利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.032 秒)

    Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof
    2.
    发明授权
    Topical formulation including diclofenac, or a pharmaceutically acceptable salt thereof 有权
    包括双氯芬酸或其药学上可接受的盐的局部制剂

    公开(公告)号：US07795309B2

    公开(公告)日：2010-09-14

    申请号：US12281561

    申请日：2007-03-06

    申请人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    发明人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    IPC分类号： A61K31/195

    CPC分类号： A61K9/0014 ,  A61K31/196 ,  A61K45/06 ,  A61K2300/00

    摘要： There is described a topical formulation. The topical formulation comprises: (i) diclofenac or a pharmaceutically acceptable salt thereof, (ii) a first compound, and (iii) a second compound. The first compound and second compound are different, and each is selected from the group consisting essentially of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate. It has been discovered that certain combination of compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of diclofenac or a pharmaceutically acceptable salt thereof. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation.

    摘要翻译： 描述了一种局部制剂。 局部制剂包括：（i）双氯芬酸或其药学上可接受的盐，（ii）第一化合物和（iii）第二化合物。 第一化合物和第二化合物是不同的，并且各自选自基本上由N-月桂酰肌氨酸，辛基硫酸钠，月桂酸甲酯，肉豆蔻酸异丙酯，油酸，油酸甘油酯和月桂基磺基乙酸钠组成的组。 已经发现，化合物的某些组合是优异的渗透增强剂，因此，可以掺入局部制剂以促进双氯芬酸或其药学上可接受的盐的给药。 渗透增加的增加也可能导致制剂中皮肤刺激物的总浓度降低。

    Topical formulation
    7.
    发明授权
    Topical formulation 有权
    专题表述

    公开(公告)号：US08343962B2

    公开(公告)日：2013-01-01

    申请号：US12848792

    申请日：2010-08-02

    申请人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    发明人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    IPC分类号： A61K31/19 ,  A61K31/195 ,  A61K31/40 ,  A61K31/444 ,  A61K31/5415

    CPC分类号： A61K47/20 ,  A61K9/2886 ,  A61K31/19 ,  A61K31/195 ,  A61K31/40 ,  A61K31/444 ,  A61K31/5415 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16

    摘要： It has been discovered that certain combinations compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) at least one active agent; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.

    摘要翻译： 已经发现，某些组合化合物是优异的渗透增强剂，因此，可以掺入局部制剂以促进活性剂的给药。 渗透增加的增加也可能导致制剂中皮肤刺激物的总浓度降低。 本文描述了局部制剂，其包含（i）至少一种活性剂; （ii）第一化合物和（iii）第二化合物，其中第一化合物和第二化合物不同，并且各自选自N-月桂酰肌氨酸，辛基硫酸钠，月桂酸甲酯，肉豆蔻酸异丙酯，油酸 酸，油酸甘油酯和月桂基磺基乙酸钠。

    TOPICAL FORMULATION
    8.
    发明申请
    TOPICAL FORMULATION 有权
    主题配方

    公开(公告)号：US20110028460A1

    公开(公告)日：2011-02-03

    申请号：US12848792

    申请日：2010-08-02

    申请人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    发明人： Edward T. Kisak ,  John M. Newsam ,  Dominic King-Smith ,  Pankaj Karande ,  Samir Mitragotri

    IPC分类号： A61K31/19 ,  A61K31/195 ,  A61K31/40 ,  A61K31/444 ,  A61K31/5415 ,  A61P29/00

    CPC分类号： A61K47/20 ,  A61K9/2886 ,  A61K31/19 ,  A61K31/195 ,  A61K31/40 ,  A61K31/444 ,  A61K31/5415 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16

    摘要： It has been discovered that certain combinations compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) at least one active agent; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.

    摘要翻译： 已经发现，某些组合化合物是优异的渗透增强剂，因此可以掺入局部制剂以促进活性剂的给药。 渗透增加的增加也可能导致制剂中皮肤刺激物的总浓度降低。 本文描述了局部制剂，其包含（i）至少一种活性剂; （ii）第一化合物和（iii）第二化合物，其中第一化合物和第二化合物不同，并且各自选自N-月桂酰肌氨酸，辛基硫酸钠，月桂酸甲酯，肉豆蔻酸异丙酯，油酸 酸，油酸甘油酯和月桂基磺基乙酸钠。