists for the treatment of 5-HT2C associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: where: R6 is —C≡C—R10, —O—R12, —S—R14, or —NR24R25; and other substituents are as defined in the specification.
摘要翻译: 本发明提供式I的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂,用于治疗5-HT 2C相关病症,包括肥胖,强迫症/强迫症 ,抑郁症和焦虑症:其中:R6是-C≡C-R10,-O-R12,-S-R14或-NR24R25; 和其它取代基如说明书中所定义。
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5.6-Arylalkylamino-2,3,4,5-Tetrahydro-1H-Benzo[D]Azepines as 5-Ht2c Receptor Agonists 审中-公开
标题翻译: 6-芳基烷基氨基-2,3,4,5-四氢-1H-苯并[D]氮杂卓作为5-Ht2c受体激动剂公开(公告)号:US20080269196A1
公开(公告)日:2008-10-30
申请号:US11996751
申请日:2006-09-01
申请人: Karin Briner , Maria Adeva Bartolome , Manuel Javier Cases-Thomas , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O' Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
发明人: Karin Briner , Maria Adeva Bartolome , Manuel Javier Cases-Thomas , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O' Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
IPC分类号: A61K31/55 , C07D223/16
CPC分类号: C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is —NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
摘要翻译: 本发明提供式(I)的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂,用于治疗5-HT2c相关疾病,包括肥胖,强迫症/ 强迫症,抑郁症和焦虑症,其中R6是-NR10R11,其中R10是取代的苯基烷基或取代的吡啶基烷基和其它取代基如说明书中所定义。
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6.6-arylalkylamino-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists 失效
标题翻译: 6-芳基烷基氨基-2,3,4,5-四氢-1H-苯并[d]吖庚因,为5-HT 2C受体激动剂公开(公告)号:US08680091B2
公开(公告)日:2014-03-25
申请号:US13156575
申请日:2011-06-09
申请人: Karen Briner , Manuel Javier Cases-Thomas , Marta Adeva Bartolome , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O'Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
发明人: Karen Briner , Manuel Javier Cases-Thomas , Marta Adeva Bartolome , Christopher Stanley Galka , Alicia Marcos Llorente , Maria Angeles Martinez-Grau , Michael Philip Mazanetz , John Cunningham O'Toole , Richard Edmund Rathmell , Matthew Robert Reinhard , Selma Sapmaz , Andrew Caerwyn Williams
IPC分类号: A61K31/55 , C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
CPC分类号: C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is —NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.
摘要翻译: 本发明提供式(I)的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性5-HT 2C受体激动剂,用于治疗5-HT2c相关疾病,包括肥胖,强迫症/ 强迫症,抑郁症和焦虑症,其中R6是-NR10R11,其中R10是取代的苯基烷基或取代的吡啶基烷基和其它取代基如说明书中所定义。
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7.6-Substituted-2,3,4,5-Tetrahydro-1H-Benzo[d]Azepines as 5-Ht2c Receptor Agonists 有权
标题翻译: 6-取代的2,3,4,5-四氢-1H-苯并[d]氮杂卓作为5-Ht2c受体激动剂公开(公告)号:US20080255092A1
公开(公告)日:2008-10-16
申请号:US11996457
申请日:2006-09-01
申请人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
发明人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
IPC分类号: A61K31/55 , C07D223/16
CPC分类号: C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R?N—R″R* where R6 is —(CrC3)alkyl-S—(C0-C3)alkyl-R10, —(C1-C3)alkyl-NR11R12, —(CrC3)alkyl-O—R13. and other substituents are as defined in the specification.
摘要翻译: 本发明提供式(I)的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性的5-HT 2C受体激动剂,用于治疗5-HT2c相关疾病,包括肥胖,强迫症/ 强迫症,抑郁症和焦虑症:R6 DR?N-R''R *其中R6是 - (CrC3)烷基-S-(C0-C3)烷基-R10, - (C1-C3)烷基-NR11R12 - ( C 1 -C 3烷基-O-R 13。 和其它取代基如说明书中所定义。
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8.6-substituted-2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2C receptor agonists 有权
标题翻译: 6-取代-2,3,4,5-四氢-1H-苯并[d]吖庚因,为5-HT 2C受体激动剂公开(公告)号:US07994163B2
公开(公告)日:2011-08-09
申请号:US11996457
申请日:2006-09-01
申请人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
发明人: John Gordon Allen , Karin Briner , Christopher Stanley Galka , Richard Charles Hoying , Maria Angeles Martinez-Grau , Julie Miyashiro , Natalia Pokrovskaia , Matthew Robert Reinhard
IPC分类号: A61P3/04 , A61P25/00 , A61P25/22 , A61P25/24 , A61K31/55 , C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
CPC分类号: C07D223/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要: The present invention provides 6-substituted 2,3,4,5-tetrahydro-1H-benzo[d]azepines of Formula (I) as selective 5-HT2C receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety: R6 D R?N—R″R* where R6 is —(CrC3)alkyl-S—(C0-C3)alkyl-R10, —(C1-C3)alkyl-NR11R12, —(CrC3)alkyl-O—R13. and other substituents are as defined in the specification.
