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    Low-Salt Soy Sauce
    1.
    发明申请
    Low-Salt Soy Sauce 有权
    低盐酱油

    公开(公告)号：US20080057174A1

    公开(公告)日：2008-03-06

    申请号：US11575834

    申请日：2005-08-05

    申请人： Jun Yamakoshi ,  Kohsuke Matsumoto ,  Makoto Saito ,  Hitomi Aota ,  Takeharu Nakahara ,  Satoshi Fukuda ,  Tetsuya Oguma ,  Norikazu Fujii

    发明人： Jun Yamakoshi ,  Kohsuke Matsumoto ,  Makoto Saito ,  Hitomi Aota ,  Takeharu Nakahara ,  Satoshi Fukuda ,  Tetsuya Oguma ,  Norikazu Fujii

    IPC分类号： A23L1/238

    CPC分类号： A23L33/185 ,  A23L27/50 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2250/5488

    摘要： A low common salt soy sauce, which has good flavor, significantly suppresses elevation of blood pressure, prevents cardiac hypertrophy, and is also available as special nutritious food, is obtained. 1.0% to 10.0% by weight of potassium chloride and 0.1% to 5.0% by weight of γ-aminobutyric acid are added to a reduced common salt soy sauce, so as to obtain a low common salt soy sauce of issue. Otherwise, a KCl-containing low common salt soy sauce is obtained by: (1) a common production method of soy sauce, in which a mixed solution consisting of KCl and common salt is used as mother water; (2) a method of subjecting a soy sauce obtained using saline solution as mother water to electrodialysis, a membrane treatment, or the like, so as to eliminate common salt from the above soy sauce, and then adding KCl thereto; or other methods. Thereafter, γ-aminobutyric acid is added to the above KCl-containing low common salt soy sauce, so as to obtain a low common salt soy sauce comprising 0% to 10% by weight of common salt, 1.0% to 10.0% by weight of potassium chloride, and 0.1% to 5.0% by weight of γ-aminobutyric acid.

    摘要翻译： 具有良好风味的低盐酱油显着抑制血压升高，预防心脏肥大，也可作为特殊营养食品使用。 将1.0％至10.0％重量的氯化钾和0.1％至5.0％的γ-氨基丁酸加入到还原的普通盐酱油中，以获得低常见的酱油。 另外，含有KCl的低盐酱油是通过以下方法获得的：（1）将由KCl和普通盐组成的混合溶液用作母水的酱油的常规生产方法; （2）使用盐水溶液得到的酱油作为母水进行电渗析，膜处理等，以从上述酱油中除去常见的盐，然后加入KCl; 或其他方法。 然后，向上述含有KCl的低盐酱油中加入γ-氨基丁酸，得到含有0〜10重量％的普通盐，1.0〜10.0重量％ 氯化钾和0.1重量％〜5.0重量％的γ-氨基丁酸。

    Low-salt soy sauce
    2.
    发明授权
    Low-salt soy sauce 有权
    低盐酱油

    公开(公告)号：US07718209B2

    公开(公告)日：2010-05-18

    申请号：US11575834

    申请日：2005-08-05

    申请人： Jun Yamakoshi ,  Kohsuke Matsumoto ,  Makoto Saito ,  Hitomi Aota ,  Takeharu Nakahara ,  Satoshi Fukuda ,  Tetsuya Oguma ,  Norikazu Fujii

    发明人： Jun Yamakoshi ,  Kohsuke Matsumoto ,  Makoto Saito ,  Hitomi Aota ,  Takeharu Nakahara ,  Satoshi Fukuda ,  Tetsuya Oguma ,  Norikazu Fujii

