公开(公告)号：US20090171036A1

公开(公告)日：2009-07-02

申请号：US12282554

申请日：2007-03-14

申请人： Junichi Ide ,  Koichiro Toyota

发明人： Junichi Ide ,  Koichiro Toyota

IPC分类号： C08L67/04

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  C08G63/823 ,  Y10S585/906 ,  C08L67/04

摘要： [Problems]To provide a material for producing a bioabsorbable material in which it is easy to remove a metal zinc catalyst from a bioabsorbable polymer such as a polymer of lactide or a polymer of lactide and caprolactone and it is easy to recycle the removed powdery metal zinc catalyst, and to provide a bioabsorbable material produced from the material for producing a bioabsorbable material.[Means for Solving Problems]A material for producing a bioabsorbable material including a three-dimensionally shaped metal zinc polymerization catalyst and a bioabsorbable polymer such as a polymer of lactide or a polymer of lactide and caprolactone; and a process for producing a material for producing a bioabsorbable material, characterized in that in the process for producing a bioabsorbable polymer by polymerization, a three-dimensionally shaped metal zinc catalyst is used as a polymerization catalyst.

摘要翻译： [问题]提供一种生物可吸收材料的制造方法，其中容易从生物可吸收性聚合物如丙交酯聚合物或丙交酯和己内酯的聚合物中除去金属锌催化剂，并且容易地将去除的粉末状金属 锌催化剂，并且提供由用于生产生物可吸收材料的材料制备的生物可吸收材料。 解决问题的手段一种生物可吸收材料的制造方法，其特征在于，包括三维形状的金属锌聚合催化剂和生物可吸收性聚合物如丙交酯或丙交酯和己内酯的聚合物; 以及生产生物可吸收材料的材料的方法，其特征在于，在通过聚合制备生物可吸收聚合物的方法中，使用三维形状的金属锌催化剂作为聚合催化剂。

公开(公告)号：US08158729B2

公开(公告)日：2012-04-17

申请号：US12282554

申请日：2007-03-14

申请人： Junichi Ide ,  Koichiro Toyota

发明人： Junichi Ide ,  Koichiro Toyota

IPC分类号： C08G63/91

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  C08G63/823 ,  Y10S585/906 ,  C08L67/04

摘要： [PROBLEMS]To provide a material for producing a bioabsorbable material in which it is easy to remove a metal zinc catalyst from a bioabsorbable polymer such as a polymer of lactide or a polymer of lactide and caprolactone and it is easy to recycle the removed powdery metal zinc catalyst, and to provide a bioabsorbable material produced from the material for producing a bioabsorbable material.[MEANS FOR SOLVING PROBLEMS]A material for producing a bioabsorbable material including a three-dimensionally shaped metal zinc polymerization catalyst and a bioabsorbable polymer such as a polymer of lactide or a polymer of lactide and caprolactone; and a process for producing a material for producing a bioabsorbable material, characterized in that in the process for producing a bioabsorbable polymer by polymerization, a three-dimensionally shaped metal zinc catalyst is used as a polymerization catalyst.

摘要翻译： 本发明提供一种生物可吸收材料的制造方法，其中容易从生物可吸收性聚合物如丙交酯聚合物或丙交酯和己内酯的聚合物中除去金属锌催化剂，并且容易地将除去的粉末状金属 锌催化剂，并且提供由用于生产生物可吸收材料的材料制备的生物可吸收材料。 解决问题的手段一种生物体可吸收材料的制造方法，其特征在于，包括三维形状的金属锌聚合催化剂和生物可吸收性聚合物如丙交酯或丙交酯和己内酯的聚合物; 以及生产生物可吸收材料的材料的制造方法，其特征在于，在通过聚合制造生物可吸收性聚合物的方法中，使用三维形状的金属锌催化剂作为聚合催化剂。

公开(公告)号：US08366639B2

公开(公告)日：2013-02-05

申请号：US12593204

申请日：2008-02-08

申请人： Koichiro Toyota ,  Hideki Munekuni ,  Hisashi Miyata

发明人： Koichiro Toyota ,  Hideki Munekuni ,  Hisashi Miyata

IPC分类号： A61B5/117 ,  A61B5/103 ,  A61B5/00

CPC分类号： A61B5/228 ,  A61B5/038 ,  A61B5/411

摘要： A balloon including: a pressure-receiving portion formed of an elastic material and forming an enclosed space; and a tubular portion formed integrally therewith. The balloon is configured to detect the air pressure in the pressure-receiving portion due to communication with a pressure detector through an opening end of the tubular portion. A transverse cross-section of the pressure-receiving portion orthogonal to the axial direction of the tubular portion has a flattened outer circumferential shape with an oblateness f=(A−B)/A, where A represents the length of a major axis of the outer circumferential shape and B represents the length of a minor axis thereof, being set to a range of 0.1≦f≦0.7 at a position at which the length A is at a maximum. The air pressure can be changed significantly and stably, and the precision of the pressure measurement can be increased.

