Remedies for diabetes
    1.
    发明授权
    Remedies for diabetes 失效
    糖尿病补救

    公开(公告)号:US06489331B1

    公开(公告)日:2002-12-03

    申请号:US09719570

    申请日:2001-04-09

    IPC分类号: A61K3152

    摘要: A medicament for the therapeutic treatment of diabetes which comprises as an active ingredient a compound represented by the general formula (I): wherein R1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R2 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, R3 represents a hydrogen atom, a lower alkyl group or a substituted or unsubstituted aralkyl group, X1 and X2 independently represent a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and the symbol “n” represents an integer of from 0 to 3, or a physiologically acceptable salt thereof.

    摘要翻译: 一种用于治疗糖尿病的药物,其包含作为活性成分的由通式(I)表示的化合物:其中R 1表示氢原子,低级烷基,取代或未取代的芳基或取代或未取代的芳族 杂环基,R2表示氢原子,低级烷基,取代或未取代的芳烷基,取代或未取代的芳基或取代或未取代的芳香族杂环基,R3表示氢原子,低级烷基或取代 或未取代的芳烷基,X 1和X 2独立地表示氢原子,低级烷基,取代或未取代的芳烷基或取代或未取代的芳基,符号“n”表示0〜3的整数,或 其生理上可接受的盐。

    Fused purine derivatives
    2.
    发明授权
    Fused purine derivatives 失效
    融合嘌呤衍生物

    公开(公告)号:US07005430B2

    公开(公告)日:2006-02-28

    申请号:US10149423

    申请日:2000-12-22

    CPC分类号: C07D487/14

    摘要: A condensed purine derivative represented by Formula (I): wherein X—Y-Z represents R1N—C═O or N═C—W, R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted aromatic heterocyclic group, a substituted or unsubstituted alicyclic heterocyclic group or the like, n represents an integer of from 0 to 3, V1 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted aromatic heterocyclic group, V2 represents a substituted lower alkyl group or a substituted or unsubstituted aromatic heterocyclic group, and when V1 represents a hydrogen atom, a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group, and for example, X—Y-Z represents R1aN—C═O and R2 represents a substituted lower alkyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alicyclic heterocyclic group, a halogen atom, a lower alkylthio group, —NR7R8, —CO2H, a lower alkoxycarbonyl group, —COHal, —CONR9R10 or —CHO, V2 may represent a lower alkyl group, a substituted or unsubstituted aralkyl group, or a substituted or unsubstituted aryl group; or a pharmacologically acceptable salt thereof.

    摘要翻译: 由式(I)表示的稠合嘌呤衍生物:化学式id =“CHEM-US-00001”num =“000”

    Fused pyrimidine derivatives
    3.
    发明申请
    Fused pyrimidine derivatives 审中-公开
    融合嘧啶衍生物

    公开(公告)号:US20060252780A1

    公开(公告)日:2006-11-09

    申请号:US10554254

    申请日:2004-04-23

    IPC分类号: A61K31/519 C07D487/14

    CPC分类号: C07D487/14

    摘要: A fused pyrimidine derivative is presented. The derivatie has an insulin secretion stimulating activity represented by Formula (I): {wherein R1 represents a hydrogen atom, lower alkyl, or the like; n represents an integer of 0 to 3; and X1 and X2 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like; and formula (II): represents formula (III): [wherein X—Y—Z represents R2C═CR3—NR4 (wherein R2, R3 and R4 may be the same or different and each represents a hydrogen atom, lower alkyl, or the like)]}, or a pharmaceutically acceptable salt thereof.

    摘要翻译: 提出了一种稠合的嘧啶衍生物。 衍生物具有由式(I)表示的胰岛素分泌刺激活性:其中R 1表示氢原子,低级烷基等; n表示0〜3的整数, X 1和X 2可以相同或不同,各自表示氢原子,低级烷基等; 和式(II):表示式(III):[其中XYZ表示R 2 C-CR 3 -NR 4(其中R' O 2,R 3和R 4可以相同或不同,各自表示氢原子,低级烷基等)]}, 或其药学上可接受的盐。

    Electromagnetic fuel injection valve for internal combustion engine
    10.
    发明授权
    Electromagnetic fuel injection valve for internal combustion engine 失效
    内燃机电磁燃油喷射阀

    公开(公告)号:US5161743A

    公开(公告)日:1992-11-10

    申请号:US763515

    申请日:1991-09-20

    IPC分类号: F02M51/06 F02M61/06 F02M61/08

    摘要: An electromagnetic fuel injection valve for use in an internal combustion engine includes a valve body provided with a valve seat and a valve member having an abutting part moved within the valve body by an electromagnetic actuator between a closed position where the abutting part abuts against the valve seat to interrupt supply of fuel to the engine and an open position where the abutting portion is spaced from the valve seat to permit supply of the fuel to the engine. The valve member has a metering portion which cooperates with the valve seat to define therebetween a fuel metering gap when the valve member is in the open position. The abutting part of the valve member is located downstream of the metering portion with reference to a flow direction of the fuel so that the metering portion is always immersed in the fuel when the valve member is in the closed position.

    摘要翻译: 一种用于内燃机的电磁燃料喷射阀包括一阀体,该阀体设置有阀座和阀构件,该阀体具有一抵靠部件,该抵接部件通过电磁致动器在阀体内移动, 以阻止向发动机供应燃料和打开位置,其中抵接部分与阀座间隔开以允许向发动机供应燃料。 阀构件具有计量部分,其在阀构件处于打开位置时与阀座配合以在其间限定燃料计量间隙。 阀构件的邻接部分相对于燃料的流动方向位于计量部分的下游,使得当阀构件处于关闭位置时,计量部分总是浸入燃料中。