公开(公告)号：US20130230571A1

公开(公告)日：2013-09-05

申请号：US13878748

申请日：2011-10-03

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak Bhat

IPC分类号： A61L31/16 ,  A61L31/08

CPC分类号： A61L31/16 ,  A61K31/436 ,  A61K45/06 ,  A61L29/06 ,  A61L29/148 ,  A61L29/16 ,  A61L31/06 ,  A61L31/08 ,  A61L31/148 ,  C08L67/04 ,  A61K2300/00

摘要： The present disclosure provides a device for intracorporeal use which comprises an implant or a temporary device and at least one source of myolimus or a derivative thereof. The present disclosure also provides a method of inhibiting cell proliferation, inflammation or cytokine production by systemic or local administration of a therapeutically effective amount of myolimus or a derivative thereof. Further included in the present disclosure is a method of treating an ophthalmic condition or disease by administering a therapeutically effective amount of myolimus or a derivative thereof.

摘要翻译： 本公开提供了一种用于体内使用的装置，其包括植入物或临时装置以及至少一种肌醇来源或其衍生物。 本公开还提供了通过全身或局部施用治疗有效量的肌醇酰胺或其衍生物来抑制细胞增殖，炎症或细胞因子产生的方法。 本公开内容中还包括通过施用治疗有效量的肌醇酰胺或其衍生物来治疗眼科疾病或疾病的方法。

公开(公告)号：US20130055819A1

公开(公告)日：2013-03-07

申请号：US13330681

申请日：2011-12-20

申请人： John Yan

发明人： John Yan

IPC分类号： G01L9/00 ,  C08G77/38

CPC分类号： A61B3/16

摘要： The disclosed invention describes an unpowered apparatus which can wirelessly sense pressure based on microfluidics for point-of-care glaucoma diagnosis. Moreover, the disclosed invention teaches methods to construct the invention using microfabrication processing. Finally, a detailed and illustrative schematic of the wireless readout system is disclosed.

摘要翻译： 所公开的发明描述了一种无动力装置，其能够基于用于点护理青光眼诊断的微流体无线地感测压力。 此外，所公开的发明教导了使用微细加工处理来构建本发明的方法。 最后，公开了无线读出系统的详细和说明性示意图。

公开(公告)号：US08182890B2

公开(公告)日：2012-05-22

申请号：US12016085

申请日：2008-01-17

申请人： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

发明人： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

IPC分类号： B29D23/00 ,  A61F2/04

CPC分类号： A61L31/14 ,  A61F2/82 ,  A61F2/915 ,  A61F2002/825 ,  A61F2230/0013 ,  A61F2250/0036 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  Y10T428/13 ,  Y10T428/1352 ,  Y10T428/139 ,  C08L67/04

摘要： Biodegradable endoprostheses are formed from amorphous polymers having desirable biodegradation characteristics. The strength of such amorphous polymers is enhanced by annealing to increase crystallinity without substantially increasing the biodegradation time.

摘要翻译： 可生物降解的内用假体由具有理想的生物降解特性的无定形聚合物形成。 通过退火来提高这种无定形聚合物的强度以增加结晶度，而基本上不增加生物降解时间。

公开(公告)号：US20120093891A1

公开(公告)日：2012-04-19

申请号：US13333526

申请日：2011-12-21

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC分类号： A61K31/436 ,  A61K9/00 ,  A61F2/82 ,  A61M25/00 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P37/06 ,  A61M25/10 ,  C07D498/16 ,  A61F2/02 ,  B82Y5/00

CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: and salts, hydrates, isomers, metabolites and prodrugs thereof.

