公开(公告)号：US20080255075A1

公开(公告)日：2008-10-16

申请号：US11947025

申请日：2007-11-29

申请人： Josef MESSINGER ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Mikko Unkila

发明人： Josef MESSINGER ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Mikko Unkila

IPC分类号： A61K31/58 ,  C07J43/00 ,  A61P35/00

CPC分类号： C07J43/00

摘要： Substituted estratriene compounds of formula (I) useful in therapy, especially in the treatment or inhibition of a steroid hormone dependent disorder requiring the inhibition of a 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1, type 2 and/or type 3 enzyme, as well as their salts, pharmaceutical compositions containing such compounds and processes for preparing such compounds.

摘要翻译： 可用于治疗，特别是治疗或抑制需要抑制17β-羟类固醇脱氢酶（17β-HSD）1型，2型和/或3型酶的类固醇激素依赖性病症的式（I）化合物的取代雌三烯化合物， 以及它们的盐，含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US08288367B2

公开(公告)日：2012-10-16

申请号：US11947025

申请日：2007-11-29

申请人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Mikko Unkila

发明人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Mikko Unkila

IPC分类号： A61K31/56 ,  C07J1/00

CPC分类号： C07J43/00

摘要： Substituted estratriene compounds of formula (I) useful in therapy, especially in the treatment or inhibition of a steroid hormone dependent disorder requiring the inhibition of a 17β-hydroxysteroid dehydrogenase (17β-HSD) type 1, type 2 and/or type 3 enzyme, as well as their salts, pharmaceutical compositions containing such compounds and processes for preparing such compounds.

摘要翻译： 用于治疗的式（I）的取代的雌三烯化合物，特别是用于治疗或抑制需要抑制17型和/ 酶及其盐，含有这些化合物的药物组合物和制备这些化合物的方法。

公开(公告)号：US20080146531A1

公开(公告)日：2008-06-19

申请号：US11856768

申请日：2007-09-18

申请人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Lila KALLIO nee Pirkkala

发明人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Lila KALLIO nee Pirkkala

IPC分类号： A61K31/58 ,  C07J43/00 ,  A61P35/00 ,  A61P25/00 ,  A61P13/00 ,  A61P3/00 ,  A61P17/00

CPC分类号： C07J43/00 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/863 ,  Y10S514/866 ,  Y10S514/903

摘要： Estratrien-triazoles corresponding to formula (I) (shown below) which are useful in therapy, especially for the treatment and/or prevention or inhibition of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17β-hydroxysteroid dehydrogenase (17β-HSD) such as 17β-HSD type 1, type 2 or type 3 enzyme.

摘要翻译： 对应于式（I）（如下所示）的依那他三唑可用于治疗，特别是用于治疗和/或预防或抑制类固醇激素依赖性病症，优选需要抑制17β的类固醇激素依赖性疾病或病症 - 类固醇脱氢酶（17β-HSD），如17β-HSD 1型，2型或3型酶。

公开(公告)号：US08080540B2

公开(公告)日：2011-12-20

申请号：US11856768

申请日：2007-09-18

申请人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Lila Kallio nee Pirkkala

发明人： Josef Messinger ,  Uwe Schoen ,  Heinrich-Hubert Thole ,  Bettina Husen ,  Pasi Koskimies ,  Lila Kallio nee Pirkkala

IPC分类号： A61K31/58 ,  C07J43/00

CPC分类号： C07J43/00 ,  Y10S514/825 ,  Y10S514/826 ,  Y10S514/863 ,  Y10S514/866 ,  Y10S514/903

摘要： Estratrien-triazoles corresponding to formula (I) (shown below) which are useful in therapy, especially for the treatment and/or prevention or inhibition of a steroid hormone dependent disorder, preferably a steroid hormone dependent disease or disorder requiring the inhibition of a 17β-hydroxysteroid dehydrogenase (17β-HSD) such as 17β-HSD type 1, type 2 or type 3 enzyme.

摘要翻译： 对应于式（I）（如下所示）的Estratrien-triazoles，其可用于治疗，特别是用于治疗和/或预防或抑制类固醇激素依赖性病症，优选类固醇激素依赖性疾病或病症，其需要抑制17＆bgr ; - 类固醇脱氢酶（17＆bgr; -HSD），如17＆bgr-HSD 1型，2型或3型酶。

公开(公告)号：US06602880B2

公开(公告)日：2003-08-05

申请号：US10183038

申请日：2002-06-27

申请人： Uwe Schoen ,  Josef Messinger ,  Reinhard Brueckner ,  Dieter Ziegler

发明人： Uwe Schoen ,  Josef Messinger ,  Reinhard Brueckner ,  Dieter Ziegler

IPC分类号： A61K3144

CPC分类号： C07D471/08 ,  C07D471/10

摘要： Pharmacologically active compounds of the general formula I wherein R1 is an alkyl group with 1-6 carbon atoms or a cycloalkylalkyl group with 4-7 carbon atoms, R2 is lower alkyl, and R3 is lower alkyl, or R2 and R3 together form an alkylene chain with 3-6 carbon atoms, and R4 represents a phenyl radical monosubstituted in the ortho or para position by nitro, cyano or lower alkanoyl or disubstituted in the ortho and para positions by nitro, and their physiologically compatible acid addition salts are described.

