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公开(公告)号:US20050123533A1
公开(公告)日:2005-06-09
申请号:US10699966
申请日:2003-11-03
申请人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
发明人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
IPC分类号: A61K31/195 , A61K31/425 , A61K31/505 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K39/385 , A61K39/395 , A61K47/48 , A61P31/12 , A61P43/00 , C07C311/19 , C07D227/02 , C07D233/64 , C07D233/88 , C07D405/04 , C07D417/12 , C07D417/14 , C07F9/24 , C07F9/26 , C07F9/40 , C07F9/6509 , C07F9/6571 , C07F9/6574 , C07H15/252 , C07H19/04 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/11 , C07K16/46 , C12N15/09 , C12P21/08 , C12R1/92 , G01N33/50 , G01N33/53 , C07H15/24 , C07K16/18
CPC分类号: G01N33/5011 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K16/468 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5094 , G01N2500/00
摘要: Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
摘要翻译: 披露和要求的是由催化蛋白如酶和催化抗体活化的前药。 本发明包括这些前药以及半抗原以引发催化抗体以活化前药。 前药可用作细胞毒性化学治疗剂; 例如作为抗肿瘤剂。
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公开(公告)号:US06702705B1
公开(公告)日:2004-03-09
申请号:US08392407
申请日:1995-02-22
申请人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人: Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号: C12N900
CPC分类号: C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要: Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译: 公开了催化抗体。 催化抗体对前药化合物是特异性的。 催化抗体增强了活性药物部分与前药残留物的切割,从而激活了药物。
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公开(公告)号:US20050181430A1
公开(公告)日:2005-08-18
申请号:US11090061
申请日:2005-03-28
申请人: John Kenten , Rodger Smith
发明人: John Kenten , Rodger Smith
CPC分类号: C07H23/00 , C07H21/00 , C12Q1/6804 , C12Q1/6816 , C12Q1/6851 , C12Q1/686 , C12Q1/6865 , C12Q1/703 , C12Q2535/113 , C12Q2563/113
摘要: This invention relates to an improved process for detecting and quantifying a desired nucleic acid sequence. The process involves synthesizing single stranded RNA, single stranded DNA, double-stranded DNA followed by detection using an electrochemiluminescent labeled binding species.
摘要翻译: 本发明涉及用于检测和定量所需核酸序列的改进方法。 该方法包括合成单链RNA,单链DNA,双链DNA,然后使用电化学发光标记的结合物质进行检测。
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公开(公告)号:US20050164410A1
公开(公告)日:2005-07-28
申请号:US10912574
申请日:2004-08-06
申请人: John Leland , Haresh Shah , John Kenten , Jack Goodman , George Lowke , Yuzaburo Namba , Gary Blackburn , Richard Massey
发明人: John Leland , Haresh Shah , John Kenten , Jack Goodman , George Lowke , Yuzaburo Namba , Gary Blackburn , Richard Massey
CPC分类号: G01N33/582 , C07H21/00 , G01N1/40 , G01N21/66 , G01N21/76 , G01N33/54313 , G01N33/54326 , G01N33/54366 , G01N33/5438
摘要: An apparatus for performing a binding assay for an analyte of interest present in a sample based upon measurement of electrochemiluminescence at an electrode surface comprising a cell defining a sample containing volume intersecting with inlet and outlet means, an electrode having a substantially horizontally positioned surface exposed to and positioned below a portion of the sample containing volume, means for impressing electrochemical energy upon said electrode sufficient to generate luminescence, means for magnetically collecting particles along said surface and means for measuring the luminescence generated at said electrode.
摘要翻译: 基于在包括限定与入口和出口装置相交的体积的样品的细胞的电极表面上测量电化学发光,对样品中存在的感兴趣分析物进行结合测定的装置,具有暴露于 并且位于所述样品容纳体积的一部分下方,用于在所述电极上施加足以产生发光的电化学能量的装置,用于沿着所述表面磁性收集颗粒的装置和用于测量在所述电极处产生的发光的装置。
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公开(公告)号:US20060211718A1
公开(公告)日:2006-09-21
申请号:US10545547
申请日:2004-02-12
申请人: Allan Weissman , Karen Vousden , Jane Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John Kenten , Ilia Davydov , Yassamin Safiran , Pankaj Oberoi
发明人: Allan Weissman , Karen Vousden , Jane Jensen , Yili Yang , Shengyun Fang , Douglas Woods , John Kenten , Ilia Davydov , Yassamin Safiran , Pankaj Oberoi
IPC分类号: A61K31/519 , C07D487/02
CPC分类号: C07D471/04
摘要: The present invention features 5-deazaflavin compounds, pharmaceutical compositions of 5-deazaflavin compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more 5-deazaflavin compounds of the invention.
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公开(公告)号:US20060121051A1
公开(公告)日:2006-06-08
申请号:US11225687
申请日:2005-09-12
申请人: John Kenten , Steven Roberts , Gerald Lohnas
发明人: John Kenten , Steven Roberts , Gerald Lohnas
IPC分类号: A61K39/00 , C07K14/525
CPC分类号: A61K39/0006 , A61K39/385 , A61K2039/6043
摘要: Disclosed are self-epitope-containing heat shock fusion proteins, DNA constructs encoding such fusion proteins, and methods of use. More specifically, disclosed are ubiquitin fusion proteins comprising ubiquitin fused to a plurality of identical or non-identical self-epitopes at specified locations. Immunization of an animal with these ubiquitin fusion proteins elicits an immune response to self-antigens present on endogenous proteins. Generation of an immune response to a specified self-antigen is a mechanism to decrease the levels of the endogenous protein below base-line.
摘要翻译: 公开了含有自身表位的热休克融合蛋白,编码这种融合蛋白的DNA构建体和使用方法。 更具体地,披露了包含在指定位置融合到多个相同或不相同自身表位的泛素的泛素融合蛋白。 用这些泛素融合蛋白免疫动物引起对存在于内源蛋白上的自身抗原的免疫应答。 产生对特定自身抗原的免疫应答是降低底线以下内源性蛋白质水平的机制。
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