公开(公告)号：US20070065447A1

公开(公告)日：2007-03-22

申请号：US11413663

申请日：2006-04-28

申请人： Karl Tryggvason ,  Ida Mathiasen ,  Soren Padkaer ,  Svetlana Tarabykina ,  Sirpa Salo ,  Ariel Boutaud

发明人： Karl Tryggvason ,  Ida Mathiasen ,  Soren Padkaer ,  Svetlana Tarabykina ,  Sirpa Salo ,  Ariel Boutaud

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： A61K39/395

摘要： Novel peptides that specifically bind the γ2 chain of laminin-5 and other γ2-associated proteins; related compositions (e.g., derivatives and variants of such peptides; nucleic acids comprising sequences encoding such peptides; pharmaceutical compositions comprising either of such molecules; etc.); methods of using the same for diagnostic, prophylactic, and therapeutic purposes; and additional new and useful related compositions and methods are provided.

摘要翻译： 特异性结合层粘连蛋白-5和其他γ2相关蛋白的γ2链的新型肽; 相关组合物（例如，这种肽的衍生物和变体;包含编码这些肽的序列的核酸;包含任一种分子的药物组合物等）; 将其用于诊断，预防和治疗目的的方法; 并提供了额外的新的和有用的相关组合物和方法。

公开(公告)号：US20070014788A1

公开(公告)日：2007-01-18

申请号：US11451583

申请日：2006-06-12

申请人： Ida Mathiasen ,  Michael Bauer ,  Jorn Muller

发明人： Ida Mathiasen ,  Michael Bauer ,  Jorn Muller

IPC分类号： A61K48/00 ,  A61K39/395

CPC分类号： A61K39/395

摘要： Described herein are methods of treating or preventing various diseases and disorders using modulators of laminin-5. Exemplary diseases and disorders are inflammatory bowel disease, including ulcerative colitis and Crohn's disease, as well as polycystic kidney disease and cancers associated with one or more of the aforementioned conditions. Exemplary laminin-5 modulators include monoclonal antibodies against the laminin-5 gamma2 chain and short interfering RNA (siRNA) sequences against nucleotide sequences encoding the laminin-5 gamma2 chain. Described are also combination treatments based on the administration of a laminin-5 modulator and at least one other therapeutic agent.

摘要翻译： 本文描述的是使用层粘连蛋白-5的调节剂治疗或预防各种疾病和病症的方法。 示例性疾病和病症是炎性肠病，包括溃疡性结肠炎和克罗恩病，以及与一种或多种上述病症相关的多囊肾病和癌症。 示例性的层粘连蛋白-5调节剂包括针对层粘连蛋白-5γ2链的单克隆抗体和针对编码层粘连蛋白-5γ2链的核苷酸序列的短干扰RNA（siRNA）序列。 还描述了基于施用层粘连蛋白-5调节剂和至少一种其它治疗剂的组合治疗。