摘要翻译： 通式I的药理活性化合物，其中R1是具有1-6个碳原子的烷基或具有4-7个碳原子的环烷基烷基，R2是低级烷基，R3是低级烷基，或R2和R3一起形成亚烷基链， 6个碳原子，R 4表示在邻位或对位上由硝基，氰基或低级烷酰基单取代或在邻位和对位被二取代的苯基，硝基，其生理上相容的酸加成盐被描述。

公开(公告)号：US20110219788A1

公开(公告)日：2011-09-15

申请号：US13129870

申请日：2009-11-09

申请人： Heiko Zimmermann ,  Uwe Schoen ,  Guenter R. Fuhr ,  Dirk Leuthold ,  Marianne Belke

发明人： Heiko Zimmermann ,  Uwe Schoen ,  Guenter R. Fuhr ,  Dirk Leuthold ,  Marianne Belke

IPC分类号： F25D13/06 ,  F25B49/00

CPC分类号： A01N1/0252 ,  F25B2700/04 ,  F25D3/102 ,  F25D3/11 ,  F25D29/001 ,  F25D2600/02 ,  F25D2700/12 ,  F25D2700/16 ,  G01N1/42 ,  G01N2035/00435

摘要： The invention relates to a cryogenic storage device and to a method for operating a cryogenic storage device, particularly for cryogenic storage of biological samples, comprising a sample carrying device that is set up to accommodate samples, a cryogenic container that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container can be cooled, an intermediate storage container that is set up for intermediate storage of the sample carrying device, a transport device with which the sample carrying device can be moved between the cryogenic container and the intermediate storage container and a sensor device with which at least one operating parameter of the cryogenic storage device can be registered. The transport device is set up to be activated in dependence on an output signal from the sensor device upon registering a predetermined operating condition of the cryogenic storage device, so that the sample carrying device is moved from the cryogenic container to the intermediate storage container. Additionally or alternatively, an intermediate storage cooling device that is set up for cooling the intermediate storage container can be activated in dependence on an output signal of the sensor device.

摘要翻译： 本发明涉及一种低温存储装置和一种用于操作低温存储装置的方法，特别是用于生物样品的低温储存的方法，包括设置用于容纳样品的样品携带装置，设置为容纳 样品运送装置，用于冷冻低温容器的容器冷却装置，设置用于样品运送装置的中间储存的中间储存容器，运送装置，使样品运送装置能够在低温容器 以及可以登记低温储存装置的至少一个操作参数的中间储存容器和传感器装置。 传送装置被设置为在登记低温存储装置的预定操作条件时依赖于来自传感器装置的输出信号被激活，使得样品携带装置从低温容器移动到中间储存容器。 另外或替代地，可以根据传感器装置的输出信号激活设置用于冷却中间存储容器的中间存储冷却装置。

公开(公告)号：US06407106B1

公开(公告)日：2002-06-18

申请号：US09915558

申请日：2001-07-27

申请人： Daniel Jasserand ,  Uwe Schoen ,  Holger Sann ,  Reinhard Brueckner ,  Christian Eeckhout

发明人： Daniel Jasserand ,  Uwe Schoen ,  Holger Sann ,  Reinhard Brueckner ,  Christian Eeckhout

IPC分类号： A61K315377

CPC分类号： C07D403/06 ,  C07D403/14

摘要： N-triazolylmethyl-piperazine compounds which exhibit neurokinin receptor antagonistic activity corresponding to the formula I: wherein R1, R2 and R3 have the meanings given in the specification; pharmaceutical compositions containing these compounds; a process for preparing these compounds, and intermediate products of this process.

摘要翻译： 表现出对应于式I的神经激肽受体拮抗活性的N-三唑基甲基 - 哌嗪化合物：其中R1，R2和R3具有说明书中给出的含义; 含有这些化合物的药物组合物; 制备这些化合物的方法，以及该方法的中间产物。

公开(公告)号：US06291698B1

公开(公告)日：2001-09-18

申请号：US09556403

申请日：2000-04-24

申请人： Stefan Bade ,  Bernt Kesper ,  Robert Koell ,  Hartwig Rauleder ,  Uwe Schoen

发明人： Stefan Bade ,  Bernt Kesper ,  Robert Koell ,  Hartwig Rauleder ,  Uwe Schoen

IPC分类号： C07F708

CPC分类号： C07F7/122

摘要： The invention relates to a process for preparing vinyl chlorosilanes, that includes thermally and non-catalytically reacting chlorosilane with vinyl chloride at a temperature of 550 to 700° C. by flowing the chlorosilane and vinyl chloride through a ring-gap space in a ring-gap reactor to produce a reaction gas; the ring-gap space having a cross-sectional area and a volume; and, after the flowing, further reacting, adiabatically, the reaction gas in a second zone to produce a hot reaction gas that contains vinylchiorosilane; wherein the second zone has a cross-sectional area that is greater than the cross-sectional area of the ring-gap space; and wherein the second zone has a volume that is in a ratio to the volume of the ring-gap space of 0.15:1 to 1.5:1. The invention also provides an apparatus for carrying out the above process.

