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    Methods of using new thieno-triazole-1,4-diazepino-2-carboxylic acid amides
    1.
    发明授权
    Methods of using new thieno-triazole-1,4-diazepino-2-carboxylic acid amides 失效
    使用新的噻吩并三唑-1,4-二氮杂-2-羧酸酰胺的方法

    公开(公告)号：US5155103A

    公开(公告)日：1992-10-13

    申请号：US774683

    申请日：1991-10-11

    申请人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

    发明人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge Casals-Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

    IPC分类号： A61K31/55 ,  A61K31/5517 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07C235/40 ,  C07D243/00 ,  C07D249/08 ,  C07D333/00 ,  C07D333/36 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14

    CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D495/14

    摘要： The invention relates to new thieno-triazolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

    摘要翻译： 本发明涉及式I的新的噻吩并三唑并-1,4-二氮杂-2-羧酸酰胺其中R 1表示氢，可以任意被C 1 -C 4直链或支链烷基取代的C 1 -C 4直链或支链烷基 卤素，优选Cl或Br，或羟基，环丙基，C 1 -C 3烷氧基，优选甲氧基或卤素，优选氯或溴; R2和R3各自独立地代表氢，C1-C4直链或支链烷基，C1-C4羟基烷基或两个R2和R3与氮原子一起表示5-，6-或7-元环，其中 任选地含有氮，氧或硫原子作为另外的杂原子，第二氮原子任选被C 1 -C 4烷基，优选甲基取代; R4表示α-吡啶基或苯基，其中苯环优选在2-位上被甲基，卤素，优选氯或溴，硝基或三氟甲基取代; n表示数字0,1,2,3,4,5,6,7或8中的一个; 及其新型中间体。 式I化合物可用于治疗涉及血小板活化因子的病理状况和疾病。

    Thieno-traizolo-1,4-diazepino-2-carboxylic acid amides
    8.
    发明授权
    Thieno-traizolo-1,4-diazepino-2-carboxylic acid amides 失效
    噻吩并[1,4-diazepino-2-carboxylic acid amides]

    公开(公告)号：US4968794A

    公开(公告)日：1990-11-06

    申请号：US252725

    申请日：1988-10-03

    申请人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge C. Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

    发明人： Karl-Heinz Weber ,  Albrecht Harreus ,  Jorge C. Stenzel ,  Gojko Muacevic ,  Wolfgang Troger ,  Gerhard Walther

    IPC分类号： A61K31/55 ,  A61K31/5517 ,  A61P7/02 ,  A61P9/02 ,  A61P11/08 ,  A61P29/00 ,  A61P37/00 ,  A61P37/08 ,  C07C235/40 ,  C07D243/00 ,  C07D249/08 ,  C07D333/00 ,  C07D333/36 ,  C07D495/00 ,  C07D495/04 ,  C07D495/14

    CPC分类号： C07D495/04 ,  C07D333/36 ,  C07D495/14

    摘要： The invention relates to new thieno-traizolo-1,4-diazepino-2-carboxylic acid amides of formula I ##STR1## wherein R.sub.1 represents hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl which can optionally be substituted by halogen, preferably Cl or Br, or by hydroxy, cyclopropyl, C.sub.1 -C.sub.3 alkoxy, preferably methoxy, or halogen, preferably chlorine or bromine;R.sub.2 and R.sub.3, each independently, represent hydrogen, a C.sub.1 -C.sub.4 straight-chained or branched alkyl, C.sub.1 -C.sub.4 hydroxyalkyl or the two groups R.sub.2 and R.sub.3 together with the nitrogen atom represent a 5-, 6- or 7-membered ring which optionally contains a nitrogen, oxygen or sulfur atom as a further heteroatom, the second nitrogen atom optionally being substituted by a C.sub.1 -C.sub.4 alkyl, preferably a methyl group;R.sub.4 represents alpha-pyridyl or a phenyl in which the phenyl ring can be substituted preferably in the 2-position, by methyl, halogen, preferably chlorine or bromine, nitro or trifluoromethyl;n represents one of the numbers 0, 1, 2, 3, 4, 5, 6, 7 or 8; and novel intermediates therefor.The compounds of formula I are useful in the treatment of pathological conditions and diseases in which platelet activating factor is implicated.

    摘要翻译： 本发明涉及式I的新的噻吩并[1,3-diazepino-2-carboxylic acid amides]（Ⅰ），其中R1代表氢，C1-C4直链或支链烷基，其可以任选地被 卤素，优选Cl或Br，或羟基，环丙基，C 1 -C 3烷氧基，优选甲氧基或卤素，优选氯或溴; R2和R3各自独立地代表氢，C1-C4直链或支链烷基，C1-C4羟基烷基或两个R2和R3与氮原子一起表示5-，6-或7-元环，其中 任选地含有氮，氧或硫原子作为另外的杂原子，第二氮原子任选被C 1 -C 4烷基，优选甲基取代; R4表示α-吡啶基或苯基，其中苯环优选在2-位上被甲基，卤素，优选氯或溴，硝基或三氟甲基取代; n表示数字0,1,2,3,4,5,6,7或8中的一个; 及其新型中间体。 式I化合物可用于治疗涉及血小板活化因子的病理状况和疾病。