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10 条记录 (耗时 0.035 秒)

    Acylamide compounds having secretagogue or inducer activity of adiponectin
    5.
    发明授权
    Acylamide compounds having secretagogue or inducer activity of adiponectin 失效
    具有促分泌素或脂联素诱导活性的酰胺化合物

    公开(公告)号：US07732637B2

    公开(公告)日：2010-06-08

    申请号：US11835029

    申请日：2007-08-07

    申请人： Katsumi Maezono ,  Toshihiko Yoshimura ,  Nozomu Ishida ,  Naoyuki Fukuchi ,  Toshihiro Hatanaka ,  Osamu Ikehara ,  Yayoi Kawato ,  Hideyuki Tanaka

    发明人： Katsumi Maezono ,  Toshihiko Yoshimura ,  Nozomu Ishida ,  Naoyuki Fukuchi ,  Toshihiro Hatanaka ,  Osamu Ikehara ,  Yayoi Kawato ,  Hideyuki Tanaka

    IPC分类号： C07C229/06 ,  A61K31/20

    CPC分类号： C07C233/47 ,  A23L33/10 ,  C07C323/59

    摘要： The present invention provides an acylamide compound of the following formula (1), prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, therapeutic agent of metabolic syndromes, therapeutic agent of hypoadiponectinemia, therapeutic agent of hyperlipemia, preventive/therapeutic agent of diabetes, improving agent of impaired glucose tolerance, improving agent of insulin resistance, enhancing agent of insulin sensitivity, therapeutic agent of hypertension, preventive/therapeutic agent of vascular disorders, an anti-inflammatory agent, therapeutic agent of hepatic inflammation, therapeutic agent of fatty liver, therapeutic agent of hepatic fibrosis, therapeutic agent of liver cirrhosis, preventive/therapeutic agent of non-alcoholic/nonviral steatohepatitis (NASH) or non-alcoholic/nonviral fatty liver disease (NAFLD), or therapeutic agent of obesity, each of which has the above compounds as an active ingredient.

    摘要翻译： 本发明提供下式（1）的酰胺化合物，其前体药物或其药学上可接受的盐; 和脂联素诱导剂或促分泌素，代谢综合征的治疗剂，低脂联素血症的治疗剂，高脂血症的治疗剂，糖尿病的预防/治疗剂，葡萄糖耐量降低的改善剂，胰岛素抵抗的改善剂，胰岛素敏感性的增强剂，治疗 高血压药物，血管疾病的预防/治疗剂，抗炎剂，肝脏炎症治疗剂，脂肪肝治疗剂，肝纤维化治疗剂，肝硬化治疗剂，非酒精性预防/治疗剂 /非病毒性脂肪性肝炎（NASH）或非酒精性/非病毒性脂肪性肝病（NAFLD）或肥胖症治疗剂，其各自具有上述化合物作为活性成分。

    ACYLAMIDE COMPOUNDS HAVING SECRETAGOGUE OR INDUCER ACTIVITY OF ADIPONECTIN
    6.
    发明申请
    ACYLAMIDE COMPOUNDS HAVING SECRETAGOGUE OR INDUCER ACTIVITY OF ADIPONECTIN 失效
    具有ADIPONECTIN的秘密活性或诱导活性的酰亚胺化合物

    公开(公告)号：US20070282002A1

    公开(公告)日：2007-12-06

    申请号：US11835029

    申请日：2007-08-07

    申请人： Katsumi MAEZONO ,  Toshihiko Yoshimura ,  Nozomu Ishida ,  Naoyuki Fukuchi ,  Toshihiro Hatanaka ,  Osamu Ikehara ,  Yayoi Kawato ,  Hideyuki Tanaka

    发明人： Katsumi MAEZONO ,  Toshihiko Yoshimura ,  Nozomu Ishida ,  Naoyuki Fukuchi ,  Toshihiro Hatanaka ,  Osamu Ikehara ,  Yayoi Kawato ,  Hideyuki Tanaka

    IPC分类号： A61K31/198 ,  C07C235/12

    CPC分类号： C07C233/47 ,  A23L33/10 ,  C07C323/59

    摘要： The present invention provides an acylamide compound of the following formula (1), prodrugs thereof, or pharmaceutically acceptable salts thereof; and an adiponectin inducer or secretagogue, therapeutic agent of metabolic syndromes, therapeutic agent of hypoadiponectinemia, therapeutic agent of hyperlipemia, preventive/therapeutic agent of diabetes, improving agent of impaired glucose tolerance, improving agent of insulin resistance, enhancing agent of insulin sensitivity, therapeutic agent of hypertension, preventive/therapeutic agent of vascular disorders, an anti-inflammatory agent, therapeutic agent of hepatic inflammation, therapeutic agent of fatty liver, therapeutic agent of hepatic fibrosis, therapeutic agent of liver cirrhosis, preventive/therapeutic agent of non-alcoholic/nonviral steatohepatitis (NASH) or non-alcoholic/nonviral fatty liver disease (NAFLD), or therapeutic agent of obesity, each of which has the above compounds as an active ingredient.

