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公开(公告)号:US5863930A
公开(公告)日:1999-01-26
申请号:US574082
申请日:1995-12-18
申请人: Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
发明人: Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Andreas Knorr , Johannes-Peter Stasch , Siegfried Zaiss
IPC分类号: A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07D213/79 , C07D401/10
CPC分类号: C07D401/10
摘要: Trisubstituted biphenyls are prepared by reacting corresponding pyridones with biphenylmethyl halogen compounds. The trisubstituted biphenyls can be employed as active compounds in medicaments.
摘要翻译: 三取代的联苯通过相应的吡啶酮与联苯基甲基卤化合物反应来制备。 三取代的联苯可用作药物中的活性化合物。
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公开(公告)号:US5407948A
公开(公告)日:1995-04-18
申请号:US239197
申请日:1994-05-06
申请人: Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人: Peter Fey , Walter Hubsch , Jurgen Dressel , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号: A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/50 , A61K31/53 , A61P9/10 , A61P9/12 , A61P43/00 , C07D213/60 , C07D213/64 , C07D213/71 , C07D213/76 , C07D213/78 , C07D213/79 , C07D401/10 , C07D401/14
CPC分类号: C07D401/14
摘要: Substituted mono- and bipyridylmethylpyridones are prepared either by reaction of pyridones with mono- or bipyridylmethylhalogen compounds or by reaction of pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substituted mono- and bipyridylmethylpyridones can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译: 取代的单 - 和二吡啶基甲基吡啶酮通过吡啶酮与单吡啶基或联吡啶甲基卤化合物的反应或通过吡啶酮取代的卤代吡啶与四唑基苯基硼酸的反应来制备。 取代的单吡啶基和联吡啶基甲基吡啶酮可用作药物中的活性化合物,特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号:US5318980A
公开(公告)日:1994-06-07
申请号:US18961
申请日:1993-02-18
申请人: Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人: Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号: A61K31/415 , A61K31/40 , A61K31/4427 , A61K31/445 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/64 , C07D233/68 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , A61K31/535 , A61K31/495
CPC分类号: C07D401/12 , C07D233/68 , C07D403/12
摘要: Sulphonylbenzyl-substituted imidazoles can be prepared by first reacting imidazolylaldehydes with sulphonylbenzyl compounds and then oxidising or reducing the aldehyde function in the customary manner.The sulphonylbenzyl-substituted imidazoles can be used as active compounds in medicaments.
摘要翻译: 磺酰基苄基取代的咪唑可以通过首先使咪唑基醛与磺酰基苄基化合物反应,然后以常规方式氧化或还原醛官能团来制备。 磺酰苄基取代的咪唑可用作药物中的活性化合物。
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公开(公告)号:US5492923A
公开(公告)日:1996-02-20
申请号:US235831
申请日:1994-04-29
申请人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号: C07D213/60 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/84 , C07D401/10
CPC分类号: C07D401/10
摘要: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译: 通过相应地取代的卤代苯与四唑基硼酸的反应来制备取代的吡啶和2-氧代-1,2-二氢吡啶。 根据本发明的取代的吡啶和2-氧代-1,2-二氢吡啶可以用作药物中的活性化合物,特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号:US5356911A
公开(公告)日:1994-10-18
申请号:US970364
申请日:1992-11-02
申请人: Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
发明人: Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Stefan Wohlfeil , Walter Hubsch , Jurgen Dressel , Peter Fey , Rudolf Hanko , Thomas Kramer , Ulrich Muller , Siegfried Zaiss
IPC分类号: A61K31/41 , A61K31/44 , A61K31/4412 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/4433 , A61K31/455 , A61P9/10 , A61P9/12 , C07D213/64 , C07D213/79 , C07D213/80 , C07D401/10 , C07D401/14 , C07D409/14
CPC分类号: C07D401/10
摘要: Substituted biphenylpyridones can be prepared by alkylating pyridones on the nitrogen. The substituted biphenylpyridones are suitable as active substances in medicaments, in particular in hypotensive and anti-atherosclerotic medicaments.
摘要翻译: 取代的联苯基吡啶酮可以通过在氮上烷基化吡啶酮来制备。 取代的联苯吡啶适合作为药物中的活性物质,特别是低血压和抗动脉粥样硬化药物。
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公开(公告)号:US5712296A
公开(公告)日:1998-01-27
申请号:US549381
申请日:1995-10-27
申请人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号: C07D213/60 , A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P27/02 , A61P43/00 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/84 , C07D401/10
CPC分类号: C07D401/10
摘要: Substituted pyridines and 2-oxo-1,2-dihydropyridines are prepared by reaction of correspondingly substituted halogenobenzenes with tetrazolylboronic acids. The substituted pyridines and 2-oxo-1,2-dihydropyridines according to the invention can be employed as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
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公开(公告)号:US5530016A
公开(公告)日:1996-06-25
申请号:US245328
申请日:1994-05-18
申请人: Thomas Kramer , Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人: Thomas Kramer , Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号: A61K31/415 , A61P9/10 , A61P9/12 , C07D207/48 , C07D257/04 , C07D403/10 , C07D403/12 , A61K31/41 , C07D257/00
CPC分类号: C07D403/10 , C07D403/12
摘要: Novel substituted 2,4-imidazolidinediones are prepared either by reaction of .alpha.-aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclization with isocyanates or by reaction of N-benzyl-substituted .alpha.-aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with .alpha.-aminocarboxylic acid derivatives and subsequent cyclization with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.
