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公开(公告)号:US20090311226A1
公开(公告)日:2009-12-17
申请号:US12300685
申请日:2007-05-22
申请人: John W. Harmon , Guy Pierre Marti , Tomoharu Miyashita , Michael Gibson , Todd Armstrong , Pramod Bonde
发明人: John W. Harmon , Guy Pierre Marti , Tomoharu Miyashita , Michael Gibson , Todd Armstrong , Pramod Bonde
CPC分类号: A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要: Enhancing the immune response to esophageal tumor cells reduces the incidence of esophageal cancer developing, recurring, or metastasizing. Esophageal cancer cells are modified to render them more immunogenic and proliferation compromised. They are used in an antigenic preparation to raise a T cell response in the recipient.
摘要翻译: 增强对食管肿瘤细胞的免疫反应降低食管癌发生,复发或转移的发生率。 食管癌细胞被修饰以使其更具免疫原性和增殖受损。 它们用于抗原制剂以提高受体中的T细胞应答。
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公开(公告)号:US20090030364A1
公开(公告)日:2009-01-29
申请号:US11883554
申请日:2006-02-06
IPC分类号: A61N1/30
CPC分类号: A61N1/0412 , A61N1/325 , A61N1/327
摘要: A cartridge for administration of a bioactive agent may include a plurality of chambers, including at least a first chamber and a second chamber. Each of the chambers may contain a component of a composition to be administered to a tissue site of a subject. For example, the first chamber may contain the bioactive agent and the second chamber may contain a liquid for suspending the bioactive agent prior to administration to the tissue site. An apparatus for administering or delivering a bioactive agent may include the cartridge and may further include an energy source for providing an electrical pulse to the tissue site. The apparatus may further cause mixing of the bioactive agent with the liquid in the cartridge. For example, the apparatus may impact the cartridge to result in mixing of the bioactive agent with the liquid. A method for combining a bioactive agent with a liquid forms a composition for delivering to a tissue site.
摘要翻译: 用于施用生物活性剂的药筒可以包括多个室,包括至少第一室和第二室。 每个室可以含有待施用于受试者的组织部位的组合物的组分。 例如,第一室可含有生物活性剂,第二室可含有用于在给予组织部位之前悬浮生物活性剂的液体。 用于施用或递送生物活性剂的装置可以包括筒,并且还可以包括用于向组织部位提供电脉冲的能量源。 该装置还可以使生物活性剂与药筒中的液体混合。 例如,该装置可能会影响药筒,导致生物活性剂与液体的混合。 将生物活性剂与液体组合的方法形成用于递送至组织部位的组合物。
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