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公开(公告)号:US06265416B1
公开(公告)日:2001-07-24
申请号:US09429424
申请日:1999-10-28
申请人: Jolie Anne Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
发明人: Jolie Anne Bastian , Matthew Joseph Fisher , Richard Waltz Harper , Ho-Shen Lin , Jefferson Ray McCowan , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Michael Robert Wiley , Minsheng Zhang
IPC分类号: A61K31535
CPC分类号: C07D471/04
摘要: This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.
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公开(公告)号:US6025382A
公开(公告)日:2000-02-15
申请号:US846647
申请日:1997-04-30
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译: 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂,凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物,其制备方法和中间体,以及包含式I化合物的药物制剂。
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公开(公告)号:US06251921B1
公开(公告)日:2001-06-26
申请号:US09312593
申请日:1999-05-14
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: A61K314436
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号:US06177440B1
公开(公告)日:2001-01-23
申请号:US09063066
申请日:1998-04-21
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: A61K3144
CPC分类号: C07D209/88
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号:US06713645B1
公开(公告)日:2004-03-30
申请号:US09688106
申请日:2000-10-13
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: C07C6976
CPC分类号: C07D409/04 , C07D209/88 , C07F9/5728
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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公开(公告)号:US06620837B1
公开(公告)日:2003-09-16
申请号:US10111508
申请日:2002-04-23
IPC分类号: A61K3140
CPC分类号: C07D409/10 , C07D333/16 , C07D333/24 , C07D409/12
摘要: This application relates to novel compounds of formula (I) (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula (I), and the use of defined compounds of formula (I) as thrombin inhibitors.
摘要翻译: 本申请涉及本文定义的式(I)(及其药学上可接受的盐),其制备方法和中间体的新型化合物,其包含式(I)的新化合物的药物制剂,以及定义的式 (I)作为凝血酶抑制剂。
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7.Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders 失效
标题翻译: 某些甘氨酸衍生物作为用于治疗血栓形成障碍的因子Xa抑制剂公开(公告)号:US07078415B2
公开(公告)日:2006-07-18
申请号:US10496020
申请日:2002-12-09
申请人: Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
发明人: Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
IPC分类号: A61K31/4375 , A61K31/435 , C07D211/10
CPC分类号: C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要: Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译: 其中R,R 1,R 2,n和X 1具有本说明书中给出的含义的式(I)化合物是因子 可用于治疗血栓形成障碍的Xa抑制剂。
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8.Certain glycine derivatives as factor Xa inhibitors for use in the treatment of thrombotic disorders 失效
标题翻译: 某些甘氨酸衍生物作为用于治疗血栓形成障碍的因子Xa抑制剂公开(公告)号:US07297706B2
公开(公告)日:2007-11-20
申请号:US11456589
申请日:2006-07-11
申请人: Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
发明人: Michael Robert Wiley , Daniel Jon Sall , Christopher William Murray , Stephen Clinton Young , Jolie Anne Bastian
IPC分类号: A61K31/4375 , A61K31/435 , C07D211/10
CPC分类号: C07D401/14 , C07D211/26 , C07D211/58 , C07D401/04 , C07D401/12 , C07D409/12 , C07D409/14
摘要: Compounds of formula (I) in which R, R1, R2, n and X1 have the meanings given in the specification are Factor Xa inhibitors useful in the treatment of thrombotic disorders.
摘要翻译: 其中R,R 1,R 2,n和X 1具有本说明书中给出的含义的式(I)化合物是因子 可用于治疗血栓形成障碍的Xa抑制剂。
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公开(公告)号:US07241772B2
公开(公告)日:2007-07-10
申请号:US11276201
申请日:2006-02-17
IPC分类号: A61K31/44 , C07D471/04
CPC分类号: C07D409/12 , C07D471/04
摘要: The present invention relates to 2-imidazo[1,5-a]pyridine containing β3 adrenergic receptor agonists or pharmaceutical salts thereof.
摘要翻译: 本发明涉及含有β-3肾上腺素能受体激动剂的2-咪唑并[1,5-a]吡啶或其药物盐。
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公开(公告)号:US07208505B2
公开(公告)日:2007-04-24
申请号:US10486867
申请日:2002-08-06
申请人: Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
发明人: Daniel Jon Sall , Jolie Anne Bastian , Rushad Eruch Karanjawala , Cynthia Darshini Jesudason , Theo Schotten , Britta Evers , Gerd Reuhter , Don Richard Finley , Freddie Craig Stevens , Vincent Patrick Rocco , Patrick Gianpietro Spinazze , John Xiaoqiang He , John Arnold Werner , William George Trankle , Andrew Michael Ratz
IPC分类号: C07D209/14 , C07D213/64 , A61K31/404 , A61K31/422 , A61K31/444
CPC分类号: C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要: The present invention relates to a β3 adrenergic receptor agonist of formula (I); or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful, e.g., for treating Type 2 diabetes and/or obesity
摘要翻译: 本发明涉及式(I)的β3肾上腺素能受体激动剂; 或其药学盐; 其能够增加细胞中的脂肪分解和能量消耗,因此可用于例如治疗2型糖尿病和/或肥胖症
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