摘要翻译： 一种气球，包括：由弹性材料形成并形成封闭空间的压力接收部分; 和与其一体形成的管状部分。 气囊被配置为通过管状部分的开口端与压力检测器连通来检测压力接收部分中的空气压力。 与管状部的轴向正交的受压部的横截面为扁平状，f =（A-B）/ A，其中A表示长度方向的长度， 外周形状，B表示其短轴的长度，在长度A为最大的位置处，设定为0.1＆lt; 1lE; f＆nlE; 0.7的范围。 能够显着稳定地变更气压，能够提高压力测定的精度。

公开(公告)号：US06682916B2

公开(公告)日：2004-01-27

申请号：US10069105

申请日：2002-02-26

申请人： Naoaki Taoka ,  Hironobu Maeda ,  Kazumi Okuro ,  Koichiro Toyota ,  Yoshihiko Yasohara

发明人： Naoaki Taoka ,  Hironobu Maeda ,  Kazumi Okuro ,  Koichiro Toyota ,  Yoshihiko Yasohara

IPC分类号： F12P718

CPC分类号： C12P41/002 ,  C07B2200/07 ,  C07C45/29 ,  C07C49/255 ,  C12P7/04 ,  C12P7/18 ,  C12P7/26 ,  C07C49/175

摘要： A process for efficiently preparing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an intermediate for medicines. The process comprises treating an inexpensive racemic chloropropanediol derivative with a nitroxyl compound and an oxidizing agent to convert it into a chlorohydroxyacetone derivative and then stereospecifically reducing the carbonyl group of the chlorohydroxyacetone derivative by the action of either a carbonyl-reducing enzyme having the ability to stereospecifically reduce the chlorohydroxyacetone derivative or an optically treated culture of a microorganism having the ability to yield the carbonyl-reducing enzyme. Thus, an optically active chloropropanediol derivative is prepared.

摘要翻译： 一种有效制备光学活性氯丙醇二醇衍生物，特别是（S）-1-苄氧基-3-氯-2-丙醇的方法，该方法具有高的光学纯度并且可用作药物的中间体。 该方法包括用硝酰化合物和氧化剂处理廉价的外消旋氯丙二醇衍生物，将其转化成氯羟丙酮衍生物，然后通过具有立体特异性的羰基还原酶的作用立即特异性还原氯羟基丙酮衍生物的羰基 减少氯代羟基丙酮衍生物或具有产生羰基还原酶能力的微生物的光学处理培养物。 因此，制备光学活性氯丙二醇衍生物。

公开(公告)号：US20130190656A1

公开(公告)日：2013-07-25

申请号：US13877403

申请日：2011-09-20

申请人： Koichiro Toyota

发明人： Koichiro Toyota

IPC分类号： A61B5/00

CPC分类号： A61B5/4205 ,  A61B5/224 ,  A61B5/682 ,  G01L19/149

摘要： A device for measuring oral cavity pressure includes the following: a pressure measuring probe 1 having a configuration in which a balloon 4 made of an elastic material is supported by a balloon base 5; a communicating member having an inner bore that communicates with the inside of the balloon via the balloon base to transmit the air pressure in the balloon; and a pressure detecting unit 8 that is connected to the rear end of the communicating member and detects the transmitted air pressure. The balloon includes a pressure receiving portion 4a that forms a cavity and a balloon tubular portion 4b that communicates with the inside of the pressure receiving portion, and the balloon is joined to the front end portion of the balloon base with the balloon tubular portion. The balloon base has a rib 5c that protrudes outward along the outer circumferential direction of the front end portion on the balloon side. The device for measuring oral cavity pressure uses the pressure measuring probe including a flat balloon and allows the balloon to be inserted into the oral cavity in an appropriate state, and thus stably can ensure good measurement accuracy.

摘要翻译： 用于测量口腔压力的装置包括：压力测量探针1，其具有由弹性材料制成的球囊4由球囊基座5支撑的构造; 连通构件，其具有经由所述球囊基部与所述球囊的内部连通的内孔，以传递气囊中的空气压力; 以及压力检测单元8，其连接到连通构件的后端并检测传送的空气压力。 气囊包括形成空腔的压力接收部分4a和与压力接收部分内部连通的气囊管状部分4b，并且球囊与气囊管状部分接合到球囊基座的前端部分。 球囊基部具有沿气囊侧的前端部的外周方向向外突出的肋5c。 用于测量口腔压力的装置使用包括平坦球囊的压力测量探针，并且允许气囊以适当的状态插入口腔，从而稳定地确保良好的测量精度。

