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1.
公开(公告)号:US20110098301A1
公开(公告)日:2011-04-28
申请号:US11886132
申请日:2006-03-09
申请人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
发明人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu
IPC分类号: A61K31/5377 , C07D401/12 , A61K31/506 , C07D401/14 , C07D239/48 , C07D403/12 , C07D413/14 , A61K31/496 , A61P35/00
CPC分类号: C07D239/48 , C07D401/12 , C07D401/14
摘要: Pyrimidine derivatives of formula pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are disclosed and claimed.
摘要翻译: 公开并要求保护含有这些化合物的配方药物组合物的嘧啶衍生物和使用这些化合物治疗过度增殖性疾病如癌症的方法。
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2.
公开(公告)号:US07678804B2
公开(公告)日:2010-03-16
申请号:US11078681
申请日:2005-03-10
申请人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号: C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
CPC分类号: C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译: 式(I)的嘧啶衍生物,其中J和Y表示芳族或杂芳族环; R2,G,G'和G“表示取代基,R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物,以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号:US07582646B2
公开(公告)日:2009-09-01
申请号:US11078681
申请日:2005-03-10
申请人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianqing Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号: C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/14 , A61K31/505 , A61K31/506 , A61P35/00
摘要: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
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4.
公开(公告)号:US20100075967A1
公开(公告)日:2010-03-25
申请号:US12550010
申请日:2009-08-28
申请人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
发明人: Julie A. Dixon , Dhanapalan Nagarathnam , Lei Zhang , Chunguang Wang , Lin Yi , Yuanwei Chen , Jianging Chen , Brian R. Bear , Michael Brands , Alexander Hillisch , Donald Bierer , Ming Wang , Wenlang Fu , Martin F. Hentemann , Ann-Marie Bullion , Manoj Patel
IPC分类号: A61K31/5377 , C07D401/12 , C07D239/02 , C07D413/12 , A61K31/506 , A61P35/00
CPC分类号: C07D401/12 , C04B35/632 , C07D239/47 , C07D239/48 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D453/02
摘要: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G′, and G″ represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
摘要翻译: 式(I)的嘧啶衍生物,其中J和Y代表芳族或杂芳族环; R2,G,G'和G“表示取代基,R2a表示H或卤素; L表示连接基团; 并且M代表CH或N.还公开和要求保护含有这些化合物的药物组合物,以及使用这些化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号:US20090258888A1
公开(公告)日:2009-10-15
申请号:US11918016
申请日:2006-04-07
申请人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
发明人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear , Aaron Schmitt , Eric Mull , David Miller , Jin Zhao
IPC分类号: A61K31/506 , C07D239/46 , A61P35/00
CPC分类号: C07D401/12
摘要: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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公开(公告)号:US20090286785A1
公开(公告)日:2009-11-19
申请号:US11887976
申请日:2006-04-07
申请人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
发明人: Dhanapalan Nagarathnam , Yuanwei Chen , Wenlang Fu , Donald Bierer , Ming Wang , Michael Brands , Yamin Wang , Brian R. Bear
IPC分类号: A61K31/5377 , C07D413/14 , A61P35/00 , C07D401/14 , A61K31/506
CPC分类号: C07D401/12 , C07D401/14 , C07D405/14
摘要: This invention relates to novel compounds (I) and processes for their preparation, methods of treating diseases, particularly cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly cancer.
摘要翻译: 本发明涉及新化合物(I)及其制备方法,治疗疾病,特别是癌症的方法,包括给药所述化合物,以及制备用于治疗或预防病症,特别是癌症的药物组合物的方法。
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公开(公告)号:US08524767B2
公开(公告)日:2013-09-03
申请号:US12704605
申请日:2010-02-12
申请人: Mark T. Miller , Sara S. Hadida Ruah , Brian R. Bear , Peter D. J. Grootenhuis , Jason McCartney
发明人: Mark T. Miller , Sara S. Hadida Ruah , Brian R. Bear , Peter D. J. Grootenhuis , Jason McCartney
IPC分类号: A61K31/36 , C07D317/46
CPC分类号: C07D498/04 , A61K31/167 , A61K31/357 , A61K31/381 , A61K31/40 , A61K31/437 , A61K31/443 , A61K31/519 , A61K31/538 , A61K45/06 , C07C235/16 , C07D207/48 , C07D317/54 , C07D317/60 , C07D317/68 , C07D405/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译: 本发明的化合物及其药学上可接受的组合物可用作ATP结合盒(“ABC”)转运蛋白或其片段的调节剂,包括囊性纤维化跨膜电导调节剂(“CFTR”)。 本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。
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