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1.发明申请Compositions and methods for enhancing drug delivery across and into epithelial tissues 审中-公开用于增强穿过和进入上皮组织的药物递送的组合物和方法公开(公告)号：US20070173436A1
公开(公告)日：2007-07-26
申请号：US11542278
申请日：2006-10-02
CPC分类号： A61K31/337 , A61K31/155 , A61K31/436 , A61K31/496 , A61K31/573 , A61K38/00 , A61K38/13 , A61K47/54 , A61K47/55 , A61K47/555 , A61K47/557 , A61K47/62 , A61K47/64 , A61K47/645 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/146 , B82Y5/00 , C07K7/06 , C07K7/64
摘要： This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
摘要翻译： 本发明提供用于增强药物和其它药物穿过上皮组织包括皮肤，胃肠道，肺上皮，眼组织等的递送的组合物和方法。 组合物和方法也可用于穿过内皮组织，包括血脑屏障。 与非共轭化合物相比，组合物和方法使用具有足够的胍基或脒基侧链部分的递送增强转运蛋白，以增强与试剂缀合的化合物跨越组织的一个或多个层的递送。 递送增强聚合物包括例如优选长度在约6和25个残基之间的聚精氨酸分子。
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2.发明申请Methods and compositions for enhancing transport across biological membranes 审中-公开用于增强跨生物膜的转运的方法和组合物公开(公告)号：US20060111274A1
公开(公告)日：2006-05-25
申请号：US11335007
申请日：2006-01-18
申请人： Jonathan Rothbard , Paul Wender
发明人： Jonathan Rothbard , Paul Wender
IPC分类号： A61K48/00 , A61K38/17 , A61K31/785
CPC分类号： C07D305/14 , A61K31/785 , A61K47/62 , A61K47/645 , A61K48/00 , C07B2200/11 , C40B40/00
摘要： Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention pertains to a method for enhancing transport of a selected compound across a biological membrane, wherein a biological membrane is contacted with a conjugate containing a biologically active agent that is covalently attached to a transport polymer. In a preferred embodiment, the polymer consists of from 6 to 25 subunits, at least 50% of which contain a guanidino or amidino sidechain moiety. The polymer is effective to impart to the attached agent a rate of trans-membrane transport across a biological membrane that is greater than the rate of trans-membrane transport of the agent in non-conjugated form.
摘要翻译： 公开了在生物膜上运输药物和大分子的方法和组合物。 在一个实施方案中，本发明涉及一种用于增强所选化合物跨生物膜的转运的方法，其中生物膜与含有共价连接于转运聚合物的生物活性剂的缀合物接触。 在优选的实施方案中，聚合物由6至25个亚基组成，其中至少50％含有胍基或脒基侧链部分。 聚合物有效地赋予附着剂超过生物膜的跨膜转运速率，该速率大于非共轭形式的试剂的跨膜转运速率。
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3.发明申请Compositions and methods for enhancing drug delivery across and into ocular tissues 失效用于增强穿过和进入眼组织的药物递送的组合物和方法公开(公告)号：US20070213277A1
公开(公告)日：2007-09-13
申请号：US11800358
申请日：2007-05-04
IPC分类号： A61K31/155
CPC分类号： A61K9/0048 , A61K31/155 , A61K38/00 , A61K47/54 , A61K47/55 , A61K47/555 , A61K47/557 , A61K47/62 , A61K47/64 , A61K47/645 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/146 , B82Y5/00 , C07K7/06 , C07K7/64
摘要： This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including into and across ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
摘要翻译： 本发明提供用于增强药物和其它药物穿过上皮组织递送的组合物和方法，包括进入和穿过眼组织等。 组合物和方法也可用于跨内皮组织递送，包括血脑屏障。 与非共轭化合物相比，组合物和方法使用具有足够的胍基或脒基侧链部分的递送增强转运蛋白，以增强与试剂缀合的化合物跨越组织的一个或多个层的递送。 递送增强聚合物包括例如优选长度在约6和25个残基之间的聚精氨酸分子。
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4.发明授权公开(公告)号：US08097269B2
公开(公告)日：2012-01-17
申请号：US11463237
申请日：2006-08-08
IPC分类号： A61F2/02
CPC分类号： A61L31/088 , A61L27/306 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/608 , C08L83/04
摘要： Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
摘要翻译： 公开了使用用作生物活性材料储存器的溶胶 - 凝胶组合物涂层的植入式医疗装置，以及使用溶胶 - 凝胶组合物涂层来改善有机和无机基材的粘附性。
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公开(公告)号：US4584195A
公开(公告)日：1986-04-22
申请号：US623178
申请日：1984-06-21
IPC分类号： C12N15/09 , A61K39/095 , A61K39/385 , C07K7/06 , C07K7/08 , C07K14/195 , C07K14/22 , C07K14/41 , C07K19/00 , A61K39/02 , A61K37/02 , C07K7/00
CPC分类号： C07K14/22 , A61K39/385 , A61K2039/6081 , Y10S530/806
摘要： Vaccines comprising peptide sequences corresponding to immunorecessive determinants in gonorrhea pilus protein are disclosed. The vaccines are effective in protecting human subjects against infection by a wide range of gonorrhea strains by raising antibodies which interfere with the colonization of the epithelium by the infecting bacteria.