公开(公告)号：US20100222706A1

公开(公告)日：2010-09-02

申请号：US11991043

申请日：2006-07-27

申请人： Hideyasu Miyahara ,  Koichiro Toyota

发明人： Hideyasu Miyahara ,  Koichiro Toyota

IPC分类号： A61B5/103

CPC分类号： A61B5/038 ,  A61B5/22 ,  A61B5/682 ,  A63B21/0085 ,  A63B23/032

摘要： A probe for measuring oral pressure according to the present invention includes: a balloon 1; a hollow tube 3 that has a first opening portion 3b and a second opening portion 3c and is connected to the balloon so that the first opening potion 3b communicates with an inside of the balloon 1; and a port member 20 with a valve 13 connected to the hollow tube 3 so as to block the second opening portion 3c. The probe for measuring oral pressure according to the present invention preferably further includes a hard ring 8 mounted on a portion between an inflated portion and an attaching portion of the balloon 1. The valve 13 may be a disk-shaped valve with an insertion hole 13a, for example.

摘要翻译： 根据本发明的用于测量口腔压力的探针包括：气囊1; 中空管3，其具有第一开口部3b和第二开口部3c，并且与气囊连接，使得第一开口部3b与气囊1的内部连通; 以及端口构件20，其具有连接到中空管3的阀13，以便阻挡第二开口部分3c。 根据本发明的用于测量口腔压力的探针优选还包括安装在气囊1的充气部分和附接部分之间的部分上的硬环8.阀13可以是具有插入孔13a的盘形阀 ， 例如。

公开(公告)号：US20100121224A1

公开(公告)日：2010-05-13

申请号：US12593204

申请日：2008-02-08

申请人： Koichiro Toyota ,  Hideki Munekuni ,  Hisashi Miyata

发明人： Koichiro Toyota ,  Hideki Munekuni ,  Hisashi Miyata

IPC分类号： A61B5/103 ,  B29D22/00

CPC分类号： A61B5/228 ,  A61B5/038 ,  A61B5/411

摘要： A balloon for measuring a pressure related to the oral cavity including a pressure-receiving portion 20 that is formed of an elastic material and that internally forms an enclosed space and a tubular portion 21 that is formed integrally with the pressure-receiving portion, the balloon being configured to detect the air pressure in the interior of the pressure-receiving portion by communicating the interior of the pressure-receiving portion with a pressure detector through an opening end of the tubular portion. A transverse cross-section of the pressure-receiving portion orthogonal to the axial direction of the tubular portion has a flattened outer circumferential shape with an oblateness f=(A−B)/A, where A represents the length of a major axis of the outer circumferential shape and B represents the length of a minor axis thereof being set to a range of 0.1≦f≦0.7 at a position at which the length A of the major axis is at a maximum. The air pressure can be changed significantly and stably, and the precision of the measurement of a pressure related to the oral cavity can be increased.

摘要翻译： 用于测量与口腔有关的压力的气囊，包括由弹性材料形成并在内部形成封闭空间的压力接收部分20和与压力接收部分整体形成的管状部分21 被配置成通过管状部分的开口端将压力接收部分的内部与压力检测器连通来检测压力接收部分内部的空气压力。 与管状部的轴向正交的受压部的横截面为扁平状，f =（A-B）/ A，其中A表示长度方向的长度， 外圆周形状，B表示其长轴的长度在长轴的长度A为最大的位置处设定为0.1＆lt; 1lE; f＆nlE; 0.7的范围。 能够显着稳定地变更气压，能够提高与口腔相关的压力的测量精度。

公开(公告)号：US20090198182A1

公开(公告)日：2009-08-06

申请号：US11630670

申请日：2005-06-29

申请人： Ichiro Fujishima ,  Koichiro Toyota ,  Toshinobu Sajiki

发明人： Ichiro Fujishima ,  Koichiro Toyota ,  Toshinobu Sajiki

IPC分类号： A61M25/095 ,  A61M1/00

CPC分类号： A61L29/14 ,  A61J15/00 ,  A61J15/0026 ,  A61J15/0069 ,  A61J15/0088 ,  A61J2205/20 ,  A61M25/00 ,  A61M25/01 ,  A61M2025/0008

摘要： The present invention provides a member (2) for catheter position verification having permeability for body fluid, characterized by including a color change indicator (2A) capable of color changing upon contact with body fluid, the color change indicator (2A) when used fitted to a medical catheter (3) to be incorporated in the body or a connection member connected to the medical catheter (3). Further, there is provided a medical catheter comprising this member for catheter position verification. The use of the above medical catheter including the member for catheter position verification realizes simpler, more reliable and safer execution of treatment and examination.

摘要翻译： 本发明提供一种用于导管位置检验的构件（2），其具有体液渗透性，其特征在于，包括能够与体液接触时能够变色的变色指示器（2A），所述变色指示器（2A） 医疗导管（3），其被结合到主体中，或连接到医疗导管（3）的连接构件。 此外，提供了一种医疗导管，其包括用于导管位置验证的该构件。 包括用于导管位置检查的构件的上述医疗导管的使用实现了更简单，更可靠和更安全地执行治疗和检查。