摘要翻译: 本发明提供式(I)的6-取代2,3,4,5-四氢-1H-苯并[d]吖庚因作为选择性的5-HT 2C受体激动剂,用于治疗5-HT2c相关疾病,包括肥胖,强迫症/ 强迫症,抑郁症和焦虑症:R6 DR?N-R“R *其中R6是 - (CrC3)烷基-S-(C0-C3)烷基-R10, - (C1-C3)烷基-NR11R12 - (CrC3 )烷基-O-R13。 和其它取代基如说明书中所定义。
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公开(公告)号:US06881733B1
公开(公告)日:2005-04-19
申请号:US10031414
申请日:2000-07-21
申请人: Karin Briner , Joseph Paul Burkhart , Timothy Paul Burkholder , Brian Eugene Cunningham , Matthew Joseph Fisher , William Harlan Gritton , Cynthia Darshini Jesudason , Shawn Christopher Miller , Jeffrey Thomas Mullaney , Matthew Robert Reinhard , Roger Ryan Rothhaar , Freddie Craig Stevens , Leonard Larry Winneroski , Yanping Xu , Yao-Chang Xu
发明人: Karin Briner , Joseph Paul Burkhart , Timothy Paul Burkholder , Brian Eugene Cunningham , Matthew Joseph Fisher , William Harlan Gritton , Cynthia Darshini Jesudason , Shawn Christopher Miller , Jeffrey Thomas Mullaney , Matthew Robert Reinhard , Roger Ryan Rothhaar , Freddie Craig Stevens , Leonard Larry Winneroski , Yanping Xu , Yao-Chang Xu
IPC分类号: A61K31/4025 , A61K31/4525 , A61K31/55 , A61P25/24 , C07D405/04 , C07D413/04
CPC分类号: C07D405/04
摘要: The present invention provides serotonergic benzofurans of Formula (I): where A, R, R1, R2, R3, and R4 are as described in the specification.
摘要翻译: 本发明提供式(I)的5-羟色胺能的苯并呋喃:其中A,R,R 1,R 2,R 3和R 3, SUP> 4 SUP>如说明书中所述。
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10.Benzofurylpiperazines and benzofurylhomopiperazines: serotonin agonists 失效
标题翻译: 苯并呋喃基哌嗪和苯并呋喃基哌嗪嗪:5-羟色胺激动剂公开(公告)号:US06967201B1
公开(公告)日:2005-11-22
申请号:US10031312
申请日:2000-07-21
申请人: Karin Briner , Joseph Paul Burkhart , Timothy Paul Burkholder , Brian Eugene Cunningham , Matthew Joseph Fisher , William Harlan Gritton , Shawn Christopher Miller , Jeffrey Thomas Mullaney , Matthew Robert Reinhard , Dennis Charles Thompson , Leonard Larry Winneroski , Yanping Xu
发明人: Karin Briner , Joseph Paul Burkhart , Timothy Paul Burkholder , Brian Eugene Cunningham , Matthew Joseph Fisher , William Harlan Gritton , Shawn Christopher Miller , Jeffrey Thomas Mullaney , Matthew Robert Reinhard , Dennis Charles Thompson , Leonard Larry Winneroski , Yanping Xu
IPC分类号: A61K31/496 , A61K31/551 , A61P3/04 , A61P25/24 , A61P43/00 , C07D307/79 , C07D405/04 , C07D405/10 , C07D405/12
CPC分类号: C07D307/79 , C07D405/04 , C07D405/12
摘要: The present invention provides serotonergic benzofurylpiperazines of Formula I: where: A is a piperazine of formula: and R, R1, R2, R3, R4, R5, R5′, R6, R6′, R7, R7′, R8, and R8′ are as described in the specification.
摘要翻译: 本发明提供式I的5-羟色胺苯并呋喃基哌嗪:其中:A是下式的哌嗪和R 1,R 1,R 2,R 3, R 4,R 5,R 5,R 6,R 6,R 6, R SUP,R 7,R 7,R 8和R 8'如上所述 规格。
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