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公开(公告)号:US06251921B1
公开(公告)日:2001-06-26
申请号:US09312593
申请日:1999-05-14
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: A61K314436
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号:US6025382A
公开(公告)日:2000-02-15
申请号:US846647
申请日:1997-04-30
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: C07D295/08 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4436 , A61K31/4439 , A61K31/4453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , A61P7/02 , C07D333/56 , C07D333/58 , C07D333/62 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/10 , C07D409/12 , C07D413/06 , C07D521/00 , A61K31/40 , A61K31/38 , C07D409/14
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
摘要翻译: 本申请涉及作为本文定义的式I二胺的凝血酶抑制剂,凝血抑制剂和血栓栓塞障碍剂的用途。 它还提供式I的新型化合物,其制备方法和中间体,以及包含式I化合物的药物制剂。
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