    IPC分类号： A23L1/40

    CPC分类号： A23L33/185 ,  A23L27/50 ,  A23V2002/00 ,  A23V2200/326 ,  A23V2250/5488

    摘要： A low common salt soy sauce, which has good flavor, significantly suppresses elevation of blood pressure, prevents cardiac hypertrophy, and is also available as special nutritious food, is obtained. 1.0% to 10.0% by weight of potassium chloride and 0.1% to 5.0% by weight of γ-aminobutyric acid are added to a reduced common salt soy sauce, so as to obtain a low common salt soy sauce of issue. Otherwise, a KCl-containing low common slat soy sauce is obtained by: (1) a common production method of soy sauce, in which a mixed solution consisting of KCl and common salt is used as mother water; (2) a method of subjecting a soy sauce obtained using saline solution as mother water to electrodialysis, a membrane treatment, or the like, so as to eliminate common salt from the above soy sauce, and then adding KCl thereto; or other methods. Thereafter, γ-aminobutyric acid is added to the above KCl-containing low common salt soy sauce, so as to obtain a low common salt soy sauce comprising 0% to 10% by weight of common salt, 1.0% to 10.0% by weight of potassium chloride, and 0.1% to 5.0% by weight of γ-aminobutyric acid.

    摘要翻译： 具有良好风味的低盐酱油显着抑制血压升高，预防心脏肥大，也可作为特殊营养食品使用。 将1.0％至10.0％重量的氯化钾和0.1％至5.0％重量的γ-氨基丁酸加入到还原的普通盐酱油中，以获得低常见的酱油。 另外，含有KCl的低普通板条酱油是通过以下方法获得的：（1）将由KCl和普通盐组成的混合溶液用作母水的酱油的常规生产方法; （2）使用盐水溶液得到的酱油作为母水进行电渗析，膜处理等，以从上述酱油中除去常见的盐，然后加入KCl; 或其他方法。 然后，向上述含有KCl的低盐酱油中加入γ-氨基丁酸，得到含有0〜10重量％的普通盐，1.0〜10.0重量％ 氯化钾和0.1〜5.0重量％的γ-氨基丁酸。

    Cyclic oligosaccharide, and an agent containing the same for preventing or treating retroviral diseases
    3.
    发明授权
    Cyclic oligosaccharide, and an agent containing the same for preventing or treating retroviral diseases 失效
    环状低聚糖和含有该寡糖的药剂用于预防或治疗逆转录病毒疾病

    公开(公告)号：US6060597A

    公开(公告)日：2000-05-09

    申请号：US127126

    申请日：1998-07-30

    申请人： Koichiro Tobe ,  Makoto Saito ,  Shoichi Tokutake ,  Satoshi Kitao ,  Tetsuya Oguma ,  Kahee Fujita

    发明人： Koichiro Tobe ,  Makoto Saito ,  Shoichi Tokutake ,  Satoshi Kitao ,  Tetsuya Oguma ,  Kahee Fujita

    IPC分类号： A61K31/715 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  C08B37/00 ,  C08B37/16 ,  C08B30/18

    CPC分类号： C08B37/0009 ,  C08B37/0012

    摘要： A cyclic oligosaccharide or salts thereof comprising glucoses bound cyclically via .alpha.-1,6-linkages and having at least one S-oxo acid group bound, and ana gent for preventing or treating retroviral diseases which comprises said cyclic oligosaccharide or salts thereof as an active ingredient. The novel sulfated cyclic isomaltoligosaccharide inhibits infection of host cells with various retroviruses such as AIDS virus etc. so effectively that it has a significant preventive and therapeutic effect on diseases caused by retroviruses. Accordingly, said oligosaccharide can be utilized as an agent for preventing or treating retroviral diseases in pharmaceutical industry.

