-
公开(公告)号：US06251921B1
公开(公告)日：2001-06-26
申请号：US09312593
申请日：1999-05-14
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： A61K314436
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
-
公开(公告)号：US6025382A
公开(公告)日：2000-02-15
申请号：US846647
申请日：1997-04-30
申请人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人： Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号： C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要： This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译： 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂，凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物，其制备方法和中间体，以及包含式I化合物的药物制剂。
-
公开(公告)号：US06593345B1
公开(公告)日：2003-07-15
申请号：US08921625
申请日：1997-08-27
IPC分类号： A61K31535
CPC分类号： C07D295/088 , C07C41/26 , C07C41/28 , C07C43/23 , C07C43/295 , C07C45/46 , C07C45/71 , C07C47/575 , C07C49/755 , C07C51/367 , C07C67/03 , C07C67/11 , C07C67/293 , C07C67/317 , C07C69/017 , Y02P20/55 , C07C59/68 , C07C69/18
摘要： The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
摘要翻译： 本发明提供新的取代的萘基化合物，中间体，组合物，药物制剂和使用方法。
-
公开(公告)号：US5985898A
公开(公告)日：1999-11-16
申请号：US97810
申请日：1998-06-16
申请人： Alan David Palkowitz
发明人： Alan David Palkowitz
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , A61K31/445
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof.
-
公开(公告)号：US5856339A
公开(公告)日：1999-01-05
申请号：US552679
申请日：1995-11-03
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , A61K31/445 , C07D409/12
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： The present invention provides intermediate compounds and processes for the preparation of compounds of formula I ##STR1## wherein R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供中间体化合物及其制备方法，其中R 1a为-H或-OR 7a，其中R 7a为-H或羟基保护基; R2a是-H，卤素或-OR8a，其中R8a是-H或羟基保护基; R3是1-哌啶基，1-吡咯烷子基，甲基-1-吡咯烷基，二甲基-1-吡咯烷子基，4-吗啉代，二甲基氨基，二乙基氨基，二异丙基氨基或1-六亚甲基亚氨基; n为2或3; Z为-O-或-S-; 或其药学上可接受的盐。
-
6.发明授权Benzothiophene compounds, intermediates, processes, compositions, and methods 失效苯并噻吩化合物，中间体，方法，组合物和方法
公开(公告)号：US6075151A
公开(公告)日：2000-06-13
申请号：US138789
申请日：1998-08-24
IPC分类号： A61K31/38 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4433 , A61K31/445 , A61K31/4535 , A61K31/535 , A61K31/55 , A61P3/06 , A61P9/00 , A61P15/08 , A61P19/10 , A61P43/00 , C07D333/66 , C07D409/12 , C07D333/72
CPC分类号： C07D333/66
摘要： The invention provides benzothiophene compounds, formulations, and methods of inhibiting bone loss or bone resorption, particularly osteoporosis, and cardiovascular-related pathological conditions, including hyperlipidemia, and other cardiovascular pathologies.
摘要翻译： 本发明提供苯并噻吩化合物，制剂和抑制骨丢失或骨吸收，特别是骨质疏松症的心血管相关病理状况，包括高脂血症和其它心血管病变的方法。
-
公开(公告)号：US5986109A
公开(公告)日：1999-11-16
申请号：US100179
申请日：1998-06-18
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , C07D333/56
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/5355 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , Y02P20/55
摘要： A compound of fomula XIV: ##STR1## wherein: R.sup.1a is --H or --OR.sup.7a in which R.sup.7a is a hydoxy protecting group;R.sup.2a is --H, halo, or OR.sup.8a in which R.sup.8a is a hydroxy protecting group; andR.sup.9 is a leaving group;or a pharmaceutically acceptable salt thereof
摘要翻译： 化合物XIV：其中：R 1a是-H或-OR 7a，其中R 7a是羟基保护基; R2a是-H，卤素或OR8a，其中R8a是羟基保护基; R9为离去基团; 或其药学上可接受的盐
-
公开(公告)号：US5977093A
公开(公告)日：1999-11-02
申请号：US552565
申请日：1995-11-03
申请人： Alan David Palkowitz
发明人： Alan David Palkowitz
IPC分类号： A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/62 , C07D333/64 , A61K31/56 , A61K31/445 , C07D409/12
CPC分类号： C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4535 , A61K31/55 , A61K31/57 , C07D333/64 , Y02P20/55
摘要： A method for alleviating the symptoms of post-menopausal syndrome comprising administering to a woman in need thereof an effective amount of a compound of formula I whereinR.sup.1a is --H or --OR.sup.7a in which R.sup.7a is --H or a hydroxy protecting group;R.sup.2a is --H, halo, or --OR.sup.8a in which R.sup.8a is --H or a hydroxy protecting group;R.sup.3 is 1-piperidinyl, 1-pyrrolidino, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidino, 4-morpholino, dimethylamino, diethylamino, diisopropylamino, or 1-hexamethyleneimino;n is 2 or 3; andZ is --O-- or --S--;or a pharmaceutically acceptable salt thereof, and further comprising administering to said woman an effective amount of progestin.
摘要翻译： 一种减轻绝经后综合症状的方法，包括向有需要的妇女施用有效量的式Ⅰ化合物，其中R 1a为-H或-OR 7a，其中R 7a为-H或羟基保护基; R2a是-H，卤素或-OR8a，其中R8a是-H或羟基保护基; R3是1-哌啶基，1-吡咯烷子基，甲基-1-吡咯烷基，二甲基-1-吡咯烷子基，4-吗啉代，二甲基氨基，二乙基氨基，二异丙基氨基或1-六亚甲基亚氨基; n为2或3; Z为-O-或-S-; 或其药学上可接受的盐，并且还包括向所述妇女施用有效量的孕激素。
-
9.发明授权1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods 失效1-芳氧基-2-芳基萘基化合物，中间体，组合物和方法
公开(公告)号：US5916916A
公开(公告)日：1999-06-29
申请号：US939575
申请日：1997-09-29
IPC分类号： C07D295/08 , A61K31/19 , A61K31/215 , A61K31/40 , A61K31/445 , A61P43/00 , C07C45/46 , C07C45/71 , C07C47/575 , C07C59/64 , C07C59/66 , C07C59/68 , C07C69/734 , C07C69/736 , C07D211/14 , C07D295/096 , C07D295/18 , C07D295/185 , A01N37/00 , A01N37/10 , A01N43/40 , C07C69/76
CPC分类号： C07D295/185 , C07C45/46 , C07C45/71 , C07C47/575 , C07C59/64 , C07C59/68 , C07C69/736 , C07D295/096
摘要： The instant invention provides a series of naphthyl compounds having an oxygen linker at the 1-position which are useful as selective estrogen receptor modulators.
摘要翻译： 本发明提供一系列具有1位氧连接体的萘基化合物，其可用作选择性雌激素受体调节剂。
-
公开(公告)号：US5731342A
公开(公告)日：1998-03-24
申请号：US787041
申请日：1997-01-27
IPC分类号： A61K20060101 , C07D20060101 , C07D333/56 , C07D333/64 , A61K31/38
CPC分类号： C07D333/56 , C07D333/64
摘要： This invention provides novel benzothiophene compounds.
摘要翻译： 本发明提供新的苯并噻吩化合物。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.07 秒)