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    Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative
    2.
    发明授权
    Inhibitor of kainic acid neurotoxicity and pyridothiazine derivative 失效
    红藻氨酸神经毒性抑制剂和吡啶并噻嗪衍生物

    公开(公告)号：US6133258A

    公开(公告)日：2000-10-17

    申请号：US68534

    申请日：1998-05-13

    申请人： Jun-ichi Shishikura ,  Hiroshi Inami ,  Tomoyuki Yasunaga ,  Masaaki Hirano ,  Shuichi Sakamoto ,  Kazushige Ohno ,  Masamichi Okada ,  Shin-ichi Tsukamoto

    发明人： Jun-ichi Shishikura ,  Hiroshi Inami ,  Tomoyuki Yasunaga ,  Masaaki Hirano ,  Shuichi Sakamoto ,  Kazushige Ohno ,  Masamichi Okada ,  Shin-ichi Tsukamoto

    IPC分类号： A61K31/5415 ,  A61K31/542 ,  C07D513/04

    CPC分类号： A61K31/5415

    摘要： Neuroprotective agents based on inhibition of kainic acid neurotoxicity and compounds useful as neuroprotective agents based on inhibition of kainic acid neurotoxicity. An inhibitors of kainic acid neurotoxicity, comprising as an active ingredient a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof, and a pyridothiazine derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein symbols in the formula have the following respective meanings: the ring A: a pyridine ring; ##STR2## R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 may be the same or different and each represent a hydrogen atom or a lower alkyl, cycloalkyl, alkenyl, aryl, carboxyl or lower alkoxycarbonyl group which may have substituent(s), or are not present, with the proviso that R.sup.2 and R.sup.3 may together form a nitrogen-containing heterocyclic group which may have nitrogen atoms as another hetero atom, may be fused with a benzene ring and may have a lower alkyl group as a substituent.

    摘要翻译： PCT No.PCT / JP96 / 03339 Sec。 371日期1998年5月13日 102（e）日期1998年5月13日PCT 1996年11月14日PCT PCT。 出版物WO97 / 17970 日期1997年5月22日基于抑制红藻氨酸神经毒性的神经保护剂和基于抑制红藻氨酸神经毒性作用的神经保护剂的化合物。 作为活性成分的红藻氨酸神经毒性抑制剂，含有下述通式（I）所示的吡哆噻嗪衍生物或其药学上可接受的盐，以及下述通式（I）表示的吡哒嗪衍生物或其药学上可接受的盐 其中式中的符号具有以下各自的含义：环A：吡啶环; R 1，R 2，R 3，R 4和R 5可以相同或不同，各自表示氢原子或可以具有取代基或不存在的低级烷基，环烷基，烯基，芳基，羧基或低级烷氧基羰基， 条件是R2和R3可以一起形成可以具有氮原子作为另一个杂原子的含氮杂环基，可以与苯环稠合并且可以具有低级烷基作为取代基。

    ACYLAMINOPIPERIDINE COMPOUND
    3.
    发明申请
    ACYLAMINOPIPERIDINE COMPOUND 失效
    ACYLAMINOPIPERIDINE化合物

    公开(公告)号：US20090131666A1

    公开(公告)日：2009-05-21

    申请号：US12294145

    申请日：2007-03-23

    申请人： Toru Kontani ,  Noriyuki Kawano ,  Naoyuki Masuda ,  Koji Kato ,  Hiroshi Nagata ,  Hiroshi Inami ,  Tadashi Terasaka ,  Kazuhiro Yokoyama ,  Takahiro Miyazaki

    发明人： Toru Kontani ,  Noriyuki Kawano ,  Naoyuki Masuda ,  Koji Kato ,  Hiroshi Nagata ,  Hiroshi Inami ,  Tadashi Terasaka ,  Kazuhiro Yokoyama ,  Takahiro Miyazaki

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D487/04

    摘要： [Problem] To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. [Means for Resolution] An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C1-C6 alkylene, R1: phenyl which may be substituted, etc., R2: —H or C1-C6 alkyl, R3: —H, C1-C6 alkyl or C3-C8 cycloalkyl, R4: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].

    摘要翻译： [问题]提供具有优异活性以调节CCR4或TARC和/或MDC功能的化合物，并可用于预防和/或治疗各种炎性疾病，过敏性疾病，自身免疫性疾病等。 [解决方法]由式（I）表示的酰氨基哌啶化合物或其药学上可接受的盐。 [式中的符号表示以下含义： A：单键或C1-C6亚烷基，R1：可被取代的苯基等，R2：-H或C1-C6烷基，R3：-H，C1-C6烷基或C3-C8环烷基，R4：吡咯烷 -2-基，其可以被取代等，D：苯环或吡唑环]。

    Substrate holding device and manufacturing method therefor
    7.
    发明授权
    Substrate holding device and manufacturing method therefor 失效
    基板保持装置及其制造方法

    公开(公告)号：US5685363A

    公开(公告)日：1997-11-11

    申请号：US568767

    申请日：1995-12-07

    申请人： Koichi Orihira ,  Yasunori Ando ,  Hiroshi Inami

    发明人： Koichi Orihira ,  Yasunori Ando ,  Hiroshi Inami

    IPC分类号： G02F1/13 ,  C23C14/50 ,  G02F1/1333 ,  H01J37/317 ,  H01L21/00 ,  H01L21/265 ,  H01L21/302 ,  H01L21/3065 ,  H01L21/683 ,  F28F23/00

    CPC分类号： H01L21/67103 ,  Y10T29/4935

    摘要： A substrate holding device of the invention includes a base cooled with a heat absorbing fluid, a flexible sheet being extended on a surface of the base for forming a sealed portion between the sheet and the base, a heat absorbing fluid with which the sealed portion is filled, a sheet-like rubber elastic material being disposed on the sheet, and a substrate retainer for pressing fringes of a substrate, placed on the rubber elastic material, against the base. Metal elastic members may be distributed almost uniformly in the sealed portion, in place of or together with, the rubber elastic material.

    摘要翻译： 本发明的基板保持装置包括用吸热流体冷却的基底，柔性片在基底的表面上延伸，以形成片与基部之间的密封部分，密封部分为 填充在片材上的片状橡胶弹性材料和用于将放置在橡胶弹性材料上的基底的条纹压靠在基底上的基片保持器。 金属弹性构件可以几乎均匀地分布在密封部分中，代替橡胶弹性材料或与橡胶弹性材料一起。