    摘要翻译： 一种环状寡糖或其盐，其包含通过α-1,6键循环结合并具有至少一个结合的S-氧代酸基团的葡萄糖，以及用于预防或治疗包含所述环状寡糖或其盐作为活性的逆转录病毒疾病的方法 成分。 新型硫酸化环状异麦芽寡糖抑制宿主细胞与各种逆转录病毒如艾滋病病毒等的感染，从而对逆转录病毒引起的疾病具有显着的预防和治疗作用。 因此，所述寡糖可以用作制药工业中用于预防或治疗逆转录病毒病的药剂。

    Enzyme for producing novel cyclooisomaltooligosaccharides
    5.
    发明授权
    Enzyme for producing novel cyclooisomaltooligosaccharides 失效
    用于生产新型环型低聚半乳糖的酶

    公开(公告)号：US5453369A

    公开(公告)日：1995-09-26

    申请号：US284318

    申请日：1994-08-02

    申请人： Tetsuya Oguma ,  Tatsuo Horiuchi ,  Koichiro Tobe

    发明人： Tetsuya Oguma ,  Tatsuo Horiuchi ,  Koichiro Tobe

    IPC分类号： C08B37/02 ,  C12N9/44 ,  C12P19/18 ,  C12N9/10 ,  C12N9/24

    CPC分类号： C12N9/2451 ,  C08B37/0021 ,  C12P19/18

    摘要： The present invention relates to a novel cycloisomaltooligosaccharide selected from the group consisting of novel cycloisomaltoheptaose having a cyclic structure composed of 7 glucose residues in .alpha.-1,6 linkage, novel cycloisomaltooctaose having a cyclic structure composed of 8 glucose residues in .alpha.-1,6 linkage and novel cycloisomaltononaose having a cyclic structure composed of 9 glucose residues in .alpha.-1,6 linkage, novel cycloisomaltooligosaccharide synthase forming said oligosaccharides from dextran, and a process for producing said oligosaccharides by use of said enzyme or a microorganism capable of producing said enzyme.

    摘要翻译： 本发明涉及一种选自下组的新型环状半缩水甘露寡糖，其由具有由α-1,6键连接的7个葡萄糖残基组成的环状结构的新型环异麦芽糖糖，具有由α-1,6中的8个葡萄糖残基组成的环状结构的新型环状体细菌 连接和具有由α-1,6键连接的9个葡萄糖残基组成的环状结构的新型环状马耳骨霉素，以及由右旋糖酐形成所述寡糖的新型环状二缩水甘露糖合成酶，以及通过使用所述酶或能够产生所述酶的微生物来生产所述寡糖的方法 。

    Purified cyclodextrinase
    6.
    发明授权
    Purified cyclodextrinase 失效
    纯化CYCLODEXTRINASE

    公开(公告)号：US5110734A

    公开(公告)日：1992-05-05

    申请号：US533856

    申请日：1990-06-06

    申请人： Tetsuya Oguma ,  Mamoru Kikuchi ,  Kiyoshi Mizusawa ,  Shoichi Tokutake ,  Nobuyuki Yamaji

    发明人： Tetsuya Oguma ,  Mamoru Kikuchi ,  Kiyoshi Mizusawa ,  Shoichi Tokutake ,  Nobuyuki Yamaji

    IPC分类号： C12N9/24 ,  C12P19/14

    CPC分类号： C12Y302/01054 ,  C12N9/2402 ,  C12P19/14

    摘要： The present invention relates to a novel cyclodextrinase having the specific physicochemical characteristics relating to action, substrate specificities, optimum pH, stable pH, inhibition, activation and molecular, weight. This novel enzyme can be produced by culturing a specified microorganism belonging to the genus Bacillus. The invention also provides a process for preparing maltooligosaccharides by acting the present enzyme to cyclodextrins.

