公开(公告)号：US20060111336A1

公开(公告)日：2006-05-25

申请号：US10537476

申请日：2003-11-26

申请人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

发明人： Joseph Duffy ,  Robert Mathvink ,  Ann Weber ,  Jinyou Xu

IPC分类号： A61K31/426 ,  A61K31/401 ,  A61K31/397 ,  C07D277/56

CPC分类号： C07D295/185 ,  A61K31/40 ,  C07D207/10 ,  C07D207/16 ,  C07D277/04

摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20050222140A1

公开(公告)日：2005-10-06

申请号：US10481352

申请日：2003-11-03

申请人： Vincent Colandrea ,  Scott Edmondson ,  Robert Mathvink ,  Anthony Mastracchio ,  Ann Weber ,  Jinyou Xu

发明人： Vincent Colandrea ,  Scott Edmondson ,  Robert Mathvink ,  Anthony Mastracchio ,  Ann Weber ,  Jinyou Xu

IPC分类号： A61K31/395 ,  A61K31/40 ,  A61K31/445 ,  A61K31/54 ,  A61P3/10 ,  C07D205/04 ,  C07D207/10 ,  C07D211/30 ,  C07D211/38 ,  C07D213/64 ,  C07D279/12 ,  C07D295/18 ,  C07D295/185 ,  C07D401/10 ,  C07D401/12 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D205/04 ,  C07D207/10 ,  C07D211/38 ,  C07D213/64 ,  C07D295/185 ,  C07D401/10 ,  C07D401/12 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D471/04 ,  C07D487/04

摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20060270679A1

公开(公告)日：2006-11-30

申请号：US11500252

申请日：2006-08-07

申请人： Scott Edmondson ,  Michael Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma Parmee ,  Ann Weber ,  Jinyou Xu

发明人： Scott Edmondson ,  Michael Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma Parmee ,  Ann Weber ,  Jinyou Xu

IPC分类号： A61K31/498 ,  C07D487/04

CPC分类号： A61K31/4985 ,  A61K31/498 ,  A61K38/28 ,  A61K45/06 ,  C07D487/04 ,  Y10S514/866 ,  A61K2300/00

摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

公开(公告)号：US08653059B2

公开(公告)日：2014-02-18

申请号：US12672100

申请日：2008-08-18

申请人： Tesfaye Biftu ,  Danqing Feng ,  Ann E. Weber ,  Jason M. Cox ,  Xiaoxia Qian ,  Jinyou Xu

发明人： Tesfaye Biftu ,  Danqing Feng ,  Ann E. Weber ,  Jason M. Cox ,  Xiaoxia Qian ,  Jinyou Xu

IPC分类号： A61K31/33

CPC分类号： C07D487/04 ,  C07D471/04 ,  C07D487/14 ,  C07D498/04 ,  C07D513/04

摘要： The present invention is directed to substituted six-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as obesity and diabetes, particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶的抑制剂的结构式（I）的取代的六元杂环化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如肥胖和糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US07687492B2

公开(公告)日：2010-03-30

申请号：US11587605

申请日：2005-04-29

申请人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott D. Edmondson

发明人： Jinyou Xu ,  Lan Wei ,  Anthony Mastracchio ,  Scott D. Edmondson

IPC分类号： A61K31/4245 ,  A61K31/397 ,  A61K31/4525 ,  A61K31/454 ,  A61P3/10 ,  C07D271/07 ,  C07D413/08

CPC分类号： C07D271/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新的1,2,4-恶二唑衍生物，其可用于治疗或预防其中二肽基肽酶 - 涉及IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US08440672B2

公开(公告)日：2013-05-14

申请号：US12377136

申请日：2007-08-29

申请人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Ellen K. Vande Bunte ,  Lin Chu ,  Debra Ondeyka ,  Ihor Kopka ,  Bing Li ,  Hyun Ok ,  Minal J. Patel ,  Jinyou Xu ,  Rosemary Sisco

发明人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Ellen K. Vande Bunte ,  Lin Chu ,  Debra Ondeyka ,  Ihor Kopka ,  Bing Li ,  Hyun Ok ,  Minal J. Patel ,  Jinyou Xu ,  Rosemary Sisco

IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/444 ,  C07D401/14 ,  C07D401/04

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D417/14

摘要： The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

摘要翻译： 本发明提供了作为5-脂氧合酶活化蛋白抑制剂的式I化合物。 式（I）的化合物可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护剂。

公开(公告)号：US07309714B2

公开(公告)日：2007-12-18

申请号：US10537476

申请日：2003-11-26

申请人： Joseph L. Duffy ,  Robert J. Mathvink ,  Ann E. Weber ,  Jinyou Xu

发明人： Joseph L. Duffy ,  Robert J. Mathvink ,  Ann E. Weber ,  Jinyou Xu

IPC分类号： A61K31/426 ,  A61K31/40 ,  A61K31/397 ,  A61K31/4453 ,  C07D277/04 ,  C07D207/08 ,  C07D205/04

CPC分类号： C07D295/185 ,  A61K31/40 ,  C07D207/10 ,  C07D207/16 ,  C07D277/04

摘要： The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US20060281727A1

公开(公告)日：2006-12-14

申请号：US10573108

申请日：2004-10-29

申请人： Wallace Ashton ,  Hong Dong ,  Jinyou Xu

发明人： Wallace Ashton ,  Hong Dong ,  Jinyou Xu

IPC分类号： A61K31/513 ,  A61K31/498 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/397 ,  C07D487/02 ,  C07D403/02

CPC分类号： C07D207/10 ,  A61K38/00 ,  C07D205/04

摘要： The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-RV抑制剂”）的抑制剂的稠合苯丙氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US06699871B2

公开(公告)日：2004-03-02

申请号：US10189603

申请日：2002-07-05

申请人： Scott D. Edmondson ,  Michael H. Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma R. Parmee ,  Ann E. Weber ,  Jinyou Xu

发明人： Scott D. Edmondson ,  Michael H. Fisher ,  Dooseop Kim ,  Malcolm Maccoss ,  Emma R. Parmee ,  Ann E. Weber ,  Jinyou Xu

IPC分类号： C07D48704

CPC分类号： A61K31/4985 ,  A61K31/498 ,  A61K38/28 ,  A61K45/06 ,  C07D487/04 ,  Y10S514/866 ,  A61K2300/00

摘要： The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的化合物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

公开(公告)号：US09029377B2

公开(公告)日：2015-05-12

申请号：US13382469

申请日：2010-06-28

申请人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

发明人： Anthony Ogawa ,  Feroze Ujjainwalla ,  Lin Chu ,  Bing Li ,  Lan Wei ,  Jinyou Xu ,  Hyun Ok ,  Aaron Lackner ,  Ihor Kopka

IPC分类号： A61K31/50 ,  A61K31/4965 ,  A61K31/505 ,  A61K31/44 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/42 ,  C07D487/00 ,  C07D401/00 ,  C07D403/00 ,  C07D231/02 ,  C07D271/00 ,  C07D261/02 ,  C07D249/08 ,  G01C23/00 ,  G08G5/00

CPC分类号： G01C23/00 ,  G08G5/0056

摘要： Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other PAF-mediated disorders, including inflammatory, cardiovascular, and immune disorders.

摘要翻译： 作为血小板活化因子（PAF）受体拮抗剂的环己基磺酰胺化合物。 所述化合物可用于例如治疗动脉粥样硬化或其它PAF介导的病症，包括炎性，心血管和免疫疾病。