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公开(公告)号:US20090075968A1
公开(公告)日:2009-03-19
申请号:US12159502
申请日:2006-12-27
申请人: Junichi Sakaki , Masashi Kishida , Naoko Matsuura , Ichiro Umemura , Eiji Kawahara , Ken Yamada , Kazuhide Konishi , Yuki Iwaki , Hidetomo Imase , Takahiro Miyake
发明人: Junichi Sakaki , Masashi Kishida , Naoko Matsuura , Ichiro Umemura , Eiji Kawahara , Ken Yamada , Kazuhide Konishi , Yuki Iwaki , Hidetomo Imase , Takahiro Miyake
IPC分类号: A61K31/4439 , C07D401/12 , C07D213/26 , C07D401/04 , A61K31/506 , A61K31/55 , A61P3/00 , A61P9/00 , A61K31/397 , A61K31/5377 , A61K31/444 , C07D413/14 , C07D401/14
CPC分类号: C07D401/12 , C07D213/74 , C07D401/14 , C07D405/14 , C07D409/14
摘要: The present invention relates to a compound of formula or a pharmaceutically acceptable salt thereof, wherein the variables are as defined.
摘要翻译: 本发明涉及式的化合物或其药学上可接受的盐,其中变量如上所定义。
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公开(公告)号:US08232403B2
公开(公告)日:2012-07-31
申请号:US12300208
申请日:2007-05-08
申请人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号: A61K31/47 , C07D215/46
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14
摘要: The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
摘要翻译: 本发明涉及新的式(I)化合物或其药物组合物,其全部变量在本文中定义。 本发明还涉及本文中的化合物用于治疗或延缓进展到涉及CETP的疾病的公开。
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公开(公告)号:US20090227580A1
公开(公告)日:2009-09-10
申请号:US12300208
申请日:2007-05-08
申请人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号: A61K31/5377 , A61K31/506 , A61K31/4709 , C07D413/14 , C07D401/12
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14
摘要: The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
摘要翻译: 本发明涉及新的式(I)化合物或其药物组合物,其全部变量在本文中定义。 本发明还涉及本文中的化合物用于治疗或延缓进展到涉及CETP的疾病的公开。
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公开(公告)号:US08410275B2
公开(公告)日:2013-04-02
申请号:US13473649
申请日:2012-05-17
申请人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
发明人: Masashi Kishida , Naoko Matsuura , Hidetomo Imase , Yuki Iwaki , Ichiro Umemura , Osamu Ohmori , Eiji Kawahara
IPC分类号: C07D215/38
CPC分类号: C07D471/04 , C07D401/12 , C07D401/14
摘要: The present invention relates to novel compounds of formula (I) or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.
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公开(公告)号:US20090131436A1
公开(公告)日:2009-05-21
申请号:US11574019
申请日:2005-08-26
申请人: Patricia Imbach , Eiji Kawahara , Kazuhide Konishi , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Johannes Roesel , Naoki Teno , Ichiro Umemura
发明人: Patricia Imbach , Eiji Kawahara , Kazuhide Konishi , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Johannes Roesel , Naoki Teno , Ichiro Umemura
IPC分类号: A61K31/5377 , C07D413/14 , A61K31/506 , C07D403/12 , A61P35/00
CPC分类号: C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D409/14 , C07D413/12
摘要: Novel pyrimidine derivatives of formula (I) to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 式(I)的新型嘧啶衍生物用于其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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6.2,4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS 审中-公开
标题翻译: 2,4-PYRIMININEDIAMINES有用的治疗神经疾病,炎症和免疫系统疾病公开(公告)号:US20110098280A1
公开(公告)日:2011-04-28
申请号:US12984519
申请日:2011-01-04
申请人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
发明人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
IPC分类号: A61K31/505 , C07D239/48 , C07D405/12 , A61K31/506 , C07D403/12 , C07D413/12 , A61K31/5377 , C07D401/12 , C07D417/14 , A61K31/541 , C07D401/14 , C07D498/04 , A61K31/5383 , C07D413/14 , A61K31/55 , A61P35/00
CPC分类号: C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 式I的新型嘧啶衍生物用于其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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7.2, 4-Pyrimidinediamines Useful In The Treatment Of Neoplastic Diseases, Inflammatory And Immune System Disorders 有权
标题翻译: 2,4-嘧啶二胺可用于治疗新生儿疾病,炎症和免疫系统疾病公开(公告)号:US20080132504A1
公开(公告)日:2008-06-05
申请号:US10568367
申请日:2004-08-13
申请人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
发明人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
IPC分类号: A61K31/506 , A61K31/497 , A61K31/535 , A61P29/00 , A61P35/00 , A61P37/00 , C07D239/48 , C07D403/12 , C07D413/12
CPC分类号: C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them
摘要翻译: 式I的新型嘧啶衍生物用于其制备方法,它们作为药物的用途以及包含它们的药物组合物
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公开(公告)号:US20110201606A1
公开(公告)日:2011-08-18
申请号:US13095760
申请日:2011-04-27
申请人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号: A61K31/5383 , C07D239/48 , C07D401/12 , C07D413/12 , C07D403/14 , C07D265/36 , A61K31/506 , A61K31/505 , A61K31/5377 , A61K31/497 , A61P35/00
CPC分类号: C07D401/12 , C07D239/48 , C07D401/14
摘要: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them
摘要翻译: 式I的新型嘧啶衍生物用于其制备方法,它们作为药物的用途以及包含它们的药物组合物
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9.2,4-di (phenylamino) pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders 有权
标题翻译: 2,4-二(苯基氨基)嘧啶可用于治疗肿瘤性疾病,炎症和免疫系统疾病公开(公告)号:US07964592B2
公开(公告)日:2011-06-21
申请号:US10549250
申请日:2004-03-12
申请人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
发明人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura
IPC分类号: C07D239/48 , A61K31/506
CPC分类号: C07D401/12 , C07D239/48 , C07D401/14
摘要: Novel pyrimidine derivatives of formula I to process for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 用于制备式I的新型嘧啶衍生物,其用作药物和包含它们的药物组合物。
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10.2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders 有权
标题翻译: 2,4-嘧啶二胺可用于治疗肿瘤性疾病,炎症和免疫系统疾病公开(公告)号:US07893074B2
公开(公告)日:2011-02-22
申请号:US10568367
申请日:2004-08-13
申请人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
发明人: Carlos Garcia-Echeverria , Takanori Kanazawa , Eiji Kawahara , Keiichi Masuya , Naoko Matsuura , Takahiro Miyake , Osamu Ohmori , Ichiro Umemura , Ruo Steensma , Greg Chopiuk , Jiqing Jiang , Yongqin Wan , Qiang Ding , Qiong Zhang , Nathanael Schiander Gray , Donald Karanewsky
IPC分类号: C07D239/48 , A61K31/506
CPC分类号: C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要: Novel pyrimidine derivatives of formula I to processes for their production, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
摘要翻译: 式I的新型嘧啶衍生物用于其制备方法,它们作为药物的用途以及包含它们的药物组合物。
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