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1.Anti-depressant spiro hexahydro arylquinolizine derivatives, composition, and method of use therefor 失效
标题翻译: 抗抑郁螺旋六氢芳基喹啉衍生物,组合物及其用途公开(公告)号:US4710504A
公开(公告)日:1987-12-01
申请号:US848262
申请日:1986-04-04
申请人: John J. Baldwin , Joel R. Huff , Joseph P. Vacca , Steven D. Young , Jane deSolms , James P. Guare, Jr.
发明人: John J. Baldwin , Joel R. Huff , Joseph P. Vacca , Steven D. Young , Jane deSolms , James P. Guare, Jr.
IPC分类号: C07D471/20 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22 , A61K31/415 , A61K31/305 , C07D455/00
CPC分类号: C07D471/20 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22
摘要: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
摘要翻译: 取代的六氢芳基喹啉及其药学上可接受的盐是选择性α2-肾上腺素能受体拮抗剂,因此可用作抗抑郁药,抗高血压药,眼用抗高血压药,抗糖尿病药,血小板聚集抑制剂,抗肥胖剂和消化道运动性改良剂。
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公开(公告)号:US4824849A
公开(公告)日:1989-04-25
申请号:US90641
申请日:1987-08-28
申请人: John J. Baldwin , Joel R. Huff , Joseph P. Vacca , Steven D. Young , Jane deSolms , James P. Guare, Jr.
发明人: John J. Baldwin , Joel R. Huff , Joseph P. Vacca , Steven D. Young , Jane deSolms , James P. Guare, Jr.
IPC分类号: C07D471/20 , C07D471/22 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22 , A61K31/415 , A61K31/305 , C07D455/00
CPC分类号: C07D471/20 , C07D471/22 , C07D491/22 , C07D495/22 , C07D498/22 , C07D513/22
摘要: Substituted hexahydro arylquinolizines and pharmaceutically acceptable salts thereof are selective .alpha..sub.2 -adrenergic receptor antagonists and thereby useful as antidepressants, antihypertensives, ocular antihypertensives, antidiabetics, platelet aggregation inhibitors, antiobesity agents, and modifiers of gastrointestinal motility.
摘要翻译: 取代的六氢芳基喹啉及其药学上可接受的盐是选择性α2-肾上腺素能受体拮抗剂,因此可用作抗抑郁药,抗高血压药,眼用抗高血压药,抗糖尿病药,血小板聚集抑制剂,抗肥胖剂和消化道运动性改良剂。
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