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公开(公告)号：US07205278B2
公开(公告)日：2007-04-17
申请号：US10172712
申请日：2002-06-14
IPC分类号： A61K38/36 , C07K14/475
CPC分类号： C07K1/1075 , A61K38/00 , C07K1/107 , C07K14/745 , C07K14/755
摘要： The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. The invention also relates to polypeptides containing such introduced cysteine residue(s), nucleic acids encoding such polypeptides and pharmaceutical compositions comprising such polypeptides or nucleic acids. The invention also relates to vectors, viral particles and host cells containing such nucleic acids, and methods of using them to produce the polypeptides of the invention. Exemplified polypeptides include plasma proteins, including hepatocyte growth factor activator and plasma hyaluronin binding protein, as well as blood coagulation factors, such as Factor VIII, Factor V, Factor XII and prothrombin.
摘要翻译： 本发明涉及将一种或多种半胱氨酸残基引入多肽的方法，所述多肽允许通过在多肽的不同结构域之间形成至少一个键，优选二硫键来稳定多肽。 本发明还涉及含有这种引入的半胱氨酸残基的多肽，编码这些多肽的核酸和包含这种多肽或核酸的药物组合物。 本发明还涉及含有这种核酸的载体，病毒颗粒和宿主细胞，以及使用它们产生本发明多肽的方法。 示例性多肽包括血浆蛋白，包括肝细胞生长因子激活剂和血浆透明质酸结合蛋白，以及凝血因子，如因子VIII，因子V，因子XII和凝血酶原。
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公开(公告)号：US07928199B2
公开(公告)日：2011-04-19
申请号：US11627197
申请日：2007-01-25
IPC分类号： C07K14/755 , A61K38/36
CPC分类号： C07K1/1075 , A61K38/00 , C07K1/107 , C07K14/745 , C07K14/755
摘要： The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. The invention also relates to polypeptides containing such introduced cysteine residue(s), nucleic acids encoding such polypeptides and pharmaceutical compositions comprising such polypeptides or nucleic acids. The invention also relates to vectors, viral particles and host cells containing such nucleic acids, and methods of using them to produce the polypeptides of the invention. Exemplified polypeptides include plasma proteins, including hepatocyte growth factor activator and plasma hyaluronin binding protein, as well as blood coagulation factors, such as Factor VIII, Factor V, Factor XII and prothrombin.
摘要翻译： 本发明涉及将一种或多种半胱氨酸残基引入多肽的方法，所述多肽允许通过在多肽的不同结构域之间形成至少一个键，优选二硫键来稳定多肽。 本发明还涉及含有这种引入的半胱氨酸残基的多肽，编码这些多肽的核酸和包含这种多肽或核酸的药物组合物。 本发明还涉及含有这种核酸的载体，病毒颗粒和宿主细胞，以及使用它们产生本发明多肽的方法。 示例性多肽包括血浆蛋白，包括肝细胞生长因子激活剂和血浆透明质酸结合蛋白，以及凝血因子，如因子VIII，因子V，因子XII和凝血酶原。
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公开(公告)号：US20070276128A1
公开(公告)日：2007-11-29
申请号：US11627197
申请日：2007-01-25
IPC分类号： C07K14/755 , C07K1/00
CPC分类号： C07K1/1075 , A61K38/00 , C07K1/107 , C07K14/745 , C07K14/755
摘要： The present invention relates to methods of introducing one or more cysteine residues into a polypeptide which permit the stabilization of the polypeptide by formation of at least one bond, preferably a disulfide bond, between different domains of the polypeptide. The invention also relates to polypeptides containing such introduced cysteine residue(s), nucleic acids encoding such polypeptides and pharmaceutical compositions comprising such polypeptides or nucleic acids. The invention also relates to vectors, viral particles and host cells containing such nucleic acids, and methods of using them to produce the polypeptides of the invention. Exemplified polypeptides include plasma proteins, including hepatocyte growth factor activator and plasma hyaluronin binding protein, as well as blood coagulation factors, such as Factor VIII, Factor V, Factor XII and prothrombin.
摘要翻译： 本发明涉及将一种或多种半胱氨酸残基引入多肽的方法，所述多肽允许通过在多肽的不同结构域之间形成至少一个键，优选二硫键来稳定多肽。 本发明还涉及含有这种引入的半胱氨酸残基的多肽，编码这些多肽的核酸和包含这种多肽或核酸的药物组合物。 本发明还涉及含有这种核酸的载体，病毒颗粒和宿主细胞，以及使用它们产生本发明多肽的方法。 示例性多肽包括血浆蛋白，包括肝细胞生长因子激活剂和血浆透明质酸结合蛋白，以及凝血因子，如因子VIII，因子V，因子XII和凝血酶原。
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