摘要翻译： 本发明涉及一种制备乙烯基氯硅烷的方法，其包括在550-700℃的温度下使氯代硅烷与氯乙烯进行热和非催化反应，通过使氯代硅烷和氯乙烯通过环 - 间隙反应器产生反应气体; 所述环间隙具有横截面积和体积; 并且在流动之后，绝热地将第二区中的反应气体进行反应，以产生含有乙烯基氯硅烷的热反应气体; 其中所述第二区域具有大于所述环形间隙的横截面面积的横截面面积; 并且其中所述第二区域具有与所述环隙空间的体积的比率为0.15:1至1.5:1的体积。 本发明还提供一种用于执行上述过程的装置。

公开(公告)号：US5843948A

公开(公告)日：1998-12-01

申请号：US994754

申请日：1997-12-19

申请人： Wolfgang Kehrbach ,  Uwe Schoen ,  Jack A. J. den Hartog ,  Jan H. van Maarseveen ,  Chris G. Kruse ,  Jochen Antel ,  Jan-Hendrik Reinders ,  Dieter Ziegler ,  Gerhard-Wilhelm Bielenberg

发明人： Wolfgang Kehrbach ,  Uwe Schoen ,  Jack A. J. den Hartog ,  Jan H. van Maarseveen ,  Chris G. Kruse ,  Jochen Antel ,  Jan-Hendrik Reinders ,  Dieter Ziegler ,  Gerhard-Wilhelm Bielenberg

IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P7/02 ,  C07D213/74 ,  C07D213/78 ,  C07D295/14 ,  C07D295/155 ,  C07D295/135 ,  C07D401/04

CPC分类号： C07D213/74 ,  C07D295/155 ,  Y02P20/55

摘要： Compounds having fibrinogen receptor-antagonistic activity, of the general formula I ##STR1## in which Z is oxygen or a methylene group, B is a phenyl or pyridyl radical, R.sup.1 is hydrogen or a group forming a biolabile ester, and their physiologically acceptable acid addition salts and physiologically acceptable salts of acids of formula I.

摘要翻译： 具有纤维蛋白原受体拮抗活性的化合物，其中Z为氧或亚甲基的通式I ，B为苯基或吡啶基，R 1为氢或形成不可生物酯的基团及其生理学上可接受的酸 式I的酸的加成盐和生理上可接受的盐。

公开(公告)号：US08925334B2

公开(公告)日：2015-01-06

申请号：US13129870

申请日：2009-11-09

申请人： Heiko Zimmermann ,  Uwe Schoen ,  Guenter R. Fuhr ,  Dirk Leuthold ,  Marianne Belke

发明人： Heiko Zimmermann ,  Uwe Schoen ,  Guenter R. Fuhr ,  Dirk Leuthold ,  Marianne Belke

IPC分类号： F25D13/06 ,  F17C3/10 ,  F25D25/00 ,  F25D11/00 ,  A01N1/02 ,  G01N1/42 ,  G01N35/00

CPC分类号： A01N1/0252 ,  F25B2700/04 ,  F25D3/102 ,  F25D3/11 ,  F25D29/001 ,  F25D2600/02 ,  F25D2700/12 ,  F25D2700/16 ,  G01N1/42 ,  G01N2035/00435

摘要： The invention relates to a cryogenic storage device and to a method for operating a cryogenic storage device, particularly for cryogenic storage of biological samples, comprising a sample carrying device that is set up to accommodate samples, a cryogenic container that is set up to accommodate the sample carrying device, a container cooling device with which the cryogenic container can be cooled, an intermediate storage container that is set up for intermediate storage of the sample carrying device, a transport device with which the sample carrying device can be moved between the cryogenic container and the intermediate storage container and a sensor device with which at least one operating parameter of the cryogenic storage device can be registered. The transport device is set up to be activated in dependence on an output signal from the sensor device upon registering a predetermined operating condition of the cryogenic storage device, so that the sample carrying device is moved from the cryogenic container to the intermediate storage container. Additionally or alternatively, an intermediate storage cooling device that is set up for cooling the intermediate storage container can be activated in dependence on an output signal of the sensor device.

摘要翻译： 本发明涉及一种低温存储装置和一种用于操作低温存储装置的方法，特别是用于生物样品的低温储存的方法，包括设置用于容纳样品的样品携带装置，设置为容纳 样品运送装置，用于冷冻低温容器的容器冷却装置，设置用于样品运送装置的中间储存的中间储存容器，运送装置，使样品运送装置能够在低温容器 以及可以登记低温储存装置的至少一个操作参数的中间储存容器和传感器装置。 传送装置被设置为在登记低温存储装置的预定操作条件时依赖于来自传感器装置的输出信号被激活，使得样品携带装置从低温容器移动到中间储存容器。 另外或替代地，可以根据传感器装置的输出信号激活设置用于冷却中间存储容器的中间存储冷却装置。