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公开(公告)号:US07081561B2
公开(公告)日:2006-07-25
申请号:US10017718
申请日:2001-12-14
IPC分类号: A01K67/027 , A01K67/00 , G01N33/00 , C12N15/00
CPC分类号: C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/0312 , A01K2267/0356 , A01K2267/0362 , A01K2267/0375 , C07K14/775 , C12N2517/02 , C12N2800/30 , G01N33/6896 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要: The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
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公开(公告)号:US20060230466A1
公开(公告)日:2006-10-12
申请号:US11449216
申请日:2006-06-07
申请人: Karl Weisgraber , Robert Farese , Robert Raffai , Li-Ming Dong
发明人: Karl Weisgraber , Robert Farese , Robert Raffai , Li-Ming Dong
IPC分类号: A01K67/027 , C12N5/06
CPC分类号: C12N15/8509 , A01K67/0276 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/072 , A01K2227/105 , A01K2267/0312 , A01K2267/0356 , A01K2267/0362 , A01K2267/0375 , C07K14/775 , C12N2517/02 , C12N2800/30 , G01N33/6896 , G01N33/92 , G01N2500/10 , G01N2800/044
摘要: The invention provides gene-targeted non-human animals comprising a genetically modified apoE gene encodes a recombinant apoE polypeptide displaying domain interaction. The invention further provides cells isolated from the gene-targeted animals, which cells produce a recombinant apoE polypeptide displaying domain interaction. The invention further provides methods of identifying agents that reduce apoE4 domain interaction, and which are useful to treat apoE4-related neurological and cardiovascular disorders.
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