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公开(公告)号:US20080187531A1
公开(公告)日:2008-08-07
申请号:US11876669
申请日:2007-10-22
申请人: John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
发明人: John S. Babcook , Jaspal S. Kang , Orit Foord , Larry Green , Xiao Feng , Scott Klakamp , Mary Haak-Frendscho , Palaniswami Rathanaswami , Craig Pigott , Meina Liang , Yen-Wah "Rozanne" Lee , Kathy Manchulenko , Raffaella Faggioni , Giorgio Senaldi , Qiaojuan Jane Su
IPC分类号: A61K39/395 , C07K16/00
CPC分类号: C07K16/241 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要: Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译: 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列,特别是对应于跨越框架区和/或互补决定区(CDR)的连续重链和轻链序列的序列,特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。