摘要翻译: 新型取代的2,4-咪唑烷二酮通过α-氨基羧酸衍生物与适当取代的联苯甲基卤化物反应,随后与异氰酸酯环化或通过N-苄基取代的α-氨基羧酸衍生物与四唑基苯基硼酸的反应或通过磺酰基 - 取代的苄基卤与α-氨基羧酸衍生物反应,随后用异氰酸酯环化。 根据本发明的化合物可以用作药物中的活性化合物,优选用于治疗动脉高血压和动脉硬化。
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公开(公告)号:US5414003A
公开(公告)日:1995-05-09
申请号:US235770
申请日:1994-04-29
申请人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
发明人: Peter Fey , Jurgen Dressel , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Ulrich Muller , Matthias Muller-Gliemann , Martin Beuck , Hilmar Bischoff , Stefan Wohlfeil , Dirk Denzer , Stanislav Kazda , Johannes-Peter Stasch , Andreas Knorr , Siegfried Zaiss
IPC分类号: A61K31/44 , A61K31/4418 , A61K31/4425 , A61K31/4427 , A61P9/10 , A61P9/12 , C07B61/00 , C07D213/64 , C07D401/04 , C07D401/14 , C07F5/02 , A61K31/50 , A61K31/53
CPC分类号: C07D401/14
摘要: Pyridinylmethyl-substituted pyridines and pyridones are prepared by reacting pyridine- or pyridone-substituted halogenopyridines with tetrazolylphenylboronic acids. The substances according to the invention can be used as active compounds in medicaments, in particular for the treatment of arterial hypertension and atherosclerosis.
摘要翻译: 吡啶基甲基取代的吡啶和吡啶酮通过吡啶或吡啶酮取代的卤代吡啶与四唑基苯基硼酸反应来制备。 根据本发明的物质可以用作药物中的活性化合物,特别是用于治疗动脉高血压和动脉粥样硬化。
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公开(公告)号:US5364942A
公开(公告)日:1994-11-15
申请号:US18964
申请日:1993-02-18
申请人: Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
发明人: Rudolf Hanko , Jurgen Dressel , Peter Fey , Walter Hubsch , Thomas Kramer , Ulrich E. Muller , Matthias Muller-Gliemann , Martin Beuck , Stanislav Kazda , Claudia Hirth-Dietrich , Andreas Knorr , Johannes-Peter Stasch , Stefan Wohlfeil , Ozkan Yalkinoglu
IPC分类号: A61K31/435 , A61K31/40 , A61K31/445 , A61K31/675 , A61P9/12 , A61P43/00 , C07D205/04 , C07D207/16 , C07D207/48 , C07D211/60 , C07D211/96 , C07D295/26 , C07D401/04 , C07D403/04 , C07D413/04 , C07D471/04 , C07F9/6561 , A61K31/415 , A61K31/44 , C07D471/06
CPC分类号: C07D295/26 , C07D207/48 , C07D211/96 , C07D471/04
摘要: Sulphonylbenzyl-substituted imidazopyridines can be prepared by reacting correspondingly substituted imidazopyridines with sulphonylbenzyl compounds. The sulphonylbenzyl-substituted imidazopyridines can be employed as active compounds in medicaments, in particular for the treatment of hypertension and atherosclerosis.
摘要翻译: 磺酰基苄基取代的咪唑并吡啶可以通过使相应取代的咪唑并吡啶与磺酰基苄基化合物反应来制备。 磺酰基苄基取代的咪唑并吡啶可用作药物中的活性化合物,特别是用于治疗高血压和动脉粥样硬化。
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公开(公告)号:US5352687A
公开(公告)日:1994-10-04
申请号:US25479
申请日:1993-03-03
申请人: Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch
发明人: Ulrich E. Muller , Matthias Muller-Gliemann , Jurgen Dressel , Peter Fey , Rudolf Hanko , Walter Hubsch , Thomas Kramer , Martin Beuck , Stanislav Kazda , Stefan Wohlfeil , Ozkan Yalkinoglu , Andreas Knorr , Johannes-Peter Stasch
IPC分类号: A61K31/415 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/10 , A61P9/12 , A61P43/00 , C07D233/68 , C07D233/90 , C07D401/12 , C07D405/12 , C07D409/06 , A61K31/535 , A61K31/47 , C07D407/10 , C07D413/10
CPC分类号: C07D401/12 , C07D233/68 , C07D405/12
摘要: Substituted phenylacetamides can be prepared by reaction of appropriately substituted phenylacetic acids with imidazoles and subsequent amidation. The substituted phenylacetic acid derivatives can be employed in medicaments for the treatment of high blood pressure and atherosclerosis.
摘要翻译: 取代的苯基乙酰胺可以通过将适当取代的苯乙酸与咪唑反应并随后进行酰胺化来制备。 取代的苯乙酸衍生物可用于治疗高血压和动脉粥样硬化的药物中。
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