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公开(公告)号:US5554612A
公开(公告)日:1996-09-10
申请号:US452243
申请日:1995-05-26
申请人: John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535 , C07D413/12
CPC分类号: C07D307/88
摘要: The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译: 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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公开(公告)号:US5633279A
公开(公告)日:1997-05-27
申请号:US483042
申请日:1995-06-06
申请人: David Morgans, Jr. , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: David Morgans, Jr. , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/42 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/83 , C07D307/88 , C07D405/06 , C07D405/10 , C07D407/06 , C07D407/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/12 , C07F9/655 , A61K31/445 , A61K31/535
CPC分类号: C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06 , C07D413/06 , C07F9/65517
摘要: The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.
摘要翻译: 公开的霉酚酸的己烯酸侧链衍生物是治疗药物,其有利于治疗指示霉酚酸和/或霉酚酸酯的疾病状态,包括免疫,炎性,肿瘤,增殖性,病毒性或牛皮癣性疾病。
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公开(公告)号:US5538969A
公开(公告)日:1996-07-23
申请号:US452245
申请日:1995-05-26
申请人: David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talam as , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fern andez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535 , C07D413/12
CPC分类号: C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06
摘要: The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译: 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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4.Method of using 4-amino derivatives of 5-substituted mycophenolic acid 失效
标题翻译: 使用5-取代霉酚酸的4-氨基衍生物的方法公开(公告)号:US5512568A
公开(公告)日:1996-04-30
申请号:US198732
申请日:1994-02-18
申请人: David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535
CPC分类号: C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06
摘要: The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译: 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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公开(公告)号:US5493030A
公开(公告)日:1996-02-20
申请号:US198749
申请日:1994-02-18
申请人: David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , John W. Patterson , John C. Rohloff , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/34 , A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61K31/42 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/83 , C07D307/88 , C07D405/06 , C07D405/10 , C07D407/06 , C07D407/10 , C07D409/06 , C07D409/10 , C07D413/06 , C07D413/12 , C07F9/655 , C07D263/22
CPC分类号: C07D405/06 , C07D307/88 , C07D407/06 , C07D409/06 , C07D413/06 , C07F9/65517
摘要: The disclosed hexenoic acid side-chain derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil, including immune, inflammatory, tumor, proliferative, viral or psoriatic disorders.
摘要翻译: 公开的霉酚酸的己烯酸侧链衍生物是治疗剂,其用于治疗指示霉酚酸和/或霉酚酸酯的疾病状态,包括免疫,炎症,肿瘤,增殖性,病毒性或银屑病性疾病。
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公开(公告)号:US5444072A
公开(公告)日:1995-08-22
申请号:US198725
申请日:1994-02-18
申请人: John W. Patterson , David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: John W. Patterson , David Morgans, Jr. , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: C07D307/88 , A61K20060101 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/535 , A61K31/54 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D20060101 , C07D307/83 , C07D405/02 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/00 , C07D413/12 , C07D417/00 , C07D417/12
CPC分类号: C07D307/83
摘要: The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
摘要翻译: 所公开的麦考酚酸的6-取代衍生物是治疗药物,其有利于治疗针对霉酚酸和/或霉酚酸酯的疾病状态。
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公开(公告)号:US5536747A
公开(公告)日:1996-07-16
申请号:US435255
申请日:1995-05-05
申请人: John W. Patterson , David Morgans, Jr. , David B. Smith , Fancisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: John W. Patterson , David Morgans, Jr. , David B. Smith , Fancisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Eric B. Sjogren , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: C07D307/88 , A61K20060101 , A61K31/34 , A61K31/341 , A61K31/365 , A61K31/38 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/445 , A61K31/535 , A61K31/54 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D20060101 , C07D307/83 , C07D405/02 , C07D405/06 , C07D405/10 , C07D405/12 , C07D407/06 , C07D407/10 , C07D407/12 , C07D409/06 , C07D409/10 , C07D413/00 , C07D413/12 , C07D417/00 , C07D417/12
CPC分类号: C07D307/83
摘要: The disclosed 6-substituted derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil.
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8.Method of using 4-amino 6-substituted mycophenolic acid and derivatives 失效
标题翻译: 使用4-氨基-6-取代霉酚酸及其衍生物的方法公开(公告)号:US5525602A
公开(公告)日:1996-06-11
申请号:US198741
申请日:1994-02-18
申请人: John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
发明人: John W. Patterson , David Morgans, Jr. , Eric B. Sjogren , David B. Smith , Francisco X. Talamas , Dean R. Artis , Alicia Cervantes , Todd R. Elworthy , Mario Fernandez , Fidencio Franco , Ronald C. Hawley , Teresa Lara , David G. Loughhead , Peter H. Nelson , Alejandra Trejo , Ann M. Waltos , Robert J. Weikert
IPC分类号: A61K31/365 , A61K31/38 , A61K31/40 , A61K31/4025 , A61P17/00 , A61P29/00 , A61P35/00 , A61P37/06 , C07D307/88 , C07D405/06 , C07D407/06 , C07D409/06 , A61K31/535
CPC分类号: C07D307/88
摘要: The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other immunosuppressant agents.
摘要翻译: 公开的霉酚酸衍生物是治疗针对霉酚酸和/或霉酚酸酯和其它免疫抑制剂的疾病状态的治疗剂。
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9.SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译: 螺环DIGYDRO-THIAZINE和DIHYDRO-OXAZINE BACE抑制剂及其组合物及其用途公开(公告)号:US20150087825A1
公开(公告)日:2015-03-26
申请号:US14556895
申请日:2014-12-01
申请人: Ying-Zi Xu , Dean R. Artis , Simeon Bowers , Roy K. Hom , Hing L. Sham , Shendong Yuan
发明人: Ying-Zi Xu , Dean R. Artis , Simeon Bowers , Roy K. Hom , Hing L. Sham , Shendong Yuan
IPC分类号: C07D513/10
CPC分类号: C07D513/10 , C07D265/12 , C07D265/18 , C07D279/08 , C07D279/16 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/10
摘要: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.
摘要翻译: 提供具有根据式(I)的结构的化合物:其中A1,A2,A3,Y,R1,R2,R3,R4,R5,R6,m,n和p如本文所定义。 还提供了药物组合物,其包括所提供的化合物和制备和使用所提供的化合物和组合物的方法,例如用于治疗和预防各种疾病如阿尔茨海默氏病。
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公开(公告)号:US08143271B2
公开(公告)日:2012-03-27
申请号:US13216200
申请日:2011-08-23
申请人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
发明人: Prabha N. Ibrahim , Dean R. Artis , Ryan Bremer , Chao Zhang , Jiazhong Zhang , James Tsai , Klaus-Peter Hirth , Gideon Bollag , Hanna Cho
IPC分类号: C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , A01N43/42 , A61K31/44
CPC分类号: C07D471/04 , A61K31/437 , A61K31/496 , A61K31/5377 , C07C37/62 , C07C39/27 , C07C45/00 , C07C45/673 , C07C45/71 , C07C47/565 , C07C47/575 , C07D209/08
摘要: Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
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