利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

10 条记录 (耗时 0.045 秒)

    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    1.
    发明授权
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US07670785B2

    公开(公告)日：2010-03-02

    申请号：US11811442

    申请日：2007-06-07

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael A. Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael A. Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N33/554 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    2.
    发明授权
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US07244573B2

    公开(公告)日：2007-07-17

    申请号：US10308279

    申请日：2002-12-03

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： G01N33/53 ,  G01N33/564 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis
    4.
    发明申请
    Polynucleotides and polypeptides associated with the development of rheumatoid arthritis 有权
    与类风湿性关节炎发展相关的多核苷酸和多肽

    公开(公告)号：US20090004184A1

    公开(公告)日：2009-01-01

    申请号：US11811442

    申请日：2007-06-07

    申请人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    发明人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  A61K39/395 ,  A61P19/02

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

    摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

    TGF-.beta. induced gene
    5.
    发明授权
    TGF-.beta. induced gene 失效
    TGF-β诱导的基因

    公开(公告)号：US5444164A

    公开(公告)日：1995-08-22

    申请号：US878960

    申请日：1992-05-04

    申请人： Anthony F. Purchio ,  John E. Skonier ,  Michael G. Neubauer

    发明人： Anthony F. Purchio ,  John E. Skonier ,  Michael G. Neubauer

    IPC分类号： C12N15/09 ,  C07K14/00 ,  C07K14/47 ,  C07K14/495 ,  C07K14/52 ,  C07K14/71 ,  C07K16/00 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91 ,  C07H15/12

    CPC分类号： C07K14/71

    摘要： A new TGF-.beta. induced gene and protein is described. Treatment of TGF-.beta. growth arrested cells induces the production of a novel gene which encodes a 683 amino acid protein, designated BIG-H3, that contains four homologous repeat regions and which may represent a cell surface recognition molecule. This gene and protein is induced in mammalian cells, and specifically human cells, upon treatment with TGF-.beta., and is shown to inhibit the growth of tumor cells.

    摘要翻译： 描述了一种新的TGF-β诱导的基因和蛋白质。 TGF-β生长停滞细胞的治疗诱导产生一种新的基因，其编码含有四个同源重复区并且可以代表细胞表面识别分子的称为BIG-H3的683氨基酸蛋白。 在用TGF-β处理后，该哺乳动物细胞，特别是人细胞中诱导该基因和蛋白质，并且显示其抑制肿瘤细胞的生长。

    KCNQ2 potassium channels
    6.
    发明授权
    KCNQ2 potassium channels 有权
    KCNQ2钾通道

    公开(公告)号：US07482431B2

    公开(公告)日：2009-01-27

    申请号：US11707363

    申请日：2007-02-16

    申请人： Michael A. Blanar ,  Paul C. Levesque ,  Wayne A. Little ,  Michael G. Neubauer ,  Wen-Pin Yang

    发明人： Michael A. Blanar ,  Paul C. Levesque ,  Wayne A. Little ,  Michael G. Neubauer ,  Wen-Pin Yang

    IPC分类号： C07K14/705

    CPC分类号： C07K14/705 ,  A61K48/00

    摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

    摘要翻译： 本发明涉及定义钾通道的KCNQ蛋白。 特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。 本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷， 运动神经元疾病，癫痫，中风等。

    KCNQ potassium channels and methods of modulating same
    7.
    发明授权
    KCNQ potassium channels and methods of modulating same 有权
    KCNQ钾通道及其调节方法

    公开(公告)号：US07262289B2

    公开(公告)日：2007-08-28

    申请号：US10131685

    申请日：2002-04-24

    申请人： Michael A. Blanar ,  Wen-Pin Yang ,  Paul C. Levesque ,  Michael G. Neubauer ,  Wayne A. Little

    发明人： Michael A. Blanar ,  Wen-Pin Yang ,  Paul C. Levesque ,  Michael G. Neubauer ,  Wayne A. Little

    IPC分类号： C12N14/705

    CPC分类号： C07K14/705 ,  A61K48/00

    摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

    摘要翻译： 本发明涉及定义钾通道的KCNQ蛋白。 特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。 本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷， 运动神经元疾病，癫痫，中风等。

    DNA encoding rodent KCNQ2 potassium channel
    8.
    发明授权
    DNA encoding rodent KCNQ2 potassium channel 有权
    编码啮齿动物KCNQ2钾通道的DNA

    公开(公告)号：US07041496B2

    公开(公告)日：2006-05-09

    申请号：US10128870

    申请日：2002-04-24

    申请人： Michael A. Blanar ,  Steven Dworetzky ,  Wen-Pin Yang ,  Paul C. Levesque ,  Valentin K. Gribkoff ,  Michael G. Neubauer ,  Wayne A. Little

    发明人： Michael A. Blanar ,  Steven Dworetzky ,  Wen-Pin Yang ,  Paul C. Levesque ,  Valentin K. Gribkoff ,  Michael G. Neubauer ,  Wayne A. Little

    IPC分类号： C12N15/11 ,  C12N5/10 ,  C12N15/63

    CPC分类号： C07K14/705 ,  A61K48/00

    摘要： The present invention relates to KCNQ proteins defining potassium channels. In particular, the invention concerns the human KCNQ2, human KCNQ3, murine KCNQ2, and rat KCNQ2 proteins reported herein. KCNQ2 and KCNQ3 proteins are nervous system-selective and may be involved in neurotransmission and neuroprotection. The KCNQ2 and KCNQ3 of the present invention can be used to assay for modulators of the proteins, which would be useful in treatment of such disorders as ataxia, myokymia, seizures, Alzheimer's disease, Parkinson's disease, age-associated memory loss, learning deficiencies, motor neuron diseases, epilepsy, stroke, and the like.

    摘要翻译： 本发明涉及定义钾通道的KCNQ蛋白。 特别地，本发明涉及本文报道的人KCNQ2，人类KCNQ3，鼠KCNQ2和大鼠KCNQ2蛋白。 KCNQ2和KCNQ3蛋白是神经系统选择性的，可能参与神经传递和神经保护。 本发明的KCNQ2和KCNQ3可用于测定蛋白质的调节剂，其可用于治疗诸如共济失调，myokymia，癫痫发作，阿尔茨海默氏病，帕金森病，年龄相关记忆丧失，学习缺陷， 运动神经元疾病，癫痫，中风等。