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公开(公告)号:US20050123533A1
公开(公告)日:2005-06-09
申请号:US10699966
申请日:2003-11-03
申请人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
发明人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
IPC分类号: A61K31/195 , A61K31/425 , A61K31/505 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K39/385 , A61K39/395 , A61K47/48 , A61P31/12 , A61P43/00 , C07C311/19 , C07D227/02 , C07D233/64 , C07D233/88 , C07D405/04 , C07D417/12 , C07D417/14 , C07F9/24 , C07F9/26 , C07F9/40 , C07F9/6509 , C07F9/6571 , C07F9/6574 , C07H15/252 , C07H19/04 , C07H19/067 , C07H19/09 , C07H19/10 , C07H19/11 , C07K16/46 , C12N15/09 , C12P21/08 , C12R1/92 , G01N33/50 , G01N33/53 , C07H15/24 , C07K16/18
CPC分类号: G01N33/5011 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K16/468 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/5094 , G01N2500/00
摘要: Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
摘要翻译: 披露和要求的是由催化蛋白如酶和催化抗体活化的前药。 本发明包括这些前药以及半抗原以引发催化抗体以活化前药。 前药可用作细胞毒性化学治疗剂; 例如作为抗肿瘤剂。