    摘要翻译： 本发明提供下式（1）的酰胺化合物，其前体药物或其药学上可接受的盐; 和脂联素诱导剂或促分泌素，代谢综合征的治疗剂，低脂联素血症的治疗剂，高脂血症的治疗剂，糖尿病的预防/治疗剂，葡萄糖耐量降低的改善剂，胰岛素抵抗的改善剂，胰岛素敏感性的增强剂，治疗 高血压药物，血管疾病的预防/治疗剂，抗炎剂，肝脏炎症治疗剂，脂肪肝治疗剂，肝纤维化治疗剂，肝硬化治疗剂，非酒精性预防/治疗剂 /非病毒性脂肪性肝炎（NASH）或非酒精性/非病毒性脂肪性肝病（NAFLD）或肥胖症治疗剂，其各自具有上述化合物作为活性成分。

    PPAR ACTIVITY REGULATORS
    7.
    发明申请
    PPAR ACTIVITY REGULATORS 失效
    PPAR活性调节剂

    公开(公告)号：US20070276041A1

    公开(公告)日：2007-11-29

    申请号：US11753967

    申请日：2007-05-25

    申请人： Akiko Oonuki ,  Toshihiko Yoshimura ,  Katsumi Maezono ,  Yayoi Kawato ,  Hideyuki Tanaka ,  Naoyuki Fukuchi ,  Nozomu Ishida

    发明人： Akiko Oonuki ,  Toshihiko Yoshimura ,  Katsumi Maezono ,  Yayoi Kawato ,  Hideyuki Tanaka ,  Naoyuki Fukuchi ,  Nozomu Ishida

    IPC分类号： A61K31/198 ,  C07C235/04

    CPC分类号： C07C233/47 ,  C07C233/49 ,  C07C233/52 ,  C07C2601/14

    摘要： The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明的目的是提供PPAR（过氧化物酶体增殖物激活受体）活性调节剂，其可广泛用于改善胰岛素抵抗和预防/治疗各种疾病如糖尿病，代谢综合征，高脂血症，高血压，血管 疾病，炎症，肝炎，脂肪肝，肝纤维化，NASH（非酒精性脂肪性肝炎）和肥胖症。 本发明提供了包含具有特定结构的酰基酰胺化合物，其前药或其药学上可接受的盐的PPAR活性调节剂。

    PPAR activity regulators
    8.
    发明授权
    PPAR activity regulators 失效
    PPAR活性调节剂

    公开(公告)号：US07728158B2

    公开(公告)日：2010-06-01

    申请号：US11753967

    申请日：2007-05-25

    申请人： Akiko Oonuki ,  Toshihiko Yoshimura ,  Katsumi Maezono ,  Yayoi Kawato ,  Hideyuki Tanaka ,  Naoyuki Fukuchi ,  Nozomu Ishida

    发明人： Akiko Oonuki ,  Toshihiko Yoshimura ,  Katsumi Maezono ,  Yayoi Kawato ,  Hideyuki Tanaka ,  Naoyuki Fukuchi ,  Nozomu Ishida

    IPC分类号： C07C233/00 ,  A61K31/195

    CPC分类号： C07C233/47 ,  C07C233/49 ,  C07C233/52 ,  C07C2601/14

    摘要： The object of the present invention is to provide PPAR (peroxisome proliferator-activated receptor) activity regulators, which can be widely used for improving insulin resistance and preventing/treating various diseases such as diabetes, metabolic syndromes, hyperlipemia, high-blood pressure, vascular disorders, inflammation, hepatitis, fatty liver, liver fibrosis, NASH (non-alcoholic steatohepatitis) and obesity.The present invention provides PPAR activity regulators which comprise an acylamide compound having the specific structure, prodrugs thereof, or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明的目的是提供PPAR（过氧化物酶体增殖物激活受体）活性调节剂，其可广泛用于改善胰岛素抵抗和预防/治疗各种疾病如糖尿病，代谢综合征，高脂血症，高血压，血管 疾病，炎症，肝炎，脂肪肝，肝纤维化，NASH（非酒精性脂肪性肝炎）和肥胖症。 本发明提供了包含具有特定结构的酰基酰胺化合物，其前药或其药学上可接受的盐的PPAR活性调节剂。

    Apparatus for unbinding a mass of mutually sticked noodles
    10.
    发明授权
    Apparatus for unbinding a mass of mutually sticked noodles 有权
    用于解除大量相互粘贴的面条的装置

    公开(公告)号：US09163874B2

    公开(公告)日：2015-10-20

    申请号：US13230279

    申请日：2011-09-12

    申请人： Yoshiaki Nagayama ,  Nozomu Ishida

    发明人： Yoshiaki Nagayama ,  Nozomu Ishida

    IPC分类号： A23N4/04 ,  F26B1/00 ,  A21C15/00

    CPC分类号： F26B1/00 ,  A21C15/00 ,  F26B2210/06

    摘要： Within a housing, a rotating shaft extends horizontally, and curved unbinding rods are secured to the rotating shaft at diagonally opposed positions to extend in radial directions. Within the housing, an inner wall surface is arranged along a circular arc whose center is aligned with an axis of the rotating shaft and whose diameter is slightly larger than a diameter of a circle drawn by rotating tips of the unbinding rods. A portion of the inner wall surface is formed as an unbinding surface having a circular arc cross sectional shape facing the unbinding rods with a small clearance. A mass of noodles for one meal charged into the housing from the inlet is sent in the counter-clockwise direction by the unbinding rods rotated at a high speed and is hit by the unbinding rods repeatedly to perform an effective unbinding function.

    摘要翻译： 在壳体内，旋转轴水平延伸，并且弯曲的解锁杆在对角相对位置处固定到旋转轴，以沿径向方向延伸。 在壳体内，内壁表面沿着圆弧布置，其中心与旋转轴的轴线对准，并且其直径略大于通过解开杆的旋转尖端拉出的圆的直径。 内壁表面的一部分形成为具有与具有小间隙的解开杆相对的圆弧形横截面形状的非绑定表面。 从入口装入外壳的一顿饭的面条通过高速旋转的解束杆以逆时针方向被发送，并且被解绑杆重复地击打以执行有效的解除绑定功能。