    摘要翻译： 本发明涉及具有与作用，底物特异性，最佳pH，稳定pH，抑制，活化和分子重量有关的特定物理化学特性的新型环糊精酶。 这种新型酶可以通过培养属于芽孢杆菌属的特定微生物来产生。 本发明还提供了通过将本发明酶作用于环糊精来制备麦芽低聚糖的方法。

    Cycloisomaltooligosaccharides
    7.
    发明授权
    Cycloisomaltooligosaccharides 失效
    环状异麦芽低聚糖

    公开(公告)号：US5364936A

    公开(公告)日：1994-11-15

    申请号：US174596

    申请日：1993-12-28

    申请人： Tetsuya Oguma ,  Tatsuo Horiuchi ,  Koichiro Tobe

    发明人： Tetsuya Oguma ,  Tatsuo Horiuchi ,  Koichiro Tobe

    IPC分类号： C08B37/02 ,  C12N9/44 ,  C12P19/18 ,  C08B37/16

    CPC分类号： C12N9/2451 ,  C08B37/0021 ,  C12P19/18

    摘要： The present invention relates to a novel cycloisomaltooligosaccharide selected from the group consisting of novel cycloisomaltoheptaose having a cyclic structure composed of 7 glucose residues in .alpha.-1,6 linkage, novel cycloisomaltooctaose having a cyclic structure composed of 8 glucose residues in .alpha.-1,6 linkage and novel cycloisomaltononaose having a cyclic structure composed of 9 glucose residues in .alpha.-1,6 linkage, novel cycloisomaltooligosaccharide synthase forming said oligosaccharides from dextran, and a process for producing said oligosaccharides by use of said enzyme or a microorganism capable of producing said enzyme.

    摘要翻译： 本发明涉及一种选自下组的新型环状半缩水甘露寡糖，其由具有由α-1,6键连接的7个葡萄糖残基组成的环状结构的新型环异麦芽糖糖，具有由α-1,6中的8个葡萄糖残基组成的环状结构的新型环状体细菌 连接和具有由α-1,6键连接的9个葡萄糖残基组成的环状结构的新型环状马耳骨霉素，以及由右旋糖酐形成所述寡糖的新型环状二缩水甘露糖合成酶，以及通过使用所述酶或能够产生所述酶的微生物来生产所述寡糖的方法 。

    Protein having glutaminase activity and gene encoding the same
    8.
    发明授权
    Protein having glutaminase activity and gene encoding the same 有权
    具有谷氨酰胺酶活性的蛋白质和编码相同的基因

    公开(公告)号：US06881565B2

    公开(公告)日：2005-04-19

    申请号：US10123116

    申请日：2002-04-17

    申请人： Kotaro Ito ,  Tetsuya Oguma ,  Yasuji Koyama

    发明人： Kotaro Ito ,  Tetsuya Oguma ,  Yasuji Koyama

    IPC分类号： C12N9/80 ,  C12N9/78 ,  C12N15/55

    CPC分类号： C12N9/80

    摘要： There are disclosed a protein having an amino acid sequence shown in SEQ ID NO:2, or a protein having a glutaminase activity in which one or more amino acids is/are deleted from, substituted by, inserted to or added to the amino acid sequence of the above protein; a gene containing DNA encoding the above protein or a gene which hybridizes with the a complementary sequence of DNA of the above gene under a stringent condition and encodes a protein having a glutaminase activity; a recombinant DNA containing the above gene; a transformant or a transductant containing the above recombinant DNA; and a process for producing glutaminase which comprises culturing the above transformant or the above transductant and collecting glutaminase from a culture medium.

    摘要翻译： 公开了具有SEQ ID NO：2所示的氨基酸序列的蛋白质或具有谷氨酰胺酶活性的蛋白质，其中一个或多个氨基酸被从氨基酸序列中删除，插入或添加到氨基酸序列中 的上述蛋白质; 含有编码上述蛋白质的DNA的基因或与上述基因的DNA的互补序列在严格条件下杂交的基因，并编码具有谷氨酰胺酶活性的蛋白质; 含有上述基因的重组DNA; 含有上述重组DNA的转化体或转导体; 以及生产谷氨酰胺酶的方法，其包括培养上述转化体或上述转导体并从培养基中收集谷氨酰胺酶。