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公开(公告)号:US20050123533A1
公开(公告)日:2005-06-09
申请号:US10699966
申请日:2003-11-03
申请人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
发明人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
IPC分类号: A61K31/195 , A61K31/425 , A61K31/505 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K39/385 , A61K39/395 , A61K47/48 , A61P31/12 , A61P43/00 , C07C311/19 , C07D227/02 , C07D233/64 , C07D233/88 , C07D405/04 , C07D417/12 , C07D417/14 , C07F9/24 , C07F9/26 , C07F9/40 , C07F9/6509 , C07F9/6571 , C07F9/6574 , C07H15/252 , C07H19/04 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/11 , C07K16/46 , C12N15/09 , C12P21/08 , C12R1/92 , G01N33/50 , G01N33/53 , C07H15/24 , C07K16/18
CPC分类号: G01N33/5011 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K16/468 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5094 , G01N2500/00
摘要: Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
摘要翻译: 披露和要求的是由催化蛋白如酶和催化抗体活化的前药。 本发明包括这些前药以及半抗原以引发催化抗体以活化前药。 前药可用作细胞毒性化学治疗剂; 例如作为抗肿瘤剂。
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公开(公告)号:US6087476A
公开(公告)日:2000-07-11
申请号:US906654
申请日:1997-08-07
申请人: John H. Kenten , Jan Casadei , Michael J. Powell
发明人: John H. Kenten , Jan Casadei , Michael J. Powell
IPC分类号: C07K14/16 , C07K14/435 , C07K16/18 , C07K16/44 , C12N15/62 , G01N33/533 , G01N33/58 , C07K14/00 , C12N9/00
CPC分类号: C07K14/005 , C07K14/43595 , C07K16/18 , C07K16/44 , C12N15/62 , G01N33/533 , G01N33/582 , C07K2319/00 , C07K2319/40 , C07K2319/60 , C07K2319/735 , C12N2740/16122
摘要: The invention relates to luminescent chimeric proteins which include a photoprotein and a second protein which may be light- or heavy-chain immunoglobulin, an antigenic peptide, avidin, streptavidin, or protein A. The invention also relates to chimeric protein genes, plasmids containing said gene, and hosts transformed with said plasmid. The invention also relates to a range of highly sensitive immunoassays which use the chimeric proteins.
摘要翻译: 本发明涉及发光嵌合蛋白,其包括光蛋白和可以是轻链或重链免疫球蛋白,抗原肽,抗生物素蛋白,链霉亲和素或蛋白A的第二蛋白。本发明还涉及嵌合蛋白基因,含有所述 基因和用所述质粒转化的宿主。 本发明还涉及使用嵌合蛋白的一系列高度灵敏的免疫测定。
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