摘要翻译： 本发明提供包含药学上可接受的赋形剂和下式化合物的药物组合物：其中R 1，R 2，R 3，R 5，R 6和R 8各自独立地选自H，C 1-6烷基和OH ; R 4，R 7和R 9各自独立地选自C 1-6烷氧基和OH; R 10是选自H，-OH，-OP（O）Me 2，-O-（CH 2）n -OH和-O-（CH 2）m -O-（CH 2）o -CH 3的成员，其中 下标n和m各自独立地为2至8，下标o为1至6; L1和L4中的每一个独立地选自以下各项：L2和L3各自独立地选自：和其盐，水合物，异构体，代谢物和前药。

公开(公告)号：US08088789B2

公开(公告)日：2012-01-03

申请号：US12046024

申请日：2008-03-11

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC分类号： A61K31/427 ,  A61K31/4525 ,  A61K31/365 ,  A61K31/4353 ,  A61K31/436

CPC分类号： A61K31/436 ,  A61K9/0004 ,  A61K31/439 ,  A61K31/4525 ,  A61K45/06

摘要： A method of treating an ophthalmic condition or disease by administering a compound disclosed herein is provided. The compound can be administered systemically or locally and in a variety of ways, such as via a temporary device, an implant, an injection or an eye drop. The compound can also be administered with an additional therapeutic agent.

摘要翻译： 提供了通过施用本文公开的化合物治疗眼部疾病或疾病的方法。 化合物可以全身或局部地以各种方式施用，例如经由临时装置，植入物，注射剂或滴眼剂。 化合物也可以与另外的治疗剂一起施用。

公开(公告)号：US20090276392A1

公开(公告)日：2009-11-05

申请号：US12114458

申请日：2008-05-02

申请人： John Yan

发明人： John Yan

IPC分类号： G06N5/02

CPC分类号： G06F19/321 ,  G16H40/63

摘要： Certain embodiments of the present invention provide a method for configuring a medical imaging system, the method comprising: permitting a user to interact with a display protocol, said display protocol further comprising a plurality of rules; allowing said user to select a target rule from said plurality of rules; and facilitating said user to configure a condition for said target rule, wherein said display protocol is capable of a first execution when said condition is satisfied, and wherein the display protocol is capable of a second execution when said condition is not satisfied. In accordance with an embodiment, said condition further comprises at least one of: an entry condition and an exit condition.

摘要翻译： 本发明的某些实施例提供了一种用于配置医学成像系统的方法，所述方法包括：允许用户与显示协议交互，所述显示协议还包括多个规则; 允许所述用户从所述多个规则中选择目标规则; 并且便于所述用户配置所述目标规则的条件，其中当满足所述条件时，所述显示协议能够进行第一执行，并且其中当所述条件不满足时，所述显示协议能够进行第二执行。 根据一个实施例，所述条件还包括以下中的至少一个：入口条件和退出条件。

公开(公告)号：US20080138375A1

公开(公告)日：2008-06-12

申请号：US11854312

申请日：2007-09-12

申请人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

发明人： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC分类号： A61F2/02 ,  A61K31/4353 ,  C07D221/06 ,  A61P43/00

CPC分类号： A61K31/787 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61K2300/00

摘要： The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6 and R8 are each independently a member selected from the group consisting of H, C1-6 alkyl and OH; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o— CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: each of L2 and L3 are independently selected from the group consisting of: salts, hydrates, isomers, metabolites and prodrugs thereof.

摘要翻译： 本发明提供一种药物组合物，其包含药学上可接受的赋形剂和下式化合物：其中R 1，R 2，R 3， R 5，R 6和R 8各自独立地是选自H，C 1-6， 烷基和OH; R 4，R 7和R 9各自独立地选自C 1-6 - 烷氧基 和OH; R 10是选自H，-OH，-OP（O）Me 2，-O - （CH 2/2）， OH）和-O-（CH 2 CH 2）m -O - （CH 2 CH 2） 其中下标n和m各自独立地为2至8，下标o为1至6; L 1和L 4中的每一个独立地选自：L 2和L 3中的每一个， 独立地选自：其盐，水合物，异构体，代谢物和前药。