摘要翻译： 公开了包含对应于淋病性真菌蛋白中的免疫进化决定簇的肽序列的疫苗。 疫苗通过产生通过感染细菌干扰上皮细胞定植的抗体，有效地保护人类受体免受广泛淋病菌株的感染。
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6.发明授权公开(公告)号：US10034915B2
公开(公告)日：2018-07-31
申请号：US13531114
申请日：2012-06-22
CPC分类号： A61K38/17 , A61K39/44 , C07K7/08 , C07K14/47 , C07K2319/30
摘要： The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of specific peptides derived from HSPB5, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease.
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7.发明申请Small Heat Shock Proteins and Active Fragments Thereof as a Therapy for Inflammation and Ischemia 审中-公开小热休克蛋白及其活性片段作为炎症和局部缺血治疗公开(公告)号：US20130071392A1
公开(公告)日：2013-03-21
申请号：US13531114
申请日：2012-06-22
CPC分类号： A61K38/17 , A61K39/44 , C07K7/08 , C07K14/47 , C07K2319/30
摘要： The invention provides methods for treating inflammatory diseases by administering to the subject an effective amount of an agent that provides small heat shock protein activity, where the dose is effective to suppress or prevent initiation, progression, or relapses of disease, including the progression of established disease.
摘要翻译： 本发明提供了治疗炎性疾病的方法，其通过向受试者施用有效量的提供小的热休克蛋白活性的药剂，其中该剂量有效地抑制或预防疾病的起始，进展或复发，包括建立的 疾病。
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公开(公告)号：US20050192210A1
公开(公告)日：2005-09-01
申请号：US11070528
申请日：2005-03-01
申请人： Jonathan Rothbard , Paul McGrane , Edgar Engleman , C. Fathman , Erik Kreider
发明人： Jonathan Rothbard , Paul McGrane , Edgar Engleman , C. Fathman , Erik Kreider
IPC分类号： A61K31/137 , A61K31/4178 , A61K31/5377 , A61K38/00 , A61K38/08
CPC分类号： A61K38/08 , A61K31/137 , A61K31/4178 , A61K31/5377 , A61K38/04
摘要： This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud's syndrome, heparin overdose, vulvodynia, and wound healing. The invention also provides arginine polymers and arginine homopolymers for use in organ perfusate and preservation solutions.
摘要翻译： 本发明涉及用于治疗血管病症的组合物和方法。 本发明提供精氨酸聚合物和精氨酸均聚物，用于治疗和/或预防青光眼，肺动脉高压，哮喘，慢性阻塞性肺病，勃起功能障碍，雷诺综合征，肝素过量，外阴和伤口愈合。 本发明还提供用于器官灌注液和保存溶液的精氨酸聚合物和精氨酸均聚物。
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公开(公告)号：US20070185203A1
公开(公告)日：2007-08-09
申请号：US11736689
申请日：2007-04-18
申请人： Jonathan Rothbard , Paul McGrane , Edgar Engleman , C. Fathman , Erik Kreider
发明人： Jonathan Rothbard , Paul McGrane , Edgar Engleman , C. Fathman , Erik Kreider
IPC分类号： A61K31/195
CPC分类号： A61K38/08 , A61K31/137 , A61K31/4178 , A61K31/5377 , A61K38/04
摘要： This invention relates to compositions and methods for treatment of vascular conditions. The invention provides arginine polymers and arginine homopolymers for the treatment and/or prevention of glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud's syndrome, heparin overdose, vulvodynia, and wound healing. The invention also provides arginine polymers and arginine homopolymers for use in organ perfusate and preservation solutions.
摘要翻译： 本发明涉及用于治疗血管病症的组合物和方法。 本发明提供精氨酸聚合物和精氨酸均聚物，用于治疗和/或预防青光眼，肺动脉高压，哮喘，慢性阻塞性肺病，勃起功能障碍，雷诺综合征，肝素过量，外阴和伤口愈合。 本发明还提供用于器官灌注液和保存溶液的精氨酸聚合物和精氨酸均聚物。
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10.发明申请公开(公告)号：US20070071789A1
公开(公告)日：2007-03-29
申请号：US11463237
申请日：2006-08-08
IPC分类号： A61K9/14
CPC分类号： A61L31/088 , A61L27/306 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/608 , C08L83/04
摘要： Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
摘要翻译： 公开了使用用作生物活性材料储存器的溶胶 - 凝胶组合物涂层的植入式医疗装置，以及使用溶胶 - 凝胶组合物涂层来改善有机和无机基材的粘附性。
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