公开(公告)号：US20060246704A1

公开(公告)日：2006-11-02

申请号：US11116571

申请日：2005-04-27

申请人： John Yan ,  Yong Du ,  Bruce Symons

发明人： John Yan ,  Yong Du ,  Bruce Symons

IPC分类号： H01L21/44 ,  H01L21/00

CPC分类号： H01L25/50 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L25/0657 ,  H01L2224/05554 ,  H01L2224/32145 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/49175 ,  H01L2224/73265 ,  H01L2224/92247 ,  H01L2225/0651 ,  H01L2225/06555 ,  H01L2225/06575 ,  H01L2924/00014 ,  H01L2924/01006 ,  H01L2924/01023 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/01082 ,  H01L2924/01087 ,  H01L2924/014 ,  H01L2924/09701 ,  H01L2924/15311 ,  H01L2924/15787 ,  H01L2924/181 ,  H01L2924/3025 ,  H01L2924/00 ,  H01L2924/00012 ,  H01L2224/32225 ,  H01L2224/45099 ,  H01L2224/05599

摘要： A multi-chip module and a method for manufacturing the multi-chip module. A first semiconductor chip is mounted to a support substrate and a second semiconductor chip is mounted to the first semiconductor chip. The second semiconductor chip has a smaller dimension than the first semiconductor chip. A spacer is coupled to the second semiconductor chip. Bonding pads on the first and second semiconductor chips are wirebonded to bonding pads on the support substrate. A third semiconductor chip is mounted to the spacer and bonding pads on the third semiconductor chip are wirebonded to bonding pads on the support substrate.

摘要翻译： 一种多芯片模块及其制造方法。 第一半导体芯片安装在支撑基板上，第二半导体芯片安装在第一半导体芯片上。 第二半导体芯片的尺寸比第一半导体芯片小。 间隔件耦合到第二半导体芯片。 第一和第二半导体芯片上的接合焊盘被引线键合到支撑衬底上的接合焊盘。 第三半导体芯片安装到间隔件上，并且第三半导体芯片上的接合焊盘被引线接合到支撑衬底上的接合焊盘。

公开(公告)号：US20050209680A1

公开(公告)日：2005-09-22

申请号：US10880025

申请日：2004-06-28

申请人： David Gale ,  Bin Huang ,  John Capek ,  John Yan ,  Houdin Dehnad

发明人： David Gale ,  Bin Huang ,  John Capek ,  John Yan ,  Houdin Dehnad

IPC分类号： A61F2/82 ,  A61F2/92 ,  A61L31/14 ,  A61F2/06

CPC分类号： A61L31/148 ,  A61F2/0077 ,  A61F2/82 ,  A61F2/91 ,  A61F2/915 ,  A61F2/92 ,  A61F2002/91533 ,  A61F2002/91566 ,  A61F2002/91583 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2250/003 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/028 ,  A61L31/10 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/12 ,  Y10T29/49982

摘要： A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles.

摘要翻译： 这里描述了一种制造植入式医疗装置（例如支架）的装置和方法。 该装置包括由生物侵蚀金属组成的金属区域和由与金属区域接触的可生物降解的聚合物组成的聚合物区域。 当暴露于体液时，当暴露于体液时，金属区域可能以不同于聚合物区域的速度侵蚀。 在某些实施方案中，聚合物区域是外层，金属区域是该装置的内层。 本发明的另一方面包括装置和制造该装置的方法，该装置包括可生物降解的聚合物和可生物侵蚀的金属颗粒的混合物。 混合物可用于制造可植入医疗装置或涂覆可植入医疗装置。 在一些实施方案中，金属颗粒是金属纳米颗粒。

公开(公告)号：US20050203612A1

公开(公告)日：2005-09-15

申请号：US10607836

申请日：2003-06-27

申请人： Vinayak Bhat ,  John Yan

发明人： Vinayak Bhat ,  John Yan

IPC分类号： A61F2/00 ,  A61F2/90 ,  A61L27/54 ,  A61L31/16 ,  A61F2/06

CPC分类号： A61F2/90 ,  A61F2/91 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91533 ,  A61F2210/0076 ,  A61F2250/0067 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/416

摘要： Devices and methods for reducing, inhibiting, or treating restenosis and hyperplasia after intravascular intervention are provided. In particular, the present invention provides luminal prostheses which allow for sustained or controlled release of at least one therapeutic capable agent with increased efficacy to selected locations within a patient's vasculature to reduce restenosis. An intraluminal prosthesis may comprise an expandable structure and a source adjacent the expandable structure for releasing the therapeutic capable agent into a body lumen to reduce smooth muscle cell proliferation.